ID   MTR1A_XENLA             Reviewed;         153 AA.
AC   P51048;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Melatonin receptor type 1A X2.0;
DE            Short=Mel-1A-R X2.0;
DE            Short=Mel1a receptor X2.0;
DE   Flags: Fragment;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7576645; DOI=10.1016/0896-6273(95)90090-x;
RA   Reppert S.M., Weaver D.R., Cassone V.M., Godson C., Kolakowski L.F. Jr.;
RT   "Melatonin receptors are for the birds: molecular analysis of two receptor
RT   subtypes differentially expressed in chick brain.";
RL   Neuron 15:1003-1015(1995).
CC   -!- FUNCTION: High affinity receptor for melatonin. The activity of this
CC       receptor is mediated by pertussis toxin sensitive G proteins that
CC       inhibits adenylate cyclase activity (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U31826; AAA92500.1; -; mRNA.
DR   AlphaFoldDB; P51048; -.
DR   SMR; P51048; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008502; F:melatonin receptor activity; IEA:InterPro.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000025; Melatonin_rcpt.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00857; MELATONINR.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; G-protein coupled receptor; Membrane; Receptor;
KW   Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           <1..>153
FT                   /note="Melatonin receptor type 1A X2.0"
FT                   /id="PRO_0000069869"
FT   TOPO_DOM        <1..12
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        13..33
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        34..57
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..78
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        79..112
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        113..133
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        134..145
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        146..>153
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
FT   NON_TER         153
SQ   SEQUENCE   153 AA;  17665 MW;  ED0421422BE20F27 CRC64;
     HSSWYNRLFS NSGTICYVGL VWVLALGAIL PNLFVGSLRC DPRIFSCTFA QYVSSYYTIA
     VVIFHFFLPI GVVSYCYLRI WVLVLNIRHR VKPDRHLHHQ TWPYNIHGFI TMFVVFVLFA
     VCWGPLNIIG LTVAIYPPLG DSIPQWLFVA SYF