ID   MTRG_METKA              Reviewed;          74 AA.
AC   O32868;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 111.
DE   RecName: Full=Tetrahydromethanopterin S-methyltransferase subunit G {ECO:0000255|HAMAP-Rule:MF_01500};
DE            EC=2.1.1.86 {ECO:0000255|HAMAP-Rule:MF_01500};
DE   AltName: Full=N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit G {ECO:0000255|HAMAP-Rule:MF_01500};
GN   Name=mtrG {ECO:0000255|HAMAP-Rule:MF_01500}; OrderedLocusNames=MK0661;
OS   Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938).
OC   Archaea; Euryarchaeota; Methanopyri; Methanopyrales; Methanopyraceae;
OC   Methanopyrus.
OX   NCBI_TaxID=190192;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9461302; DOI=10.1111/j.1432-1033.1997.00783.x;
RA   Harms U., Thauer R.K.;
RT   "Identification of the active site histidine in the corrinoid protein MtrA
RT   of the energy-conserving methyltransferase complex from Methanobacterium
RT   thermoautotrophicum.";
RL   Eur. J. Biochem. 250:783-788(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AV19 / DSM 6324 / JCM 9639 / NBRC 100938;
RX   PubMed=11930014; DOI=10.1073/pnas.032671499;
RA   Slesarev A.I., Mezhevaya K.V., Makarova K.S., Polushin N.N.,
RA   Shcherbinina O.V., Shakhova V.V., Belova G.I., Aravind L., Natale D.A.,
RA   Rogozin I.B., Tatusov R.L., Wolf Y.I., Stetter K.O., Malykh A.G.,
RA   Koonin E.V., Kozyavkin S.A.;
RT   "The complete genome of hyperthermophile Methanopyrus kandleri AV19 and
RT   monophyly of archaeal methanogens.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:4644-4649(2002).
CC   -!- FUNCTION: Part of a complex that catalyzes the formation of methyl-
CC       coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-
CC       tetrahydromethanopterin. This is an energy-conserving, sodium-ion
CC       translocating step. {ECO:0000255|HAMAP-Rule:MF_01500}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2
CC         Na(+)(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2
CC         Na(+)(out); Xref=Rhea:RHEA:53492, ChEBI:CHEBI:29101,
CC         ChEBI:CHEBI:58103, ChEBI:CHEBI:58116, ChEBI:CHEBI:58286,
CC         ChEBI:CHEBI:58319; EC=2.1.1.86; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01500};
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); methyl-
CC       coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step
CC       2/2. {ECO:0000255|HAMAP-Rule:MF_01500}.
CC   -!- SUBUNIT: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD,
CC       MtrE, MtrF, MtrG and MtrH. {ECO:0000255|HAMAP-Rule:MF_01500}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01500};
CC       Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01500}.
CC   -!- SIMILARITY: Belongs to the MtrG family. {ECO:0000255|HAMAP-
CC       Rule:MF_01500}.
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DR   EMBL; Y14428; CAA74772.1; -; Genomic_DNA.
DR   EMBL; AE009439; AAM01876.1; -; Genomic_DNA.
DR   AlphaFoldDB; O32868; -.
DR   SMR; O32868; -.
DR   STRING; 190192.MK0661; -.
DR   EnsemblBacteria; AAM01876; AAM01876; MK0661.
DR   KEGG; mka:MK0661; -.
DR   HOGENOM; CLU_191926_0_0_2; -.
DR   OMA; PQVIMDP; -.
DR   UniPathway; UPA00640; UER00698.
DR   Proteomes; UP000001826; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030269; F:tetrahydromethanopterin S-methyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01500; MtrG; 1.
DR   InterPro; IPR005866; THM_MeTrfase_su_G.
DR   Pfam; PF04210; MtrG; 1.
DR   PIRSF; PIRSF006500; MtrG; 1.
DR   TIGRFAMs; TIGR01149; mtrG; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Methanogenesis; Methyltransferase;
KW   One-carbon metabolism; Reference proteome; Transferase; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..74
FT                   /note="Tetrahydromethanopterin S-methyltransferase subunit
FT                   G"
FT                   /id="PRO_0000147556"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01500"
SQ   SEQUENCE   74 AA;  8674 MW;  3ADEDC322E3F664F CRC64;
     MAEEESVPKM VAPEDDIREI HSRLDEIERR LDFVWGEVYQ RFGKRIGRDI GILYGLVIGL
     YLCMLYILLG VAFR