ID   MTR3_CHATD              Reviewed;         284 AA.
AC   P0CT46;
DT   19-FEB-2014, integrated into UniProtKB/Swiss-Prot.
DT   19-FEB-2014, sequence version 1.
DT   03-AUG-2022, entry version 17.
DE   RecName: Full=Exosome complex component MTR3;
DE   AltName: Full=mRNA transport regulator 3;
GN   Name=MTR3; ORFNames=CTHT_0115690;
OS   Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=759272;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 1495 / CBS 144.50 / IMI 039719;
RX   PubMed=21784248; DOI=10.1016/j.cell.2011.06.039;
RA   Amlacher S., Sarges P., Flemming D., van Noort V., Kunze R., Devos D.P.,
RA   Arumugam M., Bork P., Hurt E.;
RT   "Insight into structure and assembly of the nuclear pore complex by
RT   utilizing the genome of a eukaryotic thermophile.";
RL   Cell 146:277-289(2011).
CC   -!- FUNCTION: Non-catalytic component of the RNA exosome complex which has
CC       3'->5' exoribonuclease activity and participates in a multitude of
CC       cellular RNA processing and degradation events. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the RNA exosome complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus, nucleolus
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RNase PH family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; GL988041; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; P0CT46; -.
DR   SMR; P0CT46; -.
DR   STRING; 759272.P0CT46; -.
DR   Proteomes; UP000008066; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000176; C:nuclear exosome (RNase complex); IEA:UniProt.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.230.70; -; 1.
DR   InterPro; IPR001247; ExoRNase_PH_dom1.
DR   InterPro; IPR036345; ExoRNase_PH_dom2_sf.
DR   InterPro; IPR027408; PNPase/RNase_PH_dom_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   Pfam; PF01138; RNase_PH; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55666; SSF55666; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Exosome; Nucleus; Reference proteome; RNA-binding;
KW   rRNA processing.
FT   CHAIN           1..284
FT                   /note="Exosome complex component MTR3"
FT                   /id="PRO_0000425284"
SQ   SEQUENCE   284 AA;  30506 MW;  67049CB9221B25A5 CRC64;
     MTDRRRINGP AGATIPPVYE DSGISEVKAL KIRSRPSNII RKIYLKTGVT PSASGSAYLE
     LETSANSGVS GLKLSCTVHG PRSLPRSSPF SPHMVVSTHV KYAPFATKQR RGYLRDPTER
     DLGIHLEAAL RGAIIADRWP KSGVDIIISI IEGDQDREAS KTQGDEVWDM MNTLSGCITV
     ASAALADAGI DCVDTVAGGV AALVQDSDGS PEIVVDPIPS EHRKILAACC VAYLPMRDEV
     TNLWFRGDLP ASDMDLYTEL VEKGIQASRS ANRVLVDCLT ETVG