ID   MTRH_META3              Reviewed;         319 AA.
AC   A6UWI0;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Tetrahydromethanopterin S-methyltransferase subunit H {ECO:0000255|HAMAP-Rule:MF_01501};
DE            EC=2.1.1.86 {ECO:0000255|HAMAP-Rule:MF_01501};
DE   AltName: Full=N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit H {ECO:0000255|HAMAP-Rule:MF_01501};
GN   Name=mtrH {ECO:0000255|HAMAP-Rule:MF_01501}; OrderedLocusNames=Maeo_1276;
OS   Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 /
OS   Nankai-3).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanococcaceae; Methanococcus.
OX   NCBI_TaxID=419665;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A.,
RA   Sieprawska-Lupa M., Whitman W.B., Richardson P.;
RT   "Complete sequence of Methanococcus aeolicus Nankai-3.";
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Part of a complex that catalyzes the formation of methyl-
CC       coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-
CC       tetrahydromethanopterin. This is an energy-conserving, sodium-ion
CC       translocating step. MtrH catalyzes the transfer of the methyl group
CC       from methyl-tetrahydromethanopterin to the corrinoid prosthetic group
CC       of MtrA. {ECO:0000255|HAMAP-Rule:MF_01501}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2
CC         Na(+)(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2
CC         Na(+)(out); Xref=Rhea:RHEA:53492, ChEBI:CHEBI:29101,
CC         ChEBI:CHEBI:58103, ChEBI:CHEBI:58116, ChEBI:CHEBI:58286,
CC         ChEBI:CHEBI:58319; EC=2.1.1.86; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01501};
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); methyl-
CC       coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step
CC       2/2. {ECO:0000255|HAMAP-Rule:MF_01501}.
CC   -!- SUBUNIT: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD,
CC       MtrE, MtrF, MtrG and MtrH. {ECO:0000255|HAMAP-Rule:MF_01501}.
CC   -!- SIMILARITY: Belongs to the MtrH family. {ECO:0000255|HAMAP-
CC       Rule:MF_01501}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000743; ABR56852.1; -; Genomic_DNA.
DR   RefSeq; WP_011973984.1; NC_009635.1.
DR   AlphaFoldDB; A6UWI0; -.
DR   SMR; A6UWI0; -.
DR   STRING; 419665.Maeo_1276; -.
DR   EnsemblBacteria; ABR56852; ABR56852; Maeo_1276.
DR   GeneID; 5326934; -.
DR   KEGG; mae:Maeo_1276; -.
DR   eggNOG; arCOG04336; Archaea.
DR   HOGENOM; CLU_048697_0_0_2; -.
DR   OMA; YARHKIV; -.
DR   OrthoDB; 86442at2157; -.
DR   UniPathway; UPA00640; UER00698.
DR   Proteomes; UP000001106; Chromosome.
DR   GO; GO:0030269; F:tetrahydromethanopterin S-methyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.20.20.20; -; 1.
DR   HAMAP; MF_01501; MtrH; 1.
DR   InterPro; IPR011005; Dihydropteroate_synth-like.
DR   InterPro; IPR023467; MeTrfase_MtrH/MtxH.
DR   InterPro; IPR028342; MtrH.
DR   Pfam; PF02007; MtrH; 1.
DR   PIRSF; PIRSF500206; MtrH; 1.
DR   PIRSF; PIRSF004960; MtrH_MtxH; 1.
DR   SUPFAM; SSF51717; SSF51717; 1.
DR   TIGRFAMs; TIGR01114; mtrH; 1.
PE   3: Inferred from homology;
KW   Methanogenesis; Methyltransferase; One-carbon metabolism;
KW   Reference proteome; Transferase.
FT   CHAIN           1..319
FT                   /note="Tetrahydromethanopterin S-methyltransferase subunit
FT                   H"
FT                   /id="PRO_1000024471"
SQ   SEQUENCE   319 AA;  34179 MW;  EF334842077FED02 CRC64;
     MFKFDKEQMV IEIAGRKFGG QPGEYPTGLS GTIFYARHKI VEDEIKGIFD KSAAEALINK
     QAEMEDTTGN PALVQVFGGN PEALTKYIDF VAEVWDGPML LDSTSGEARM AAATRATEAG
     YANQCIYNSI NVSIDEAEFQ NLVESDIEAS IVLCFDPMDP SVEGKLNVLL DGGKTTDTGM
     LDLAEKAGIK YPLIDVACTP LGSGAGQSVR ASFAVKAKLG LPVGSGIHNI PSAWDWLRDF
     RKGLREAGQT QLAKDVHHVC DIGANIVQTM GSGDFVLYGP IDNAELAFPA VAMTDMVIAE
     TAKDMGTVPV DTHPINKLL