ID   MTRC_METM5              Reviewed;         262 AA.
AC   A4FVW3;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Tetrahydromethanopterin S-methyltransferase subunit C {ECO:0000255|HAMAP-Rule:MF_01096};
DE            EC=2.1.1.86 {ECO:0000255|HAMAP-Rule:MF_01096};
DE   AltName: Full=N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit C {ECO:0000255|HAMAP-Rule:MF_01096};
GN   Name=mtrC {ECO:0000255|HAMAP-Rule:MF_01096}; OrderedLocusNames=MmarC5_0014;
OS   Methanococcus maripaludis (strain C5 / ATCC BAA-1333).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanococcaceae; Methanococcus.
OX   NCBI_TaxID=402880;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C5 / ATCC BAA-1333;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C.,
RA   Detter J.C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Sieprawska-Lupa M., Whitman W.B., Richardson P.;
RT   "Complete sequence of chromosome of Methanococcus maripaludis C5.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Part of a complex that catalyzes the formation of methyl-
CC       coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-
CC       tetrahydromethanopterin. This is an energy-conserving, sodium-ion
CC       translocating step. {ECO:0000255|HAMAP-Rule:MF_01096}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2
CC         Na(+)(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2
CC         Na(+)(out); Xref=Rhea:RHEA:53492, ChEBI:CHEBI:29101,
CC         ChEBI:CHEBI:58103, ChEBI:CHEBI:58116, ChEBI:CHEBI:58286,
CC         ChEBI:CHEBI:58319; EC=2.1.1.86; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01096};
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); methyl-
CC       coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step
CC       2/2. {ECO:0000255|HAMAP-Rule:MF_01096}.
CC   -!- SUBUNIT: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD,
CC       MtrE, MtrF, MtrG and MtrH. {ECO:0000255|HAMAP-Rule:MF_01096}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01096};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01096}.
CC   -!- SIMILARITY: Belongs to the MtrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_01096}.
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DR   EMBL; CP000609; ABO34331.1; -; Genomic_DNA.
DR   RefSeq; WP_011867793.1; NC_009135.1.
DR   AlphaFoldDB; A4FVW3; -.
DR   STRING; 402880.MmarC5_0014; -.
DR   EnsemblBacteria; ABO34331; ABO34331; MmarC5_0014.
DR   GeneID; 4928231; -.
DR   KEGG; mmq:MmarC5_0014; -.
DR   eggNOG; arCOG04868; Archaea.
DR   HOGENOM; CLU_092286_0_0_2; -.
DR   OMA; HPFNACL; -.
DR   OrthoDB; 61293at2157; -.
DR   UniPathway; UPA00640; UER00698.
DR   Proteomes; UP000000253; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030269; F:tetrahydromethanopterin S-methyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01096; MtrC; 1.
DR   InterPro; IPR005865; THM_MeTrfase_su_C.
DR   Pfam; PF04211; MtrC; 1.
DR   PIRSF; PIRSF006530; MtrC; 1.
DR   TIGRFAMs; TIGR01148; mtrC; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Methanogenesis; Methyltransferase;
KW   One-carbon metabolism; Transferase; Transmembrane; Transmembrane helix.
FT   CHAIN           1..262
FT                   /note="Tetrahydromethanopterin S-methyltransferase subunit
FT                   C"
FT                   /id="PRO_1000064939"
FT   TRANSMEM        27..47
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01096"
FT   TRANSMEM        72..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01096"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01096"
FT   TRANSMEM        145..165
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01096"
FT   TRANSMEM        173..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01096"
FT   TRANSMEM        200..220
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01096"
FT   TRANSMEM        222..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01096"
SQ   SEQUENCE   262 AA;  26626 MW;  AF10CDA93568796C CRC64;
     MSHGGGGHAA ELFPEDQVLA FGAVLSLVGI YIAHFFPSLA MLLGGLLAAG ACVAGANTTR
     RVAAYGLGTG VPSIGMVSLG MGTISALAGV LIPSAFGLPV LVTPILAAVI AVVVGFIVGK
     LTQNPVGMKV PIIVSSMTKL SLMGALAILG FCTAFAGGFS ADIIINGAIN NGVIALAFIA
     AGMAILHPFN ACIGPDESHK RTMTLAVACG FMAWLVFAIA KLDIVSTAVA AIFWFIAYGT
     FVKTSLADAC EVKYVPELPK KE