ID   MTRF_METKA              Reviewed;          75 AA.
AC   Q8TVA7;
DT   15-DEC-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Tetrahydromethanopterin S-methyltransferase subunit F {ECO:0000255|HAMAP-Rule:MF_01099};
DE            EC=2.1.1.86 {ECO:0000255|HAMAP-Rule:MF_01099};
DE   AltName: Full=N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit F {ECO:0000255|HAMAP-Rule:MF_01099};
GN   Name=mtrF {ECO:0000255|HAMAP-Rule:MF_01099}; OrderedLocusNames=MK1485;
OS   Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938).
OC   Archaea; Euryarchaeota; Methanopyri; Methanopyrales; Methanopyraceae;
OC   Methanopyrus.
OX   NCBI_TaxID=190192;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AV19 / DSM 6324 / JCM 9639 / NBRC 100938;
RX   PubMed=11930014; DOI=10.1073/pnas.032671499;
RA   Slesarev A.I., Mezhevaya K.V., Makarova K.S., Polushin N.N.,
RA   Shcherbinina O.V., Shakhova V.V., Belova G.I., Aravind L., Natale D.A.,
RA   Rogozin I.B., Tatusov R.L., Wolf Y.I., Stetter K.O., Malykh A.G.,
RA   Koonin E.V., Kozyavkin S.A.;
RT   "The complete genome of hyperthermophile Methanopyrus kandleri AV19 and
RT   monophyly of archaeal methanogens.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:4644-4649(2002).
CC   -!- FUNCTION: Part of a complex that catalyzes the formation of methyl-
CC       coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-
CC       tetrahydromethanopterin. This is an energy-conserving, sodium-ion
CC       translocating step. {ECO:0000255|HAMAP-Rule:MF_01099}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2
CC         Na(+)(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2
CC         Na(+)(out); Xref=Rhea:RHEA:53492, ChEBI:CHEBI:29101,
CC         ChEBI:CHEBI:58103, ChEBI:CHEBI:58116, ChEBI:CHEBI:58286,
CC         ChEBI:CHEBI:58319; EC=2.1.1.86; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01099};
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); methyl-
CC       coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step
CC       2/2. {ECO:0000255|HAMAP-Rule:MF_01099}.
CC   -!- SUBUNIT: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD,
CC       MtrE, MtrF, MtrG and MtrH. {ECO:0000255|HAMAP-Rule:MF_01099}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01099};
CC       Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01099}.
CC   -!- MISCELLANEOUS: Unlike other orthologs, MtrF from M.kandleri is not
CC       located in the mtr operon.
CC   -!- SIMILARITY: Belongs to the MtrF family. {ECO:0000255|HAMAP-
CC       Rule:MF_01099}.
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DR   EMBL; AE009439; AAM02698.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8TVA7; -.
DR   SMR; Q8TVA7; -.
DR   EnsemblBacteria; AAM02698; AAM02698; MK1485.
DR   KEGG; mka:MK1485; -.
DR   HOGENOM; CLU_2662350_0_0_2; -.
DR   UniPathway; UPA00640; UER00698.
DR   Proteomes; UP000001826; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030269; F:tetrahydromethanopterin S-methyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01099; MtrF; 1.
DR   InterPro; IPR011307; MeTrfase_F.
DR   InterPro; IPR013347; MeTrfase_F_su.
DR   Pfam; PF09472; MtrF; 1.
DR   PIRSF; PIRSF006523; MtrF; 1.
DR   TIGRFAMs; TIGR02507; MtrF; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Methanogenesis; Methyltransferase;
KW   One-carbon metabolism; Reference proteome; Transferase; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..75
FT                   /note="Tetrahydromethanopterin S-methyltransferase subunit
FT                   F"
FT                   /id="PRO_0000147549"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01099"
SQ   SEQUENCE   75 AA;  8130 MW;  0186C402CCFCEF28 CRC64;
     MAEEGSELKE VIIGAPAMAD TDRADTYVND VRDSSQFFGR DARLYFGLNV NRFAGLACGM
     VFAGVLLVPL LLLAF