MTR1A_PIG
ID MTR1A_PIG Reviewed; 154 AA.
AC O02781;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=Melatonin receptor type 1A;
DE Short=Mel-1A-R;
DE Short=Mel1a receptor;
DE Flags: Fragment;
GN Name=MTNR1A;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Hypothalamus, and Pituitary;
RX PubMed=9107687; DOI=10.1007/s003359900444;
RA Messer L.A., Wang L., Tuggle C.K., Yerle M., Chardon P., Pomp D.,
RA Womack J.E., Barendse W., Crawford A.M., Notter D.R., Rothschild M.F.;
RT "Mapping of the melatonin receptor 1a (MTNR1A) gene in pigs, sheep, and
RT cattle.";
RL Mamm. Genome 8:368-370(1997).
CC -!- FUNCTION: High affinity receptor for melatonin. Likely to mediate the
CC reproductive and circadian actions of melatonin. The activity of this
CC receptor is mediated by pertussis toxin sensitive G proteins that
CC inhibit adenylate cyclase activity.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; U73326; AAC48726.1; -; Genomic_DNA.
DR AlphaFoldDB; O02781; -.
DR SMR; O02781; -.
DR BindingDB; O02781; -.
DR InParanoid; O02781; -.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0008502; F:melatonin receptor activity; IEA:InterPro.
DR GO; GO:0007623; P:circadian rhythm; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR002278; Mel_1A/1B_rcpt.
DR InterPro; IPR000025; Melatonin_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01149; MELATONIN1AR.
DR PRINTS; PR00857; MELATONINR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; G-protein coupled receptor; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN <1..>154
FT /note="Melatonin receptor type 1A"
FT /id="PRO_0000069865"
FT TOPO_DOM <1..19
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 20..40
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 41..62
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 63..83
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 84..115
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..136
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 137..149
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT NON_TER 1
FT NON_TER 154
SQ SEQUENCE 154 AA; 17900 MW; DFE85FB2C5B55C93 CRC64;
YCYICHSLKY DRWYSNRNSL CCVFLICVLT LVAIVPNLCM GTLQYDPRIY SCTFAQSVSS
AYTIAVVVFH FLVPMVIVIF RYLRIWVLVL QIRWRAKPEN NPRLKPQDFR NFVTMFVVFV
LFAICWAPLN FIGLAVASDP ASMAPRIPEW LFVA
