ID   MTRH_METTH              Reviewed;         310 AA.
AC   O27224;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 123.
DE   RecName: Full=Tetrahydromethanopterin S-methyltransferase subunit H {ECO:0000255|HAMAP-Rule:MF_01501};
DE            EC=2.1.1.86 {ECO:0000255|HAMAP-Rule:MF_01501};
DE   AltName: Full=N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit H {ECO:0000255|HAMAP-Rule:MF_01501};
GN   Name=mtrH {ECO:0000255|HAMAP-Rule:MF_01501}; OrderedLocusNames=MTH_1156;
OS   Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS   10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=187420;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX   PubMed=9371463; DOI=10.1128/jb.179.22.7135-7155.1997;
RA   Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA   Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA   Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA   Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA   Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA   Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J.,
RA   Reeve J.N.;
RT   "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT   functional analysis and comparative genomics.";
RL   J. Bacteriol. 179:7135-7155(1997).
CC   -!- FUNCTION: Part of a complex that catalyzes the formation of methyl-
CC       coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-
CC       tetrahydromethanopterin. This is an energy-conserving, sodium-ion
CC       translocating step. MtrH catalyzes the transfer of the methyl group
CC       from methyl-tetrahydromethanopterin to the corrinoid prosthetic group
CC       of MtrA. {ECO:0000255|HAMAP-Rule:MF_01501}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2
CC         Na(+)(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2
CC         Na(+)(out); Xref=Rhea:RHEA:53492, ChEBI:CHEBI:29101,
CC         ChEBI:CHEBI:58103, ChEBI:CHEBI:58116, ChEBI:CHEBI:58286,
CC         ChEBI:CHEBI:58319; EC=2.1.1.86; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01501};
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); methyl-
CC       coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step
CC       2/2. {ECO:0000255|HAMAP-Rule:MF_01501}.
CC   -!- SUBUNIT: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD,
CC       MtrE, MtrF, MtrG and MtrH. {ECO:0000255|HAMAP-Rule:MF_01501}.
CC   -!- SIMILARITY: Belongs to the MtrH family. {ECO:0000255|HAMAP-
CC       Rule:MF_01501}.
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DR   EMBL; AE000666; AAB85645.1; -; Genomic_DNA.
DR   PIR; A69021; A69021.
DR   RefSeq; WP_010876780.1; NC_000916.1.
DR   AlphaFoldDB; O27224; -.
DR   SMR; O27224; -.
DR   IntAct; O27224; 1.
DR   STRING; 187420.MTH_1156; -.
DR   EnsemblBacteria; AAB85645; AAB85645; MTH_1156.
DR   GeneID; 1471564; -.
DR   KEGG; mth:MTH_1156; -.
DR   PATRIC; fig|187420.15.peg.1133; -.
DR   HOGENOM; CLU_048697_0_0_2; -.
DR   OMA; YARHKIV; -.
DR   UniPathway; UPA00640; UER00698.
DR   Proteomes; UP000005223; Chromosome.
DR   GO; GO:0030269; F:tetrahydromethanopterin S-methyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.20.20.20; -; 1.
DR   HAMAP; MF_01501; MtrH; 1.
DR   InterPro; IPR011005; Dihydropteroate_synth-like.
DR   InterPro; IPR023467; MeTrfase_MtrH/MtxH.
DR   InterPro; IPR028342; MtrH.
DR   Pfam; PF02007; MtrH; 1.
DR   PIRSF; PIRSF500206; MtrH; 1.
DR   PIRSF; PIRSF004960; MtrH_MtxH; 1.
DR   SUPFAM; SSF51717; SSF51717; 1.
DR   TIGRFAMs; TIGR01114; mtrH; 1.
PE   3: Inferred from homology;
KW   Methanogenesis; Methyltransferase; One-carbon metabolism;
KW   Reference proteome; Transferase.
FT   CHAIN           1..310
FT                   /note="Tetrahydromethanopterin S-methyltransferase subunit
FT                   H"
FT                   /id="PRO_0000147567"
SQ   SEQUENCE   310 AA;  33428 MW;  BDD5F14EA05ABA1F CRC64;
     MFRFDKEQIV LDIAGTKIGG QPGEYPTVLA GTIFYGGHSI IEDEKAGVFD KDKAEALIKT
     QEEMSDVTGN PHIVQTFGQT PEAIVKYLEF VGDVTDAPFF IDSTSGEARI AGANYASEVG
     LEDRAIYNSV NMAADEAELE ALKETKLSAS IVLGFNPMDP TVDGKIGIWE DGAGTIDKGL
     LEMAAECGID KYLMDVAVTP LGQGAGVAVR TSFAVKSKWG YPVGSGIHNV PSAWDWLREY
     KKDHKEAWPV CDVGSNLIQQ MAGGDFVLYG PIENAKMAFP ACAMADIFIS EAAKDIGTEP
     VEDHPFFKLL