MTRF2_DANRE
ID MTRF2_DANRE Reviewed; 336 AA.
AC Q08BD8;
DT 13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=Mitochondrial fission regulator 2;
GN Name=mtfr2; Synonyms=fam54a; ORFNames=zgc:153910;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May play a role in mitochondrial aerobic respiration. Can
CC also promote mitochondrial fission (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MTFR1 family. {ECO:0000305}.
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DR EMBL; BX927210; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC124770; AAI24771.1; -; mRNA.
DR RefSeq; NP_001070753.1; NM_001077285.1.
DR AlphaFoldDB; Q08BD8; -.
DR SMR; Q08BD8; -.
DR STRING; 7955.ENSDARP00000079489; -.
DR PaxDb; Q08BD8; -.
DR Ensembl; ENSDART00000085054; ENSDARP00000079489; ENSDARG00000060394.
DR GeneID; 768141; -.
DR KEGG; dre:768141; -.
DR CTD; 113115; -.
DR ZFIN; ZDB-GENE-061013-398; mtfr2.
DR eggNOG; ENOG502QUU8; Eukaryota.
DR GeneTree; ENSGT00950000183215; -.
DR HOGENOM; CLU_059135_0_0_1; -.
DR InParanoid; Q08BD8; -.
DR OMA; SHNHFVI; -.
DR OrthoDB; 1485791at2759; -.
DR PhylomeDB; Q08BD8; -.
DR TreeFam; TF331404; -.
DR PRO; PR:Q08BD8; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 23.
DR Bgee; ENSDARG00000060394; Expressed in early embryo and 41 other tissues.
DR ExpressionAtlas; Q08BD8; baseline and differential.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0009060; P:aerobic respiration; IBA:GO_Central.
DR GO; GO:0000266; P:mitochondrial fission; IBA:GO_Central.
DR InterPro; IPR007972; Mtfr1.
DR PANTHER; PTHR14215; PTHR14215; 1.
DR Pfam; PF05308; Mito_fiss_reg; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Mitochondrion; Reference proteome.
FT CHAIN 1..336
FT /note="Mitochondrial fission regulator 2"
FT /id="PRO_0000417560"
FT REGION 296..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 139..166
FT /evidence="ECO:0000255"
FT COMPBIAS 309..327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 336 AA; 36697 MW; 57C9AB506430E0C1 CRC64;
MSLLEDIVDL LKCVLEYFGV PPDMLVPVWE STHCGQYRSL VRMIGTNLPL SPYPRLRFQI
PLQTFNKHSH IDVSVDSPAI PTLADVLWLV EDEGDSHTKF RNAVPLRKKC VPHGYETPSL
GSVSVKAQRG GGVLAQSTQP DALLKISALE EELQRLRAQI ATIITAPAGP VVSPTDPGTP
CSAPKPAPVL TSTPVCPPPP PPPPPPAMPT RTEVSMSEMI QQRQAAKKET LAQCGPSLTT
APSMLEVLRD LNQVKLRSVE RSPGGTPIRR RRSKGVACSS DPAALIAEAL KRKFAHRQRD
DSFGKENHSA EPSPFSSPDT PRIFQHTRRS QGRIHL
