MTRA_MYCPA
ID MTRA_MYCPA Reviewed; 225 AA.
AC Q93CB8;
DT 25-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2004, sequence version 2.
DT 25-MAY-2022, entry version 109.
DE RecName: Full=DNA-binding response regulator MtrA;
GN Name=mtrA; OrderedLocusNames=MAP_3360c;
OS Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)
OS (Mycobacterium paratuberculosis).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium avium complex (MAC).
OX NCBI_TaxID=262316;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 19698 / CIP 103963 / DSM 44133 / TMC 807;
RA Urbanic K.W., Mutharia L.M.;
RT "Identification and initial characterization of the mtrAB two-component
RT signal transduction system of Mycobacterium avium subspecies
RT paratuberculosis.";
RL Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-968 / K-10;
RX PubMed=16116077; DOI=10.1073/pnas.0505662102;
RA Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N.,
RA Kanjilal S., Kapur V.;
RT "The complete genome sequence of Mycobacterium avium subspecies
RT paratuberculosis.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005).
CC -!- FUNCTION: Member of the two-component regulatory system MtrA/MtrB.
CC {ECO:0000250}.
CC -!- PTM: Phosphorylated by MtrB. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAS05910.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF410884; AAL10207.1; -; Genomic_DNA.
DR EMBL; AE016958; AAS05910.1; ALT_INIT; Genomic_DNA.
DR AlphaFoldDB; Q93CB8; -.
DR SMR; Q93CB8; -.
DR STRING; 262316.MAP_3360c; -.
DR EnsemblBacteria; AAS05910; AAS05910; MAP_3360c.
DR KEGG; mpa:MAP_3360c; -.
DR eggNOG; COG0745; Bacteria.
DR HOGENOM; CLU_000445_30_4_11; -.
DR OMA; NIHGEGF; -.
DR Proteomes; UP000000580; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00383; trans_reg_C; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR039420; WalR-like.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR48111; PTHR48111; 1.
DR Pfam; PF00072; Response_reg; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR SMART; SM00448; REC; 1.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR PROSITE; PS51755; OMPR_PHOB; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 3: Inferred from homology;
KW DNA-binding; Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation; Two-component regulatory system.
FT CHAIN 1..225
FT /note="DNA-binding response regulator MtrA"
FT /id="PRO_0000081142"
FT DOMAIN 4..117
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT DNA_BIND 125..224
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT MOD_RES 53
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT CONFLICT 225
FT /note="P -> S (in Ref. 1; AAL10207)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 225 AA; 24932 MW; A345E62B3D42DEE3 CRC64;
MRQRILVVDD DASLAEMLTI VLRGEGFDTA VIGDGTQALT AVRELRPDLV LLDLMLPGMN
GIDVCRVLRA DSGVPIVMLT AKTDTVDVVL GLESGADDYI MKPFKPKELV ARVRARLRRN
DDEPAEMLSI ADVEIDVPAH KVTRNGEQIS LTPLEFDLLV ALARKPRQVF TRDVLLEQVW
GYRHPADTRL VNVHVQRLRA KVEKDPENPT VVLTVRGVGY KAGPP
