ID   MTR1B_CAEBR             Reviewed;         846 AA.
AC   A8XYX3;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Inactive cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1B;
DE   AltName: Full=Inactive cap1 2'O-ribose methyltransferase 1B;
DE            Short=MTr1B;
GN   ORFNames=CBG20907;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- CAUTION: Although related to the cap-specific mRNA (nucleoside-2'-O-)-
CC       methyltransferase, lacks the conserved Lys active site in position 367,
CC       which is replaced by an Asn residue, suggesting it has no
CC       methyltransferase activity. {ECO:0000305}.
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DR   EMBL; HE600928; CAP37840.2; -; Genomic_DNA.
DR   AlphaFoldDB; A8XYX3; -.
DR   SMR; A8XYX3; -.
DR   STRING; 6238.CBG20907; -.
DR   WormBase; CBG20907; CBP39443; WBGene00039811; -.
DR   eggNOG; KOG3673; Eukaryota.
DR   HOGENOM; CLU_011097_1_0_1; -.
DR   InParanoid; A8XYX3; -.
DR   OMA; RIECARV; -.
DR   OrthoDB; 1336442at2759; -.
DR   Proteomes; UP000008549; Chromosome II.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0004483; F:mRNA (nucleoside-2'-O-)-methyltransferase activity; ISS:UniProtKB.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006370; P:7-methylguanosine mRNA capping; ISS:UniProtKB.
DR   GO; GO:0097309; P:cap1 mRNA methylation; ISS:UniProtKB.
DR   GO; GO:0080009; P:mRNA methylation; ISS:UniProtKB.
DR   InterPro; IPR030376; Cap_mRNA_MeTrfase_1.
DR   InterPro; IPR000467; G_patch_dom.
DR   InterPro; IPR002877; RNA_MeTrfase_FtsJ_dom.
DR   InterPro; IPR025816; RrmJ-type_MeTrfase.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR16121:SF0; PTHR16121:SF0; 1.
DR   Pfam; PF01728; FtsJ; 1.
DR   Pfam; PF01585; G-patch; 1.
DR   SMART; SM00443; G_patch; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   PROSITE; PS50174; G_PATCH; 1.
DR   PROSITE; PS51613; SAM_MT_RRMJ; 1.
PE   4: Predicted;
KW   Reference proteome.
FT   CHAIN           1..846
FT                   /note="Inactive cap-specific mRNA (nucleoside-2'-O-)-
FT                   methyltransferase 1B"
FT                   /id="PRO_0000399799"
FT   DOMAIN          44..90
FT                   /note="G-patch"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT   DOMAIN          184..413
FT                   /note="RrmJ-type SAM-dependent 2'-O-MTase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00945"
FT   REGION          30..50
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   846 AA;  97585 MW;  CB1A2CC9989BA4E5 CRC64;
     MYVFVDRLSD SVSIPFVSKR AYRKRVNLDD DEDDFVDDPS PTEQKTKAEK KMERMGYKAG
     EGLGKNKQGI QEPIAISFRE GKAGLGHEQW DDSTENKTVE ETVIWMTNID EGIRREICDK
     LIKDDQWMVV RKEKKVIDDE TKFCSEKKLK DMLEAKNVFD SMSEKDIREA RTRANPYETI
     GSAFFLNRSA MKTANMDKIY DWILSRENTG NNSFLLKNPL QEGTTAENVD RHEDLFYFAD
     VCAGPGGFSE YMLWRKAFYN AKGFGFTLAG KDDFKLQKFT ASSAYFFETF YGTKKNGDVM
     DPENIDSLEK LISEGTDGQG VHLMMADGAF SVQGQENIQE ILSKRLYLCQ LLVSLCIVRE
     GGNFLCNLFD IFTPFSVGLI YLMRVCYDSI SLHKPHTSRP ANSERFVVCK GLRIECARVV
     KEYLKRVNRK LDELKNKNSK DDVMELMPLD VIKSDEQFMK EIIEHNEVLA HRQTVYLQKY
     KSFAKNQGQF DKDQGNLRDE CLKYWQVPNK QRPRGGDRGS HLRRGRMGNK FPEFSISMLQ
     SKIPLNIPYE EYRFVALGAA SDPQLLIGTG DAVFIYRHGH FEQIDRDYAR IPENTILLVD
     CAEEVKTDGS KIRISSDPHM IRIVDAAVLY GDNVSQLPYE ARMKAAQKFA LALKLTKKTI
     QIGWGFRAKD ITPHQVCCAQ TYSLKELDEF QSNLIELKQR GEVIVLFKEG DRQFKTQSLR
     LTRIIKQDWQ MGWSKSQQVP YVHSPLHQKE GSILEDQWKK REIHSSFWDS VILTNKDKQK
     MTEMMQHGHN AVPSTIWSWK PCMRTEYGPY KIMNHPEAFD GKPTISAIKS QIAETDLSTQ
     PSNYFY