ID   MTRC_METVS              Reviewed;         269 AA.
AC   A6UQK8;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Tetrahydromethanopterin S-methyltransferase subunit C {ECO:0000255|HAMAP-Rule:MF_01096};
DE            EC=2.1.1.86 {ECO:0000255|HAMAP-Rule:MF_01096};
DE   AltName: Full=N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit C {ECO:0000255|HAMAP-Rule:MF_01096};
GN   Name=mtrC {ECO:0000255|HAMAP-Rule:MF_01096}; OrderedLocusNames=Mevan_0875;
OS   Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148
OS   / SB).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanococcaceae; Methanococcus.
OX   NCBI_TaxID=406327;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Anderson I.,
RA   Sieprawska-Lupa M., Whitman W.B., Richardson P.;
RT   "Complete sequence of Methanococcus vannielii SB.";
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Part of a complex that catalyzes the formation of methyl-
CC       coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-
CC       tetrahydromethanopterin. This is an energy-conserving, sodium-ion
CC       translocating step. {ECO:0000255|HAMAP-Rule:MF_01096}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2
CC         Na(+)(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2
CC         Na(+)(out); Xref=Rhea:RHEA:53492, ChEBI:CHEBI:29101,
CC         ChEBI:CHEBI:58103, ChEBI:CHEBI:58116, ChEBI:CHEBI:58286,
CC         ChEBI:CHEBI:58319; EC=2.1.1.86; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01096};
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); methyl-
CC       coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step
CC       2/2. {ECO:0000255|HAMAP-Rule:MF_01096}.
CC   -!- SUBUNIT: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD,
CC       MtrE, MtrF, MtrG and MtrH. {ECO:0000255|HAMAP-Rule:MF_01096}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01096};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01096}.
CC   -!- SIMILARITY: Belongs to the MtrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_01096}.
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DR   EMBL; CP000742; ABR54780.1; -; Genomic_DNA.
DR   RefSeq; WP_011972681.1; NC_009634.1.
DR   AlphaFoldDB; A6UQK8; -.
DR   STRING; 406327.Mevan_0875; -.
DR   EnsemblBacteria; ABR54780; ABR54780; Mevan_0875.
DR   GeneID; 5326189; -.
DR   KEGG; mvn:Mevan_0875; -.
DR   eggNOG; arCOG04868; Archaea.
DR   HOGENOM; CLU_092286_0_0_2; -.
DR   OMA; HPFNACL; -.
DR   OrthoDB; 61293at2157; -.
DR   UniPathway; UPA00640; UER00698.
DR   Proteomes; UP000001107; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030269; F:tetrahydromethanopterin S-methyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01096; MtrC; 1.
DR   InterPro; IPR005865; THM_MeTrfase_su_C.
DR   Pfam; PF04211; MtrC; 1.
DR   PIRSF; PIRSF006530; MtrC; 1.
DR   TIGRFAMs; TIGR01148; mtrC; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Methanogenesis; Methyltransferase;
KW   One-carbon metabolism; Transferase; Transmembrane; Transmembrane helix.
FT   CHAIN           1..269
FT                   /note="Tetrahydromethanopterin S-methyltransferase subunit
FT                   C"
FT                   /id="PRO_1000064941"
FT   TRANSMEM        18..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01096"
FT   TRANSMEM        39..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01096"
FT   TRANSMEM        62..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01096"
FT   TRANSMEM        84..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01096"
FT   TRANSMEM        106..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01096"
FT   TRANSMEM        152..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01096"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01096"
FT   TRANSMEM        222..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01096"
SQ   SEQUENCE   269 AA;  27343 MW;  622CA6582F91231E CRC64;
     MSHGGGGHAA ELFPENQVLV IGAVLSLIGM YIAHFVPSLA MLLGGLLAAG ACVAGANTTR
     RVAAYGLGTG VPSIGMVSLG MGTISALAGV LIPSVLAGSV ALPFDLVLAT PIIAAVVAII
     VGFIVGKLTQ NPVGMKVPII VSSMTKLSLM GALAILGFCT AFAGGFSADL IINGAINNGI
     IALAFIAAGM SILHPFNACI GPNESHKRTI TLATACGLMA WLVFSIAKLD IVSILVAAVF
     WIYTYGSFVS MSLADACEVK YVPELPKKE