MTR1L_RAT
ID MTR1L_RAT Reviewed; 119 AA.
AC Q62953;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 25-MAY-2022, entry version 115.
DE RecName: Full=Melatonin-related receptor;
DE AltName: Full=G protein-coupled receptor 50;
DE AltName: Full=H9;
DE Flags: Fragment;
GN Name=Gpr50;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8647286; DOI=10.1016/0014-5793(96)00437-1;
RA Reppert S.M., Weaver D.R., Ebisawa T., Mahle C.D., Kolakowski L.F. Jr.;
RT "Cloning of a melatonin-related receptor from human pituitary.";
RL FEBS Lett. 386:219-224(1996).
CC -!- FUNCTION: Does not bind melatonin. {ECO:0000250}.
CC -!- SUBUNIT: Homodimer, and heterodimer with MTNR1A and MTNR1B.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; U52218; AAC52671.1; -; mRNA.
DR AlphaFoldDB; Q62953; -.
DR SMR; Q62953; -.
DR STRING; 10116.ENSRNOP00000015147; -.
DR RGD; 619863; Gpr50.
DR eggNOG; KOG3656; Eukaryota.
DR InParanoid; Q62953; -.
DR PhylomeDB; Q62953; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0008502; F:melatonin receptor activity; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR002280; Mel_rcpt_1X.
DR InterPro; IPR000025; Melatonin_rcpt.
DR PANTHER; PTHR24228:SF56; PTHR24228:SF56; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR01151; MELATONIN1XR.
DR PRINTS; PR00857; MELATONINR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN <1..>119
FT /note="Melatonin-related receptor"
FT /id="PRO_0000069880"
FT TOPO_DOM <1..17
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 18..38
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 39..62
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 63..83
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 84..113
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..>119
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT NON_TER 1
FT NON_TER 119
SQ SEQUENCE 119 AA; 13837 MW; 1C621DDDDB2D8386 CRC64;
YCYICHSLQY NADLQPANTC IYLVVTWVMT VLDVLPNVYI GTIEYDPRTY TCYFNYVNNP
AFTVTIVCIH FVLPLIIVGY CYTKIWIKVL ADRDPAGQNP DNQFAEVRNF LTMFVIFLL
