MTRA_MYCLE
ID MTRA_MYCLE Reviewed; 225 AA.
AC Q9CCJ2;
DT 25-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT 25-MAR-2003, sequence version 2.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=DNA-binding response regulator MtrA;
GN Name=mtrA; OrderedLocusNames=ML0773;
OS Mycobacterium leprae (strain TN).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=272631;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TN;
RX PubMed=11234002; DOI=10.1038/35059006;
RA Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA Barrell B.G.;
RT "Massive gene decay in the leprosy bacillus.";
RL Nature 409:1007-1011(2001).
CC -!- FUNCTION: Member of the two-component regulatory system MtrA/MtrB.
CC {ECO:0000250}.
CC -!- PTM: Phosphorylated by MtrB. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAC30282.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AL583919; CAC30282.1; ALT_INIT; Genomic_DNA.
DR PIR; F87005; F87005.
DR RefSeq; WP_010907921.1; NC_002677.1.
DR AlphaFoldDB; Q9CCJ2; -.
DR SMR; Q9CCJ2; -.
DR STRING; 272631.ML0773; -.
DR EnsemblBacteria; CAC30282; CAC30282; CAC30282.
DR KEGG; mle:ML0773; -.
DR Leproma; ML0773; -.
DR eggNOG; COG0745; Bacteria.
DR HOGENOM; CLU_000445_30_4_11; -.
DR Proteomes; UP000000806; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00383; trans_reg_C; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR039420; WalR-like.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR48111; PTHR48111; 1.
DR Pfam; PF00072; Response_reg; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR SMART; SM00448; REC; 1.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR PROSITE; PS51755; OMPR_PHOB; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 3: Inferred from homology;
KW DNA-binding; Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation; Two-component regulatory system.
FT CHAIN 1..225
FT /note="DNA-binding response regulator MtrA"
FT /id="PRO_0000081141"
FT DOMAIN 4..117
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT DNA_BIND 125..224
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT MOD_RES 53
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 225 AA; 24927 MW; B04A11DA2C5CECCF CRC64;
MRQRILVVDD DASLAEMLTI VLRGEGFDTA VIGDGTQALT AVRELRPDLV LLDLMLPGMN
GIDVCRVLRA DSGVPIVMLT AKTDTVDVVL GLESGADDYI MKPFKPKELV ARVRARLRRN
DDEPAEMLSI ADVDIDVPAH KVTRNGEHIS LTPLEFDLLV ALARKPRQVF TRDVLLEQVW
GYRHPADTRL VNVHVQRLRA KVEKDPENPT VVLTVRGVGY KAGPP
