MTRE_METMP
ID MTRE_METMP Reviewed; 299 AA.
AC Q6LWZ4;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Tetrahydromethanopterin S-methyltransferase subunit E {ECO:0000255|HAMAP-Rule:MF_01098};
DE EC=2.1.1.86 {ECO:0000255|HAMAP-Rule:MF_01098};
DE AltName: Full=N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit E {ECO:0000255|HAMAP-Rule:MF_01098};
GN Name=mtrE {ECO:0000255|HAMAP-Rule:MF_01098}; OrderedLocusNames=MMP1560;
OS Methanococcus maripaludis (strain S2 / LL).
OC Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC Methanococcaceae; Methanococcus.
OX NCBI_TaxID=267377;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S2 / LL;
RX PubMed=15466049; DOI=10.1128/jb.186.20.6956-6969.2004;
RA Hendrickson E.L., Kaul R., Zhou Y., Bovee D., Chapman P., Chung J.,
RA Conway de Macario E., Dodsworth J.A., Gillett W., Graham D.E., Hackett M.,
RA Haydock A.K., Kang A., Land M.L., Levy R., Lie T.J., Major T.A.,
RA Moore B.C., Porat I., Palmeiri A., Rouse G., Saenphimmachak C., Soell D.,
RA Van Dien S., Wang T., Whitman W.B., Xia Q., Zhang Y., Larimer F.W.,
RA Olson M.V., Leigh J.A.;
RT "Complete genome sequence of the genetically tractable hydrogenotrophic
RT methanogen Methanococcus maripaludis.";
RL J. Bacteriol. 186:6956-6969(2004).
CC -!- FUNCTION: Part of a complex that catalyzes the formation of methyl-
CC coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-
CC tetrahydromethanopterin. This is an energy-conserving, sodium-ion
CC translocating step. {ECO:0000255|HAMAP-Rule:MF_01098}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2
CC Na(+)(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2
CC Na(+)(out); Xref=Rhea:RHEA:53492, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:58103, ChEBI:CHEBI:58116, ChEBI:CHEBI:58286,
CC ChEBI:CHEBI:58319; EC=2.1.1.86; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_01098};
CC -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); methyl-
CC coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step
CC 2/2. {ECO:0000255|HAMAP-Rule:MF_01098}.
CC -!- SUBUNIT: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD,
CC MtrE, MtrF, MtrG and MtrH. {ECO:0000255|HAMAP-Rule:MF_01098}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01098};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01098}.
CC -!- SIMILARITY: Belongs to the MtrE family. {ECO:0000255|HAMAP-
CC Rule:MF_01098}.
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DR EMBL; BX950229; CAF31116.1; -; Genomic_DNA.
DR RefSeq; WP_011171504.1; NC_005791.1.
DR AlphaFoldDB; Q6LWZ4; -.
DR STRING; 267377.MMP1560; -.
DR EnsemblBacteria; CAF31116; CAF31116; MMP1560.
DR GeneID; 36102362; -.
DR KEGG; mmp:MMP1560; -.
DR PATRIC; fig|267377.15.peg.1598; -.
DR eggNOG; arCOG04870; Archaea.
DR HOGENOM; CLU_958513_0_0_2; -.
DR OMA; QMGNIHR; -.
DR OrthoDB; 50292at2157; -.
DR BioCyc; MMAR267377:MMP_RS08030-MON; -.
DR UniPathway; UPA00640; UER00698.
DR Proteomes; UP000000590; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0012506; C:vesicle membrane; IEA:InterPro.
DR GO; GO:0030269; F:tetrahydromethanopterin S-methyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0006814; P:sodium ion transport; IEA:InterPro.
DR HAMAP; MF_01098; MtrE; 1.
DR InterPro; IPR005780; MeTrfase_E.
DR Pfam; PF04206; MtrE; 1.
DR PIRSF; PIRSF016509; MtrE; 1.
DR TIGRFAMs; TIGR01113; mtrE; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Methanogenesis; Methyltransferase;
KW One-carbon metabolism; Reference proteome; Transferase; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..299
FT /note="Tetrahydromethanopterin S-methyltransferase subunit
FT E"
FT /id="PRO_0000147542"
FT TRANSMEM 57..79
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01098"
FT TRANSMEM 89..111
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01098"
FT TRANSMEM 132..154
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01098"
FT TRANSMEM 164..183
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01098"
FT TRANSMEM 227..246
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01098"
FT TRANSMEM 261..283
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01098"
SQ SEQUENCE 299 AA; 31080 MW; 491398A966D67BC4 CRC64;
MDPTLISLGA LALAGAAATV SGCAEDLESD VGSQSNPNSQ VQLGPQMGNI HRYFNKAISG
EPVSYGLYVA VAGTIAWALI NAGLNVVLAI IVGAGVAAIV HGAYSVSAFL GRTVGQSKKF
GQPVYMDVLT SHIGPIVGHG FIAVFTMTLA AYLATTALGN PFPLPLVSLI FGITVGAIGS
STGDVHYGAE REYQKYPFGG GIPVANQGDI DIYAEYGVRN GLDSSYFCSR FGGPLTGLCF
GLIIFLDGWR SILGNIIGGD LVTKTSIALL VGLLVVAVAA VINRKLEVYA RNKYGPYRN
