MTRD_METMP
ID MTRD_METMP Reviewed; 235 AA.
AC Q6LWZ3;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Tetrahydromethanopterin S-methyltransferase subunit D {ECO:0000255|HAMAP-Rule:MF_01097};
DE EC=2.1.1.86 {ECO:0000255|HAMAP-Rule:MF_01097};
DE AltName: Full=N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit D {ECO:0000255|HAMAP-Rule:MF_01097};
GN Name=mtrD {ECO:0000255|HAMAP-Rule:MF_01097}; OrderedLocusNames=MMP1561;
OS Methanococcus maripaludis (strain S2 / LL).
OC Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC Methanococcaceae; Methanococcus.
OX NCBI_TaxID=267377;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S2 / LL;
RX PubMed=15466049; DOI=10.1128/jb.186.20.6956-6969.2004;
RA Hendrickson E.L., Kaul R., Zhou Y., Bovee D., Chapman P., Chung J.,
RA Conway de Macario E., Dodsworth J.A., Gillett W., Graham D.E., Hackett M.,
RA Haydock A.K., Kang A., Land M.L., Levy R., Lie T.J., Major T.A.,
RA Moore B.C., Porat I., Palmeiri A., Rouse G., Saenphimmachak C., Soell D.,
RA Van Dien S., Wang T., Whitman W.B., Xia Q., Zhang Y., Larimer F.W.,
RA Olson M.V., Leigh J.A.;
RT "Complete genome sequence of the genetically tractable hydrogenotrophic
RT methanogen Methanococcus maripaludis.";
RL J. Bacteriol. 186:6956-6969(2004).
CC -!- FUNCTION: Part of a complex that catalyzes the formation of methyl-
CC coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-
CC tetrahydromethanopterin. This is an energy-conserving, sodium-ion
CC translocating step. {ECO:0000255|HAMAP-Rule:MF_01097}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2
CC Na(+)(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2
CC Na(+)(out); Xref=Rhea:RHEA:53492, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:58103, ChEBI:CHEBI:58116, ChEBI:CHEBI:58286,
CC ChEBI:CHEBI:58319; EC=2.1.1.86; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_01097};
CC -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); methyl-
CC coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step
CC 2/2. {ECO:0000255|HAMAP-Rule:MF_01097}.
CC -!- SUBUNIT: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD,
CC MtrE, MtrF, MtrG and MtrH. {ECO:0000255|HAMAP-Rule:MF_01097}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01097};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01097}.
CC -!- SIMILARITY: Belongs to the MtrD family. {ECO:0000255|HAMAP-
CC Rule:MF_01097}.
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DR EMBL; BX950229; CAF31117.1; -; Genomic_DNA.
DR RefSeq; WP_011171505.1; NC_005791.1.
DR AlphaFoldDB; Q6LWZ3; -.
DR STRING; 267377.MMP1561; -.
DR EnsemblBacteria; CAF31117; CAF31117; MMP1561.
DR GeneID; 41280202; -.
DR KEGG; mmp:MMP1561; -.
DR PATRIC; fig|267377.15.peg.1599; -.
DR eggNOG; arCOG04869; Archaea.
DR HOGENOM; CLU_1109510_0_0_2; -.
DR OMA; HDPKFKR; -.
DR OrthoDB; 95538at2157; -.
DR BioCyc; MMAR267377:MMP_RS08035-MON; -.
DR UniPathway; UPA00640; UER00698.
DR Proteomes; UP000000590; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0012506; C:vesicle membrane; IEA:InterPro.
DR GO; GO:0030269; F:tetrahydromethanopterin S-methyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0006814; P:sodium ion transport; IEA:InterPro.
DR HAMAP; MF_01097; MtrD; 1.
DR InterPro; IPR005779; MeTrfase_D.
DR Pfam; PF04207; MtrD; 1.
DR PIRSF; PIRSF016552; MtrD; 1.
DR TIGRFAMs; TIGR01112; mtrD; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Methanogenesis; Methyltransferase;
KW One-carbon metabolism; Reference proteome; Transferase; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..235
FT /note="Tetrahydromethanopterin S-methyltransferase subunit
FT D"
FT /id="PRO_0000147533"
FT TRANSMEM 15..37
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01097"
FT TRANSMEM 49..71
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01097"
FT TRANSMEM 86..108
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01097"
FT TRANSMEM 143..165
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01097"
FT TRANSMEM 169..191
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01097"
FT TRANSMEM 212..234
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01097"
SQ SEQUENCE 235 AA; 23229 MW; A5E9A08B810C1961 CRC64;
MDATSFILPL AEITIAGAII NASVHFVPVG GAPAAMATST GVGTGTTQLA AGAGFTGLLA
AAAMASQAGV SLSNPVHMLL IMLSGAVGAM IMLGLTMLIG QIIYVYGIGI VPAADKCEKD
PITGDIQKPY ITPGTTGHGI PTVCFVSGTI GAALGGLGGA LAYIALQQLG FAAAIAGVLA
VGFFFMNAVL ASYNIGGTIE GFHDPKFKKM PNGVIASFVS SLIAGAVLIG MAMGL
