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MTRAA_XENLA
ID   MTRAA_XENLA             Reviewed;         765 AA.
AC   Q5U581;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Myotubularin-related protein 10-A;
DE   AltName: Full=Inactive phosphatidylinositol 3-phosphatase 10-A {ECO:0000305};
GN   Name=mtmr10-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC       receptor class myotubularin subfamily. {ECO:0000305}.
CC   -!- CAUTION: Although it belongs to the non-receptor class myotubularin
CC       subfamily, lacks the conserved active site cysteine residue at position
CC       391 in the dsPTPase catalytic loop, suggesting that it has no
CC       phosphatase activity. {ECO:0000305}.
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DR   EMBL; BC084803; AAH84803.1; -; mRNA.
DR   RefSeq; NP_001088476.1; NM_001095007.1.
DR   AlphaFoldDB; Q5U581; -.
DR   SMR; Q5U581; -.
DR   DNASU; 495341; -.
DR   GeneID; 495341; -.
DR   KEGG; xla:495341; -.
DR   CTD; 495341; -.
DR   Xenbase; XB-GENE-1002521; mtmr10.S.
DR   OrthoDB; 620702at2759; -.
DR   Proteomes; UP000186698; Chromosome 3S.
DR   Bgee; 495341; Expressed in kidney and 19 other tissues.
DR   CDD; cd13346; PH-GRAM_MTMR10; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR030573; MTMR10.
DR   InterPro; IPR036004; MTMR10_PH-GRAM.
DR   InterPro; IPR022587; MTMR12-like_C.
DR   InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR   InterPro; IPR030564; Myotubularin_fam.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   PANTHER; PTHR10807; PTHR10807; 1.
DR   PANTHER; PTHR10807:SF39; PTHR10807:SF39; 1.
DR   Pfam; PF12578; 3-PAP; 1.
DR   Pfam; PF06602; Myotub-related; 2.
DR   SUPFAM; SSF52799; SSF52799; 1.
DR   PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..765
FT                   /note="Myotubularin-related protein 10-A"
FT                   /id="PRO_0000284363"
FT   DOMAIN          209..650
FT                   /note="Myotubularin phosphatase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00669"
SQ   SEQUENCE   765 AA;  88113 MW;  89E4B64712513599 CRC64;
     MFSLKQPKPS FRSYLLPPQQ EDKLNPETKI KKLKAVLLPG EIVVNEVNFV RKCIASDTSQ
     YDLWGKLICT NFKISFITEN SVPFQRFHYK NLLLGEHDVP LTCIEQIVVV NDTKRKQKIL
     SHNQKLKFNP TELIIYCKDF RILRFRFDEA GPESAKKVCL ALAHYSQPTD LQLLFAFEYV
     AQMYHKPEYK VNGIDPGGGG DFCQRTPLFE TYSDWDREIK RTGASDWRVC SVNEGYMIST
     CLPEYFVVPS SLADQDLKQY SHAFVGRRMP LWCWNHSNGS ALVRMASIKD LLQQRKIGQR
     VCSGITRSHP LRSDVYKCDL DHNVPSIQDI QAAFSKLRQL CVNEPFDETE EKWLSSLENA
     QWLEFVRTFL KQAAELAYVL DFSRRSVVLQ EEEGRDVSCL VASLVQLMLD PYFRTIVGFQ
     SLIQKEWVMS AYPFLDRCNH LKRSEKESPL FVLFLDCVWQ LLQQYPAAFQ FTETYLTVLH
     DSTRISLFGT FLFNSPHQRV QQSTEFAIAR NIQLGEEKGL KFPSVWDWSL QFSAKDRALF
     NNPLYIGKSV PCVQNGAVKS FKRTKNYSST MRGMPPSVKN GMAIQQDFMP RRNSLILKLK
     PEILQQVPVI IPSSGFEQYL RDWFTKPADL HGVILPCLHG THIKLWKLCY LRWTPEAQIN
     HGGFITAFHK ISLLASEIEL LQSRLRQYRA YPLSTVTSPV GEQNRMFFRP DELHSSNGSL
     DILTSSFPFS PIGNLCRRSI LGTPLSKFIN GAKIWLSTET LANED
 
 
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