MTRA_MYCBO
ID MTRA_MYCBO Reviewed; 228 AA.
AC P0A5Z5; A0A1R3Y3J6; Q50447; X2BNU1;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2017, sequence version 2.
DT 25-MAY-2022, entry version 96.
DE RecName: Full=DNA-binding response regulator MtrA;
GN Name=mtrA; OrderedLocusNames=BQ2027_MB3274C;
OS Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=233413;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-935 / AF2122/97;
RX PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT "The complete genome sequence of Mycobacterium bovis.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=ATCC BAA-935 / AF2122/97;
RX PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA Robbe-Austerman S., Gordon S.V.;
RT "Updated reference genome sequence and annotation of Mycobacterium bovis
RT AF2122/97.";
RL Genome Announc. 5:E00157-E00157(2017).
CC -!- FUNCTION: Member of the two-component regulatory system MtrA/MtrB.
CC {ECO:0000250}.
CC -!- PTM: Phosphorylated by MtrB. {ECO:0000305}.
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DR EMBL; LT708304; SIU01903.1; -; Genomic_DNA.
DR RefSeq; NP_856919.1; NC_002945.3.
DR RefSeq; WP_003899985.1; NC_002945.4.
DR AlphaFoldDB; P0A5Z5; -.
DR SMR; P0A5Z5; -.
DR EnsemblBacteria; SIU01903; SIU01903; BQ2027_MB3274C.
DR GeneID; 45427240; -.
DR PATRIC; fig|233413.5.peg.3601; -.
DR OMA; NIHGEGF; -.
DR Proteomes; UP000001419; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00383; trans_reg_C; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR039420; WalR-like.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR48111; PTHR48111; 1.
DR Pfam; PF00072; Response_reg; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR SMART; SM00448; REC; 1.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR PROSITE; PS51755; OMPR_PHOB; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 3: Inferred from homology;
KW DNA-binding; Phosphoprotein; Transcription; Transcription regulation;
KW Two-component regulatory system.
FT CHAIN 1..228
FT /note="DNA-binding response regulator MtrA"
FT /id="PRO_0000081144"
FT DOMAIN 7..120
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT DNA_BIND 128..227
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT MOD_RES 56
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 228 AA; 25279 MW; 925DEBC495DFD5B6 CRC64;
MDTMRQRILV VDDDASLAEM LTIVLRGEGF DTAVIGDGTQ ALTAVRELRP DLVLLDLMLP
GMNGIDVCRV LRADSGVPIV MLTAKTDTVD VVLGLESGAD DYIMKPFKPK ELVARVRARL
RRNDDEPAEM LSIADVEIDV PAHKVTRNGE QISLTPLEFD LLVALARKPR QVFTRDVLLE
QVWGYRHPAD TRLVNVHVQR LRAKVEKDPE NPTVVLTVRG VGYKAGPP
