ID   MTRG_METTH              Reviewed;          86 AA.
AC   O27225;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   25-MAY-2022, entry version 129.
DE   RecName: Full=Tetrahydromethanopterin S-methyltransferase subunit G {ECO:0000255|HAMAP-Rule:MF_01500};
DE            EC=2.1.1.86 {ECO:0000255|HAMAP-Rule:MF_01500};
DE   AltName: Full=N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit G {ECO:0000255|HAMAP-Rule:MF_01500};
GN   Name=mtrG {ECO:0000255|HAMAP-Rule:MF_01500}; OrderedLocusNames=MTH_1157;
OS   Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS   10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=187420;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX   PubMed=9371463; DOI=10.1128/jb.179.22.7135-7155.1997;
RA   Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA   Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA   Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA   Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA   Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA   Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J.,
RA   Reeve J.N.;
RT   "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT   functional analysis and comparative genomics.";
RL   J. Bacteriol. 179:7135-7155(1997).
CC   -!- FUNCTION: Part of a complex that catalyzes the formation of methyl-
CC       coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-
CC       tetrahydromethanopterin. This is an energy-conserving, sodium-ion
CC       translocating step. {ECO:0000255|HAMAP-Rule:MF_01500}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2
CC         Na(+)(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2
CC         Na(+)(out); Xref=Rhea:RHEA:53492, ChEBI:CHEBI:29101,
CC         ChEBI:CHEBI:58103, ChEBI:CHEBI:58116, ChEBI:CHEBI:58286,
CC         ChEBI:CHEBI:58319; EC=2.1.1.86; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01500};
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); methyl-
CC       coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step
CC       2/2. {ECO:0000255|HAMAP-Rule:MF_01500}.
CC   -!- SUBUNIT: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD,
CC       MtrE, MtrF, MtrG and MtrH. {ECO:0000255|HAMAP-Rule:MF_01500}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01500};
CC       Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01500}.
CC   -!- SIMILARITY: Belongs to the MtrG family. {ECO:0000255|HAMAP-
CC       Rule:MF_01500}.
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DR   EMBL; AE000666; AAB85646.1; -; Genomic_DNA.
DR   PIR; B69021; B69021.
DR   RefSeq; WP_010876781.1; NC_000916.1.
DR   AlphaFoldDB; O27225; -.
DR   SMR; O27225; -.
DR   IntAct; O27225; 2.
DR   STRING; 187420.MTH_1157; -.
DR   EnsemblBacteria; AAB85646; AAB85646; MTH_1157.
DR   GeneID; 1471565; -.
DR   KEGG; mth:MTH_1157; -.
DR   PATRIC; fig|187420.15.peg.1134; -.
DR   HOGENOM; CLU_191926_0_0_2; -.
DR   OMA; PQVIMDP; -.
DR   UniPathway; UPA00640; UER00698.
DR   Proteomes; UP000005223; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030269; F:tetrahydromethanopterin S-methyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01500; MtrG; 1.
DR   InterPro; IPR005866; THM_MeTrfase_su_G.
DR   Pfam; PF04210; MtrG; 1.
DR   PIRSF; PIRSF006500; MtrG; 1.
DR   TIGRFAMs; TIGR01149; mtrG; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Methanogenesis; Methyltransferase;
KW   One-carbon metabolism; Reference proteome; Transferase; Transmembrane;
KW   Transmembrane helix.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..86
FT                   /note="Tetrahydromethanopterin S-methyltransferase subunit
FT                   G"
FT                   /id="PRO_0000147559"
FT   TRANSMEM        52..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01500"
SQ   SEQUENCE   86 AA;  9510 MW;  A426DE19DE2A6530 CRC64;
     MSEEDKTTIP RVLVSADEFN KANERLDDIE EKVEFTVGEY SQRIGQQIGR DIGILYGIVI
     GLIILAVTNI LFAGLLKGLL KSLFGL