ID   MTRE_METFE              Reviewed;         257 AA.
AC   Q49176;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Tetrahydromethanopterin S-methyltransferase subunit E;
DE            EC=2.1.1.86;
DE   AltName: Full=N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit E;
GN   Name=mtrE;
OS   Methanothermus fervidus.
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanothermaceae; Methanothermus.
OX   NCBI_TaxID=2180;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3170483; DOI=10.1128/jb.170.10.4718-4726.1988;
RA   Weil C.F., Cram D.S., Sherf B.A., Reeve J.N.;
RT   "Structure and comparative analysis of the genes encoding component C of
RT   methyl coenzyme M reductase in the extremely thermophilic archaebacterium
RT   Methanothermus fervidus.";
RL   J. Bacteriol. 170:4718-4726(1988).
CC   -!- FUNCTION: Part of a complex that catalyzes the formation of methyl-
CC       coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-
CC       tetrahydromethanopterin. This is an energy-conserving, sodium-ion
CC       translocating step. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2
CC         Na(+)(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2
CC         Na(+)(out); Xref=Rhea:RHEA:53492, ChEBI:CHEBI:29101,
CC         ChEBI:CHEBI:58103, ChEBI:CHEBI:58116, ChEBI:CHEBI:58286,
CC         ChEBI:CHEBI:58319; EC=2.1.1.86;
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); methyl-
CC       coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step
CC       2/2.
CC   -!- SUBUNIT: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD,
CC       MtrE, MtrF, MtrG and MtrH. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the MtrE family. {ECO:0000305}.
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DR   EMBL; J03375; AAA72198.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q49176; -.
DR   UniPathway; UPA00640; UER00698.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0012506; C:vesicle membrane; IEA:InterPro.
DR   GO; GO:0030269; F:tetrahydromethanopterin S-methyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006814; P:sodium ion transport; IEA:InterPro.
DR   HAMAP; MF_01098; MtrE; 1.
DR   InterPro; IPR005780; MeTrfase_E.
DR   Pfam; PF04206; MtrE; 1.
DR   PIRSF; PIRSF016509; MtrE; 1.
DR   TIGRFAMs; TIGR01113; mtrE; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Methanogenesis; Methyltransferase;
KW   One-carbon metabolism; Transferase; Transmembrane; Transmembrane helix.
FT   CHAIN           1..257
FT                   /note="Tetrahydromethanopterin S-methyltransferase subunit
FT                   E"
FT                   /id="PRO_0000147538"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        62..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        132..152
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        164..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        229..249
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   257 AA;  26896 MW;  389DEF5E7BE36B15 CRC64;
     MDPAVASLGI LALTTASAII GQTIEDVETN IGSQSNPNSQ VQLAPQMGNL HRFFNKAIAG
     EPFAYCTFCG VSGAITVATL YLHLPAVIAL AIGAAITTLI WLAYSTTAYL GRVSGSATFN
     QPVFLDMLTE NLGPIAGHAF IVFFCMTGVA YLMTLPVKGF AHPFPIPVIG MIWGMTIGAI
     GSAVGDVYYG AEAEFVHKKF GGGIPVASHG DITRKGVLGA RSPMEVGNFT VKYGSPITGM
     AFGLIVLSIT RGVYNIE