MTR1C_DANRE
ID MTR1C_DANRE Reviewed; 151 AA.
AC P51052;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Melatonin receptor type 1C;
DE Short=Mel-1C-R;
DE Short=Mel1C receptor;
DE AltName: Full=Melatonin receptor Mel1C Z2.3;
DE Flags: Fragment;
GN Name=mtnr1c; Synonyms=mel1c;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7576645; DOI=10.1016/0896-6273(95)90090-x;
RA Reppert S.M., Weaver D.R., Cassone V.M., Godson C., Kolakowski L.F. Jr.;
RT "Melatonin receptors are for the birds: molecular analysis of two receptor
RT subtypes differentially expressed in chick brain.";
RL Neuron 15:1003-1015(1995).
CC -!- FUNCTION: High affinity receptor for melatonin. The activity of this
CC receptor is mediated by pertussis toxin sensitive G proteins that
CC inhibits adenylate cyclase activity (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; U31825; AAA92497.1; -; mRNA.
DR AlphaFoldDB; P51052; -.
DR SMR; P51052; -.
DR STRING; 7955.ENSDARP00000106863; -.
DR PaxDb; P51052; -.
DR ZFIN; ZDB-GENE-990415-158; mtnr1c.
DR eggNOG; KOG3656; Eukaryota.
DR InParanoid; P51052; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0008502; F:melatonin receptor activity; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR002280; Mel_rcpt_1X.
DR InterPro; IPR000025; Melatonin_rcpt.
DR PANTHER; PTHR24228:SF56; PTHR24228:SF56; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00857; MELATONINR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN <1..>151
FT /note="Melatonin receptor type 1C"
FT /id="PRO_0000069875"
FT TOPO_DOM <1..13
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 14..34
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 35..58
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..79
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..109
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 131..143
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..>151
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT NON_TER 1
FT NON_TER 151
SQ SEQUENCE 151 AA; 17277 MW; C52F1724232826C0 CRC64;
CHSLRYDRLY SRRNTCLYLL LTWMLTALAT VPNFLVGSLK YDPRVFSCTF TQTASSSYTV
CVVLIHFLVP LGVVSFCYLR IWTLVIRVKG RVRPNPKVRA ADLRNFLTMF VVFVLFAVCW
APLNFIGLAV AINPAKVAPN IPEWLFVTSY F
