ID   MTR4_CAEEL              Reviewed;        1026 AA.
AC   Q23223;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 142.
DE   RecName: Full=mRNA transport homolog 4;
DE   AltName: Full=Uncharacterized helicase W08D2.7;
DE            EC=3.6.4.-;
GN   Name=mtr-4; ORFNames=W08D2.7;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the helicase family. SKI2 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; Z70271; CAA94235.1; -; Genomic_DNA.
DR   PIR; T26282; T26282.
DR   RefSeq; NP_501757.1; NM_069356.5.
DR   AlphaFoldDB; Q23223; -.
DR   SMR; Q23223; -.
DR   BioGRID; 42928; 11.
DR   STRING; 6239.W08D2.7; -.
DR   EPD; Q23223; -.
DR   PaxDb; Q23223; -.
DR   PeptideAtlas; Q23223; -.
DR   EnsemblMetazoa; W08D2.7.1; W08D2.7.1; WBGene00012342.
DR   GeneID; 177824; -.
DR   KEGG; cel:CELE_W08D2.7; -.
DR   CTD; 177824; -.
DR   WormBase; W08D2.7; CE06562; WBGene00012342; mtr-4.
DR   eggNOG; KOG0948; Eukaryota.
DR   GeneTree; ENSGT00940000156183; -.
DR   HOGENOM; CLU_002902_0_1_1; -.
DR   InParanoid; Q23223; -.
DR   OMA; IMLKNYN; -.
DR   OrthoDB; 176060at2759; -.
DR   PhylomeDB; Q23223; -.
DR   Reactome; R-CEL-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:Q23223; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00012342; Expressed in embryo and 4 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003724; F:RNA helicase activity; IBA:GO_Central.
DR   GO; GO:0000460; P:maturation of 5.8S rRNA; IBA:GO_Central.
DR   GO; GO:0006401; P:RNA catabolic process; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR025696; rRNA_proc-arch_dom.
DR   InterPro; IPR016438; Ski2-like.
DR   InterPro; IPR012961; Ski2_C.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF08148; DSHCT; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF13234; rRNA_proc-arch; 1.
DR   PIRSF; PIRSF005198; Antiviral_helicase_SKI2; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM01142; DSHCT; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Helicase; Hydrolase; Nucleotide-binding; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..1026
FT                   /note="mRNA transport homolog 4"
FT                   /id="PRO_0000102097"
FT   DOMAIN          134..290
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   DOMAIN          360..564
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT   MOTIF           238..241
FT                   /note="DEIH box"
FT   BINDING         147..154
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ   SEQUENCE   1026 AA;  116370 MW;  7AC420E41222A92E CRC64;
     MADLFDEFIE PGVKNEIMDV EEAPENPMEK LDSAKKRQAR EDMTNLLANM HNDVGVGNFD
     EATSKRARVE EEEEVEEARM ENIIVHTIRT DNENCTHEVA IPPNAEFAEL RENSGTEPAK
     YYPFQLDAFQ KQAILCIDNN QSVLVSAHTS AGKTVVATYA IAKCLREKQR VIYTSPIKAL
     SNQKYRELEE EFKDVGLMTG DVTLNPDASC LVMTTEILRS MLYRGSEIMK EVGWVVYDEI
     HYMRDKERGV VWEETIILMS KNIKQAFLSA TIPNARQFAQ WVASIKQQPV NVVYTDYRPT
     PLQHWIYPVG GEGMYEVVNV KGEFREDKFR DAMSGLATAG DSAGSFNKRR TGGGTQGDSN
     VLKIIRSVAS NDGLNCIVFS FSRKECESYA ISLKDMDFNK DHEKGMVKSV YESAIAQLSP
     EDQKLPQILN ILPLLRRGIG VHHSGLMPIL KETIEILFGE GLVKVLFATE TFSMGLNMPA
     RTVVFTSARK FDGSDNRYIT SGEYIQMAGR AGRRGKDDRG TVILMVDSAM SADDAKQIIK
     GATDPLNSQF RLTYNMVLNL MRVEGMAVSW IINNSFHQFQ SYAKIPEIDK KCVQVERKIA
     SFNFPWENEM RTLVDLQDQL EATRQRIIQI QREPKYIVGF LHAGRLFKVK SGDRDFKWGI
     LNQFKKEQNP DDRNDQIYLC DMMIAINTEG RFDPTNPATL VPGFDLPKRR WIRVPMTIDR
     ITAISAVRLK VPADIDKPDG QMRLDGMMAA ATKRFGNQIP LLDPIQDMEI KTVEMKELIA
     REKSLEGRLE THSMTKRDNM KDLKKQFEQK QDAVKELNAL KAERKSVQST LHLEELNNRK
     RVLRRLGYLG NDDALVLKGS VACELSASDE LILTEMLLKG IFNTLDVAQT AALLSCFVFQ
     DKCAAPKLAT ELQTCLSELH EQARNVAKVS NECKMEVMED KYVSSFNPGL MDVVYQWVNG
     ATFSEIVKTT DVFEGSIIRT LRRLEEVLRE MINAAKALAN KELEQKFEDA RKNLKRDIVF
     AASLYL