MTR1A_RAT
ID MTR1A_RAT Reviewed; 156 AA.
AC P49218;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 25-MAY-2022, entry version 120.
DE RecName: Full=Melatonin receptor type 1A;
DE Short=Mel-1A-R;
DE Short=Mel1a receptor;
DE Flags: Fragment;
GN Name=Mtnr1a;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Hypothalamus, and Pituitary;
RX PubMed=7946354; DOI=10.1016/0896-6273(94)90055-8;
RA Reppert S.M., Weaver D.R., Ebisawa T.;
RT "Cloning and characterization of a mammalian melatonin receptor that
RT mediates reproductive and circadian responses.";
RL Neuron 13:1177-1185(1994).
CC -!- FUNCTION: High affinity receptor for melatonin. Likely to mediate the
CC reproductive and circadian actions of melatonin. The activity of this
CC receptor is mediated by pertussis toxin sensitive G proteins that
CC inhibit adenylate cyclase activity.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: At least in the brain, more precisely in the pars
CC tuberalis and the suprachiasmatic nucleus.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; U14409; AAA57191.1; -; mRNA.
DR PIR; I62107; I62107.
DR AlphaFoldDB; P49218; -.
DR SMR; P49218; -.
DR STRING; 10116.ENSRNOP00000034328; -.
DR BindingDB; P49218; -.
DR PaxDb; P49218; -.
DR RGD; 620797; Mtnr1a.
DR eggNOG; KOG3656; Eukaryota.
DR InParanoid; P49218; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005887; C:integral component of plasma membrane; ISO:RGD.
DR GO; GO:0043025; C:neuronal cell body; IDA:RGD.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0043235; C:receptor complex; ISO:RGD.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0042562; F:hormone binding; ISO:RGD.
DR GO; GO:0008502; F:melatonin receptor activity; ISO:RGD.
DR GO; GO:0097159; F:organic cyclic compound binding; ISO:RGD.
DR GO; GO:0007193; P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; ISO:RGD.
DR GO; GO:0007568; P:aging; IEP:RGD.
DR GO; GO:0043010; P:camera-type eye development; IEP:RGD.
DR GO; GO:0007623; P:circadian rhythm; IEP:RGD.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0046676; P:negative regulation of insulin secretion; IMP:RGD.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR002278; Mel_1A/1B_rcpt.
DR InterPro; IPR000025; Melatonin_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01149; MELATONIN1AR.
DR PRINTS; PR00857; MELATONINR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN <1..>156
FT /note="Melatonin receptor type 1A"
FT /id="PRO_0000069866"
FT TRANSMEM 19..39
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 115..135
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT NON_TER 1
FT NON_TER 156
SQ SEQUENCE 156 AA; 18214 MW; 2B55EA40FBC6BAB1 CRC64;
CYICHSLKYD RIYSNKNSLC YVFLIWTLTL IAIMPNLQTG TLQYDPRIYS CTFTQSVSSA
YTIALVVFHF VVPMIIVTFC YLRIWILVLQ VRRRVKPDSK PKLKPQDFRN FVTMFVVFVL
FALCWAPLNF IGLIVASDPA TMAPRIPEWL FVASYY
