ID   MTPN_XENLA              Reviewed;         118 AA.
AC   Q7T0Q1;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Myotrophin;
GN   Name=mtpn;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulates NF-kappa-B transcription factor activity. Promotes
CC       growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes
CC       cardiac muscle hypertrophy. Plays a role in the regulation of the
CC       growth of actin filaments. Inhibits the activity of the F-actin-capping
CC       protein complex (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Cytoplasm, perinuclear region {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the myotrophin family. {ECO:0000305}.
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DR   EMBL; BC056092; AAH56092.1; -; mRNA.
DR   RefSeq; NP_001079881.1; NM_001086412.1.
DR   AlphaFoldDB; Q7T0Q1; -.
DR   SMR; Q7T0Q1; -.
DR   DNASU; 379571; -.
DR   GeneID; 379571; -.
DR   KEGG; xla:379571; -.
DR   CTD; 379571; -.
DR   Xenbase; XB-GENE-1014019; mtpn.S.
DR   OrthoDB; 1435166at2759; -.
DR   Proteomes; UP000186698; Chromosome 3S.
DR   Bgee; 379571; Expressed in intestine and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   Pfam; PF12796; Ank_2; 1.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 3.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
PE   3: Inferred from homology;
KW   ANK repeat; Cytoplasm; Nucleus; Reference proteome; Repeat.
FT   CHAIN           1..118
FT                   /note="Myotrophin"
FT                   /id="PRO_0000330662"
FT   REPEAT          1..30
FT                   /note="ANK 1"
FT   REPEAT          34..65
FT                   /note="ANK 2"
FT   REPEAT          67..98
FT                   /note="ANK 3"
SQ   SEQUENCE   118 AA;  12744 MW;  BE4A7017614869CB CRC64;
     MGDKEFMWAL KNGDLDAVKE FVAGGVDVNR TLEGGRKPLH YAADCGQDEI VEFLLAKGAN
     INAADKHGIT PLLSACYEGH RKCVELFVSK GADKNVKGPD GLNAFESTDN QAIKDLLH