MTRG_METJA
ID MTRG_METJA Reviewed; 84 AA.
AC Q58263;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 25-MAY-2022, entry version 112.
DE RecName: Full=Tetrahydromethanopterin S-methyltransferase subunit G {ECO:0000255|HAMAP-Rule:MF_01500};
DE EC=2.1.1.86 {ECO:0000255|HAMAP-Rule:MF_01500};
DE AltName: Full=N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit G {ECO:0000255|HAMAP-Rule:MF_01500};
GN Name=mtrG {ECO:0000255|HAMAP-Rule:MF_01500}; OrderedLocusNames=MJ0853;
OS Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS 10045 / NBRC 100440) (Methanococcus jannaschii).
OC Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC Methanocaldococcaceae; Methanocaldococcus.
OX NCBI_TaxID=243232;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT jannaschii.";
RL Science 273:1058-1073(1996).
CC -!- FUNCTION: Part of a complex that catalyzes the formation of methyl-
CC coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-
CC tetrahydromethanopterin. This is an energy-conserving, sodium-ion
CC translocating step. {ECO:0000255|HAMAP-Rule:MF_01500}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2
CC Na(+)(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2
CC Na(+)(out); Xref=Rhea:RHEA:53492, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:58103, ChEBI:CHEBI:58116, ChEBI:CHEBI:58286,
CC ChEBI:CHEBI:58319; EC=2.1.1.86; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_01500};
CC -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); methyl-
CC coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step
CC 2/2. {ECO:0000255|HAMAP-Rule:MF_01500}.
CC -!- SUBUNIT: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD,
CC MtrE, MtrF, MtrG and MtrH. {ECO:0000255|HAMAP-Rule:MF_01500}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01500};
CC Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01500}.
CC -!- SIMILARITY: Belongs to the MtrG family. {ECO:0000255|HAMAP-
CC Rule:MF_01500}.
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DR EMBL; L77117; AAB98858.1; -; Genomic_DNA.
DR PIR; E64406; E64406.
DR RefSeq; WP_010870367.1; NC_000909.1.
DR AlphaFoldDB; Q58263; -.
DR SMR; Q58263; -.
DR STRING; 243232.MJ_0853; -.
DR EnsemblBacteria; AAB98858; AAB98858; MJ_0853.
DR GeneID; 1451741; -.
DR KEGG; mja:MJ_0853; -.
DR eggNOG; arCOG03380; Archaea.
DR HOGENOM; CLU_191926_0_0_2; -.
DR InParanoid; Q58263; -.
DR OMA; PQVIMDP; -.
DR OrthoDB; 130315at2157; -.
DR PhylomeDB; Q58263; -.
DR UniPathway; UPA00640; UER00698.
DR Proteomes; UP000000805; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030269; F:tetrahydromethanopterin S-methyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01500; MtrG; 1.
DR InterPro; IPR005866; THM_MeTrfase_su_G.
DR Pfam; PF04210; MtrG; 1.
DR PIRSF; PIRSF006500; MtrG; 1.
DR TIGRFAMs; TIGR01149; mtrG; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Methanogenesis; Methyltransferase;
KW One-carbon metabolism; Reference proteome; Transferase; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..84
FT /note="Tetrahydromethanopterin S-methyltransferase subunit
FT G"
FT /id="PRO_0000147555"
FT TRANSMEM 50..70
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01500"
SQ SEQUENCE 84 AA; 9449 MW; 4802F872BAD32A2E CRC64;
MSEDEKLPQV IMDPADYEAL KKRLDELEKK VENTNAELFQ LAGKKVGRDI GILYGLVIGI
ILSYILPALI KIIQILSLKV LVQQ
