MTR1L_MOUSE
ID MTR1L_MOUSE Reviewed; 591 AA.
AC O88495; Q3V1S8;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 16-OCT-2013, sequence version 3.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Melatonin-related receptor;
DE AltName: Full=G protein-coupled receptor 50;
DE AltName: Full=H9;
GN Name=Gpr50;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9933574; DOI=10.1006/geno.1998.5661;
RA Gubitz A.K., Reppert S.M.;
RT "Assignment of the melatonin-related receptor to human chromosome X (GPR50)
RT and mouse chromosome X (Gpr50).";
RL Genomics 55:248-251(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Extraembryonic tissue, and Placenta;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Does not bind melatonin.
CC -!- SUBUNIT: Homodimer, and heterodimer with MTNR1A and MTNR1B.
CC {ECO:0000250}.
CC -!- INTERACTION:
CC O88495; Q8CHK4: Kat5; NbExp=3; IntAct=EBI-21227860, EBI-1169948;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-9 is the initiator.
CC {ECO:0000305}.
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DR EMBL; AF065145; AAC21462.1; -; mRNA.
DR EMBL; AK132272; BAE21072.1; -; mRNA.
DR EMBL; AL840624; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466624; EDL26572.1; -; Genomic_DNA.
DR EMBL; BC137982; AAI37983.1; -; mRNA.
DR CCDS; CCDS30181.1; -.
DR RefSeq; NP_001295430.1; NM_001308501.1.
DR RefSeq; NP_034470.1; NM_010340.2.
DR AlphaFoldDB; O88495; -.
DR SMR; O88495; -.
DR IntAct; O88495; 8.
DR STRING; 10090.ENSMUSP00000064608; -.
DR iPTMnet; O88495; -.
DR PhosphoSitePlus; O88495; -.
DR PaxDb; O88495; -.
DR PeptideAtlas; O88495; -.
DR PRIDE; O88495; -.
DR ProteomicsDB; 291367; -.
DR Antibodypedia; 7082; 305 antibodies from 34 providers.
DR DNASU; 14765; -.
DR Ensembl; ENSMUST00000070449; ENSMUSP00000064608; ENSMUSG00000056380.
DR GeneID; 14765; -.
DR KEGG; mmu:14765; -.
DR UCSC; uc009tke.1; mouse.
DR CTD; 9248; -.
DR MGI; MGI:1333877; Gpr50.
DR VEuPathDB; HostDB:ENSMUSG00000056380; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000160515; -.
DR HOGENOM; CLU_468199_0_0_1; -.
DR InParanoid; O88495; -.
DR OMA; GHHKSVF; -.
DR OrthoDB; 907115at2759; -.
DR PhylomeDB; O88495; -.
DR TreeFam; TF331693; -.
DR BioGRID-ORCS; 14765; 1 hit in 74 CRISPR screens.
DR PRO; PR:O88495; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; O88495; protein.
DR Bgee; ENSMUSG00000056380; Expressed in median eminence of neurohypophysis and 79 other tissues.
DR Genevisible; O88495; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0008502; F:melatonin receptor activity; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR002280; Mel_rcpt_1X.
DR InterPro; IPR000025; Melatonin_rcpt.
DR PANTHER; PTHR24228:SF56; PTHR24228:SF56; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01151; MELATONIN1XR.
DR PRINTS; PR00857; MELATONINR.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..591
FT /note="Melatonin-related receptor"
FT /id="PRO_0000069879"
FT TOPO_DOM 1..38
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 60..72
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 94..111
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..132
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 133..151
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..172
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 173..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..247
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 248..268
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 269..281
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 282..302
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 303..591
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 378..427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 109..186
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 591 AA; 65130 MW; 12576D50C20E216A CRC64;
MATVPKSNMG PTKAVPTPFG CIGCKLPKPD YPPALIIFMF CAMVITVVVD LIGNSMVILA
VTKNKKLRNS GNIFVASLSV ADMLVAIYPY PLMLYAMSVG GWDLSQLQCQ MVGLVTGLSV
VGSIFNITAI AINRYCYICH SLQYKRIFSL RNTCIYLVVT WVMTVLAVLP NMYIGTIEYD
PRTYTCIFNY VNNPAFTVTI VCIHFVLPLI IVGYCYTKIW IKVLAARDPA GQNPDNQFAE
VRNFLTMFVI FLLFAVCWCP VNVLTVLVAV IPKEMAGKIP NWLYLAAYCI AYFNSCLNAI
IYGILNESFR REYWTIFHAM RHPILFISHL ISDIRETWET RALTRARVRA RDQVREQERA
RACVAVEGTP RNVRNVLLPG DASAPHSDRA SVRPKPQTRS TSVYRKPASI HHKSISGHPK
SASVYPKPAS SVHCKPASVH FKPASVHFKG DSVYFKGDTV HYRAASKLVT SHRISAGPST
SHPTSMAGYI KSGTSHPATT TVDYLEPATT SHSVLTAVDL PEVSASHCLE MTSTGHLRAD
ISASVLPSVP FELAATPPDT TAIPIASGDY RKVVLIDDDS DDSDCSDEMA V
