位置:首页 > 蛋白库 > MTRA2_METRM
MTRA2_METRM
ID   MTRA2_METRM             Reviewed;         193 AA.
AC   D3E0P6;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   23-MAR-2010, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Tetrahydromethanopterin S-methyltransferase subunit A 2 {ECO:0000255|HAMAP-Rule:MF_01093};
DE            EC=2.1.1.86 {ECO:0000255|HAMAP-Rule:MF_01093};
DE   AltName: Full=N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit A 2 {ECO:0000255|HAMAP-Rule:MF_01093};
GN   Name=mtrA2 {ECO:0000255|HAMAP-Rule:MF_01093}; OrderedLocusNames=mru_0441;
OS   Methanobrevibacter ruminantium (strain ATCC 35063 / DSM 1093 / JCM 13430 /
OS   OCM 146 / M1) (Methanobacterium ruminantium).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanobrevibacter.
OX   NCBI_TaxID=634498;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35063 / DSM 1093 / JCM 13430 / OCM 146 / M1;
RX   PubMed=20126622; DOI=10.1371/journal.pone.0008926;
RA   Leahy S.C., Kelly W.J., Altermann E., Ronimus R.S., Yeoman C.J.,
RA   Pacheco D.M., Li D., Kong Z., McTavish S., Sang C., Lambie S.C.,
RA   Janssen P.H., Dey D., Attwood G.T.;
RT   "The genome sequence of the rumen methanogen Methanobrevibacter ruminantium
RT   reveals new possibilities for controlling ruminant methane emissions.";
RL   PLoS ONE 5:E8926-E8926(2010).
CC   -!- FUNCTION: Part of a complex that catalyzes the formation of methyl-
CC       coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-
CC       tetrahydromethanopterin. This is an energy-conserving, sodium-ion
CC       translocating step. {ECO:0000255|HAMAP-Rule:MF_01093}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2
CC         Na(+)(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2
CC         Na(+)(out); Xref=Rhea:RHEA:53492, ChEBI:CHEBI:29101,
CC         ChEBI:CHEBI:58103, ChEBI:CHEBI:58116, ChEBI:CHEBI:58286,
CC         ChEBI:CHEBI:58319; EC=2.1.1.86; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01093};
CC   -!- COFACTOR:
CC       Name=5-hydroxybenzimidazolylcob(I)amide; Xref=ChEBI:CHEBI:60494;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01093};
CC       Note=Binds 1 5-hydroxybenzimidazolylcobamide group. {ECO:0000255|HAMAP-
CC       Rule:MF_01093};
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); methyl-
CC       coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step
CC       2/2. {ECO:0000255|HAMAP-Rule:MF_01093}.
CC   -!- SUBUNIT: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD,
CC       MtrE, MtrF, MtrG and MtrH. {ECO:0000255|HAMAP-Rule:MF_01093}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01093};
CC       Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01093}.
CC   -!- SIMILARITY: Belongs to the MtrA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01093}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP001719; ADC46292.1; -; Genomic_DNA.
DR   RefSeq; WP_012955243.1; NC_013790.1.
DR   AlphaFoldDB; D3E0P6; -.
DR   SMR; D3E0P6; -.
DR   STRING; 634498.mru_0441; -.
DR   EnsemblBacteria; ADC46292; ADC46292; mru_0441.
DR   GeneID; 8770081; -.
DR   KEGG; mru:mru_0441; -.
DR   PATRIC; fig|634498.28.peg.443; -.
DR   eggNOG; arCOG03221; Archaea.
DR   HOGENOM; CLU_100863_1_0_2; -.
DR   OMA; ARMKIVS; -.
DR   OrthoDB; 89197at2157; -.
DR   UniPathway; UPA00640; UER00698.
DR   Proteomes; UP000008680; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0050897; F:cobalt ion binding; IEA:InterPro.
DR   GO; GO:0030269; F:tetrahydromethanopterin S-methyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006814; P:sodium ion transport; IEA:InterPro.
DR   HAMAP; MF_01093; MtrA; 1.
DR   InterPro; IPR030688; MeTrfase_MtrA/MtxA.
DR   InterPro; IPR005778; MtrA.
DR   Pfam; PF04208; MtrA; 1.
DR   PIRSF; PIRSF500207; MtrA; 1.
DR   PIRSF; PIRSF009452; MtrA_MtxA; 1.
DR   TIGRFAMs; TIGR01111; mtrA; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Cobalt; Membrane; Methanogenesis; Methyltransferase;
KW   One-carbon metabolism; Reference proteome; Transferase; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..193
FT                   /note="Tetrahydromethanopterin S-methyltransferase subunit
FT                   A 2"
FT                   /id="PRO_0000403060"
FT   TOPO_DOM        1..38
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01093"
FT   TRANSMEM        39..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01093"
FT   TOPO_DOM        59..193
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01093"
FT   REGION          174..193
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         84
FT                   /ligand="5-hydroxybenzimidazolylcob(I)amide"
FT                   /ligand_id="ChEBI:CHEBI:60494"
FT                   /ligand_note="cofactor"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01093"
SQ   SEQUENCE   193 AA;  20713 MW;  D126A067DFD95C74 CRC64;
     MADKKPTAEN WPVVSGDYIV GDPESPVAVT TLASHNEDIP AAAGAAIAGP CKTENLGIEK
     VVANIISNPN IRFLILCGAE VQGHITGQSF KALYENGCDP EKKKITGATG AIPFVENIPM
     EGVERFQQQL ELVDMIDNED GGAITAKVKE CIEKDPGAFE EDSLVIKIDE ERYSKKSSFV
     ESSSESEKIE SEA
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024