MTR1B_CHICK
ID MTR1B_CHICK Reviewed; 289 AA.
AC P51050;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Melatonin receptor type 1B;
DE Short=Mel-1B-R;
DE Short=Mel1b receptor;
DE Flags: Fragment;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=7589552; DOI=10.1016/0014-5793(95)01129-3;
RA Liu F., Yuan H., Sugamori K.S., Hamadanizadeh A., Lee F.J.S., Pang S.F.,
RA Brown G.M., Pristupa Z.B., Niznik H.B.;
RT "Molecular and functional characterization of a partial cDNA encoding a
RT novel chicken brain melatonin receptor.";
RL FEBS Lett. 374:273-278(1995).
CC -!- FUNCTION: High affinity receptor for melatonin. The activity of this
CC receptor is mediated by pertussis toxin sensitive G proteins that
CC inhibits adenylate cyclase activity (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Brain and kidney, with trace levels in lungs.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; U30609; AAA85098.1; -; mRNA.
DR PIR; S72554; S72554.
DR RefSeq; NP_001280032.1; NM_001293103.1.
DR AlphaFoldDB; P51050; -.
DR SMR; P51050; -.
DR STRING; 9031.ENSGALP00000027791; -.
DR BindingDB; P51050; -.
DR ChEMBL; CHEMBL4466; -.
DR DrugCentral; P51050; -.
DR PaxDb; P51050; -.
DR GeneID; 396338; -.
DR KEGG; gga:396338; -.
DR CTD; 4544; -.
DR VEuPathDB; HostDB:geneid_396338; -.
DR eggNOG; KOG3656; Eukaryota.
DR HOGENOM; CLU_009579_3_3_1; -.
DR InParanoid; P51050; -.
DR OrthoDB; 907115at2759; -.
DR PhylomeDB; P51050; -.
DR TreeFam; TF331693; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0008502; F:melatonin receptor activity; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR002278; Mel_1A/1B_rcpt.
DR InterPro; IPR000025; Melatonin_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01149; MELATONIN1AR.
DR PRINTS; PR00857; MELATONINR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN <1..289
FT /note="Melatonin receptor type 1B"
FT /id="PRO_0000069873"
FT TOPO_DOM <1..2
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 3..23
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 24..41
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..62
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 63..81
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..126
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..147
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 148..179
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..200
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 201..213
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 214..234
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 235..289
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 264..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 39..116
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT NON_TER 1
SQ SEQUENCE 289 AA; 33001 MW; 08F0B3EC1BFB3FF1 CRC64;
GNAFVVSLAL ADLVVALYPY PLVLLAIFHN GWTLGEMHCK VSGFVMGLSV IGSIFNITAI
AINRYCYICH SFAYDKVYSC WNTMLYVSLI WVLTVIATVP NFFVGSLKYD PRIYSCTFVQ
TASSYYTIAV VVIHFIVPIT VVSFCYLRIW VLVLQVRRRV KSETKPRLKP SDFRNFLTMF
VVFVIFAFCW APLNFIGLAV AINPSEMAPK VPEWLFIISY FMAYFNSCLN AIIYGLLNQN
FRNEYKRILM SLWMPRLFFQ DTSKGGTDGQ KSKPSPALNN NDQMKTDTL
