ID   MTRH_METJA              Reviewed;         319 AA.
AC   Q58264;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 2.
DT   25-MAY-2022, entry version 121.
DE   RecName: Full=Tetrahydromethanopterin S-methyltransferase subunit H {ECO:0000255|HAMAP-Rule:MF_01501};
DE            EC=2.1.1.86 {ECO:0000255|HAMAP-Rule:MF_01501};
DE   AltName: Full=N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit H {ECO:0000255|HAMAP-Rule:MF_01501};
GN   Name=mtrH {ECO:0000255|HAMAP-Rule:MF_01501}; OrderedLocusNames=MJ0854;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- FUNCTION: Part of a complex that catalyzes the formation of methyl-
CC       coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-
CC       tetrahydromethanopterin. This is an energy-conserving, sodium-ion
CC       translocating step. MtrH catalyzes the transfer of the methyl group
CC       from methyl-tetrahydromethanopterin to the corrinoid prosthetic group
CC       of MtrA. {ECO:0000255|HAMAP-Rule:MF_01501}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2
CC         Na(+)(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2
CC         Na(+)(out); Xref=Rhea:RHEA:53492, ChEBI:CHEBI:29101,
CC         ChEBI:CHEBI:58103, ChEBI:CHEBI:58116, ChEBI:CHEBI:58286,
CC         ChEBI:CHEBI:58319; EC=2.1.1.86; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01501};
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); methyl-
CC       coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step
CC       2/2. {ECO:0000255|HAMAP-Rule:MF_01501}.
CC   -!- SUBUNIT: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD,
CC       MtrE, MtrF, MtrG and MtrH. {ECO:0000255|HAMAP-Rule:MF_01501}.
CC   -!- SIMILARITY: Belongs to the MtrH family. {ECO:0000255|HAMAP-
CC       Rule:MF_01501}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB98859.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; L77117; AAB98859.1; ALT_INIT; Genomic_DNA.
DR   PIR; F64406; F64406.
DR   RefSeq; WP_010870368.1; NC_000909.1.
DR   AlphaFoldDB; Q58264; -.
DR   SMR; Q58264; -.
DR   STRING; 243232.MJ_0854; -.
DR   DNASU; 1451742; -.
DR   EnsemblBacteria; AAB98859; AAB98859; MJ_0854.
DR   GeneID; 1451742; -.
DR   KEGG; mja:MJ_0854; -.
DR   eggNOG; arCOG04336; Archaea.
DR   HOGENOM; CLU_048697_0_0_2; -.
DR   InParanoid; Q58264; -.
DR   OMA; YARHKIV; -.
DR   OrthoDB; 86442at2157; -.
DR   PhylomeDB; Q58264; -.
DR   UniPathway; UPA00640; UER00698.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0030269; F:tetrahydromethanopterin S-methyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.20.20.20; -; 1.
DR   HAMAP; MF_01501; MtrH; 1.
DR   InterPro; IPR011005; Dihydropteroate_synth-like.
DR   InterPro; IPR023467; MeTrfase_MtrH/MtxH.
DR   InterPro; IPR028342; MtrH.
DR   Pfam; PF02007; MtrH; 1.
DR   PIRSF; PIRSF500206; MtrH; 1.
DR   PIRSF; PIRSF004960; MtrH_MtxH; 1.
DR   SUPFAM; SSF51717; SSF51717; 1.
DR   TIGRFAMs; TIGR01114; mtrH; 1.
PE   3: Inferred from homology;
KW   Methanogenesis; Methyltransferase; One-carbon metabolism;
KW   Reference proteome; Transferase.
FT   CHAIN           1..319
FT                   /note="Tetrahydromethanopterin S-methyltransferase subunit
FT                   H"
FT                   /id="PRO_0000147563"
SQ   SEQUENCE   319 AA;  34603 MW;  370E20B41F5CDA00 CRC64;
     MFKFDREQMV VEIAGRKIGG QPGEYPTALA GTIFYARHKI VEDERKGIFD KAAAEDLINK
     QAEMEDITGN PALVQVFGGT PEALVNYIDF VAEVWDGPML LDSTSGEARM AAAKRATEAG
     YAKQCIYNSI NVSIDEQEYQ VLVESDLEAS IVLCFDPMDP TVEGKINVLT NGGKTADKGM
     LELAEKAGIK YPLIDTAVTP LGNGAGAAVR ASFAVKALFG YPVGSGIHNI PSAWDWLREF
     RKQLREAGER EKAKDIHHVC DVGANLVQVM ASGDFVLYGP IDNAYMTFPA VAMVDAIIAE
     AAKELGIEPI DTHPFKKLV