ID   MTRM_DROYA              Reviewed;         219 AA.
AC   P83733;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   02-FEB-2004, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Protein matrimony;
DE   AltName: Full=Cell cycle arrest protein D52;
GN   Name=mtrm;
OS   Drosophila yakuba (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7245;
RN   [1] {ECO:0000312|EMBL:AAQ09875.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=14525923; DOI=10.1101/gr.1311003;
RA   Domazet-Loso T., Tautz D.;
RT   "An evolutionary analysis of orphan genes in Drosophila.";
RL   Genome Res. 13:2213-2219(2003).
CC   -!- FUNCTION: Polo kinase inhibitor required to maintain G2 arrest in the
CC       meiotic cell cycle in females. Holds heterochromatically paired
CC       homologs together from the end of pachytene until metaphase I.
CC       Haploinsufficient locus for homologous achiasmate segregation and may
CC       be required for the maintenance of heterochromatic pairings.
CC       {ECO:0000250|UniProtKB:Q23973}.
CC   -!- SUBUNIT: Interacts with polo. Interacts with cort.
CC       {ECO:0000250|UniProtKB:Q23973}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q23973}.
CC       Chromosome {ECO:0000250|UniProtKB:Q23973}.
CC   -!- PTM: Probably ubiquitinated: degraded during the oocyte-to-embryo
CC       transition by the anaphase promoting complex/cyclosome (APC/C)
CC       containing cort protein. {ECO:0000250|UniProtKB:Q23973}.
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DR   EMBL; AF531976; AAQ09875.1; -; mRNA.
DR   AlphaFoldDB; P83733; -.
DR   SMR; P83733; -.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0032837; P:distributive segregation; IEA:EnsemblMetazoa.
DR   GO; GO:0016321; P:female meiosis chromosome segregation; IEA:EnsemblMetazoa.
DR   GO; GO:0045143; P:homologous chromosome segregation; ISS:UniProtKB.
DR   GO; GO:0051445; P:regulation of meiotic cell cycle; IEA:EnsemblMetazoa.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   Pfam; PF07647; SAM_2; 1.
DR   SMART; SM00454; SAM; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS50105; SAM_DOMAIN; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Chromosome; DNA-binding; Meiosis; Nucleus; Ubl conjugation.
FT   CHAIN           1..219
FT                   /note="Protein matrimony"
FT                   /id="PRO_0000096636"
FT   DOMAIN          159..219
FT                   /note="SAM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
FT   REGION          74..104
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        74..99
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   219 AA;  25205 MW;  7127B657569EF603 CRC64;
     MENCRTPTNK TQITLNRTPT LKERRWNTLK VNTTNVRCST PIFGNFRSPN LSPIESMGTK
     KSPVSPMRFA FKKPPAKAHP HPHQHQHHHH HHKHIHRTQL KPPPFILPKP QEEIIEPERE
     IKICSSPDTF SDDSNMETSL VVESRRRSIK ASNHSYVVNH AANVEQILMH MGLENYVTNF
     EEAHIDLVKL ASMERADLVK IGLNADEDCN RIMDVLQTL