MTRC_METBF
ID MTRC_METBF Reviewed; 267 AA.
AC Q9Y8K2; Q46D19;
DT 28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2006, sequence version 2.
DT 25-MAY-2022, entry version 115.
DE RecName: Full=Tetrahydromethanopterin S-methyltransferase subunit C {ECO:0000255|HAMAP-Rule:MF_01096};
DE EC=2.1.1.86 {ECO:0000255|HAMAP-Rule:MF_01096};
DE AltName: Full=N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit C {ECO:0000255|HAMAP-Rule:MF_01096};
GN Name=mtrC {ECO:0000255|HAMAP-Rule:MF_01096}; OrderedLocusNames=Mbar_A1260;
OS Methanosarcina barkeri (strain Fusaro / DSM 804).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX NCBI_TaxID=269797;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10338124; DOI=10.1016/s0014-5793(99)00429-9;
RA Hippler B., Thauer R.K.;
RT "The energy conserving methyltetrahydromethanopterin:coenzyme M
RT methyltransferase complex from methanogenic archaea: function of the
RT subunit MtrH.";
RL FEBS Lett. 449:165-168(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Fusaro / DSM 804;
RX PubMed=16980466; DOI=10.1128/jb.00810-06;
RA Maeder D.L., Anderson I., Brettin T.S., Bruce D.C., Gilna P., Han C.S.,
RA Lapidus A., Metcalf W.W., Saunders E., Tapia R., Sowers K.R.;
RT "The Methanosarcina barkeri genome: comparative analysis with
RT Methanosarcina acetivorans and Methanosarcina mazei reveals extensive
RT rearrangement within methanosarcinal genomes.";
RL J. Bacteriol. 188:7922-7931(2006).
CC -!- FUNCTION: Part of a complex that catalyzes the formation of methyl-
CC coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-
CC tetrahydromethanopterin. This is an energy-conserving, sodium-ion
CC translocating step. {ECO:0000255|HAMAP-Rule:MF_01096}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2
CC Na(+)(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2
CC Na(+)(out); Xref=Rhea:RHEA:53492, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:58103, ChEBI:CHEBI:58116, ChEBI:CHEBI:58286,
CC ChEBI:CHEBI:58319; EC=2.1.1.86; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_01096};
CC -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); methyl-
CC coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step
CC 2/2. {ECO:0000255|HAMAP-Rule:MF_01096}.
CC -!- SUBUNIT: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD,
CC MtrE, MtrF, MtrG and MtrH. {ECO:0000255|HAMAP-Rule:MF_01096}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01096};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01096}.
CC -!- SIMILARITY: Belongs to the MtrC family. {ECO:0000255|HAMAP-
CC Rule:MF_01096}.
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DR EMBL; AJ132817; CAB41640.1; -; Genomic_DNA.
DR EMBL; CP000099; AAZ70223.1; -; Genomic_DNA.
DR RefSeq; WP_011306270.1; NC_007355.1.
DR AlphaFoldDB; Q9Y8K2; -.
DR STRING; 269797.Mbar_A1260; -.
DR EnsemblBacteria; AAZ70223; AAZ70223; Mbar_A1260.
DR GeneID; 3627860; -.
DR KEGG; mba:Mbar_A1260; -.
DR eggNOG; arCOG04868; Archaea.
DR HOGENOM; CLU_092286_0_0_2; -.
DR OMA; HPFNACL; -.
DR OrthoDB; 61293at2157; -.
DR UniPathway; UPA00640; UER00698.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030269; F:tetrahydromethanopterin S-methyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01096; MtrC; 1.
DR InterPro; IPR005865; THM_MeTrfase_su_C.
DR Pfam; PF04211; MtrC; 1.
DR PIRSF; PIRSF006530; MtrC; 1.
DR TIGRFAMs; TIGR01148; mtrC; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Methanogenesis; Methyltransferase;
KW One-carbon metabolism; Transferase; Transmembrane; Transmembrane helix.
FT CHAIN 1..267
FT /note="Tetrahydromethanopterin S-methyltransferase subunit
FT C"
FT /id="PRO_0000147521"
FT TRANSMEM 19..39
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01096"
FT TRANSMEM 75..95
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01096"
FT TRANSMEM 97..117
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01096"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01096"
FT TRANSMEM 162..182
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01096"
FT TRANSMEM 198..218
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01096"
FT TRANSMEM 221..241
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01096"
FT CONFLICT 54
FT /note="V -> D (in Ref. 1; CAB41640)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 267 AA; 26805 MW; DF4FE90AB7EEC089 CRC64;
MSAGGAGGEA KGGYPPQTIM ALGIVGGLVG IYLGNFAPPA YSFFGGLGAI CATVWGADAV
RRVASYGLGT GVPSIGMLAL GMGILAALFG LSVGGTAGPI VAIVVAAIIG GVIGALANKV
IGMGIPIMEK AMVEISCAGT LVILGLSVVI AGSFDFASVV QYVVANGYIA LIFIIGGMGI
LHPFNASLGP DEKQDRTLML AVEKGAIALI IAGFASSLHE GLMAAGLNML IGIIIWYVAF
SKHYALIKRD AYAVVGSGML PSSEELQ
