MTRAA_XENLA
ID MTRAA_XENLA Reviewed; 765 AA.
AC Q5U581;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 68.
DE RecName: Full=Myotubularin-related protein 10-A;
DE AltName: Full=Inactive phosphatidylinositol 3-phosphatase 10-A {ECO:0000305};
GN Name=mtmr10-a;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000305}.
CC -!- CAUTION: Although it belongs to the non-receptor class myotubularin
CC subfamily, lacks the conserved active site cysteine residue at position
CC 391 in the dsPTPase catalytic loop, suggesting that it has no
CC phosphatase activity. {ECO:0000305}.
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DR EMBL; BC084803; AAH84803.1; -; mRNA.
DR RefSeq; NP_001088476.1; NM_001095007.1.
DR AlphaFoldDB; Q5U581; -.
DR SMR; Q5U581; -.
DR DNASU; 495341; -.
DR GeneID; 495341; -.
DR KEGG; xla:495341; -.
DR CTD; 495341; -.
DR Xenbase; XB-GENE-1002521; mtmr10.S.
DR OrthoDB; 620702at2759; -.
DR Proteomes; UP000186698; Chromosome 3S.
DR Bgee; 495341; Expressed in kidney and 19 other tissues.
DR CDD; cd13346; PH-GRAM_MTMR10; 1.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR030573; MTMR10.
DR InterPro; IPR036004; MTMR10_PH-GRAM.
DR InterPro; IPR022587; MTMR12-like_C.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR PANTHER; PTHR10807; PTHR10807; 1.
DR PANTHER; PTHR10807:SF39; PTHR10807:SF39; 1.
DR Pfam; PF12578; 3-PAP; 1.
DR Pfam; PF06602; Myotub-related; 2.
DR SUPFAM; SSF52799; SSF52799; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..765
FT /note="Myotubularin-related protein 10-A"
FT /id="PRO_0000284363"
FT DOMAIN 209..650
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00669"
SQ SEQUENCE 765 AA; 88113 MW; 89E4B64712513599 CRC64;
MFSLKQPKPS FRSYLLPPQQ EDKLNPETKI KKLKAVLLPG EIVVNEVNFV RKCIASDTSQ
YDLWGKLICT NFKISFITEN SVPFQRFHYK NLLLGEHDVP LTCIEQIVVV NDTKRKQKIL
SHNQKLKFNP TELIIYCKDF RILRFRFDEA GPESAKKVCL ALAHYSQPTD LQLLFAFEYV
AQMYHKPEYK VNGIDPGGGG DFCQRTPLFE TYSDWDREIK RTGASDWRVC SVNEGYMIST
CLPEYFVVPS SLADQDLKQY SHAFVGRRMP LWCWNHSNGS ALVRMASIKD LLQQRKIGQR
VCSGITRSHP LRSDVYKCDL DHNVPSIQDI QAAFSKLRQL CVNEPFDETE EKWLSSLENA
QWLEFVRTFL KQAAELAYVL DFSRRSVVLQ EEEGRDVSCL VASLVQLMLD PYFRTIVGFQ
SLIQKEWVMS AYPFLDRCNH LKRSEKESPL FVLFLDCVWQ LLQQYPAAFQ FTETYLTVLH
DSTRISLFGT FLFNSPHQRV QQSTEFAIAR NIQLGEEKGL KFPSVWDWSL QFSAKDRALF
NNPLYIGKSV PCVQNGAVKS FKRTKNYSST MRGMPPSVKN GMAIQQDFMP RRNSLILKLK
PEILQQVPVI IPSSGFEQYL RDWFTKPADL HGVILPCLHG THIKLWKLCY LRWTPEAQIN
HGGFITAFHK ISLLASEIEL LQSRLRQYRA YPLSTVTSPV GEQNRMFFRP DELHSSNGSL
DILTSSFPFS PIGNLCRRSI LGTPLSKFIN GAKIWLSTET LANED