MTRTR_BACSU
ID MTRTR_BACSU Reviewed; 461 AA.
AC Q797A7; O06479;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Methylthioribose transporter {ECO:0000305};
GN Name=mtrA {ECO:0000303|PubMed:29280348}; Synonyms=yfnA;
GN OrderedLocusNames=BSU07340;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168 / AC327;
RX PubMed=9141694; DOI=10.1099/00221287-143-4-1317;
RA Yamamoto H., Uchiyama S., Nugroho F.A., Sekiguchi J.;
RT "A 23.4 kb segment at the 69 degrees-70 degrees region of the Bacillus
RT subtilis genome.";
RL Microbiology 143:1317-1320(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=29280348; DOI=10.1111/1751-7915.13043;
RA Borriss R., Danchin A., Harwood C.R., Medigue C., Rocha E.P.C.,
RA Sekowska A., Vallenet D.;
RT "Bacillus subtilis, the model Gram-positive bacterium: 20 years of
RT annotation refinement.";
RL Microb. Biotechnol. 11:3-17(2018).
CC -!- FUNCTION: Involved in import of methylthioribose (MTR) into the cell.
CC {ECO:0000269|PubMed:29280348}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- DISRUPTION PHENOTYPE: Disruption of the gene leads to almost full
CC resistance to trifluoromethylthioribose (3FMTR), a toxic analog of MTR.
CC {ECO:0000269|PubMed:29280348}.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA20110.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; D86418; BAA20110.1; ALT_INIT; Genomic_DNA.
DR EMBL; AL009126; CAB12553.1; -; Genomic_DNA.
DR PIR; D69814; D69814.
DR RefSeq; NP_388615.1; NC_000964.3.
DR RefSeq; WP_003242995.1; NZ_JNCM01000032.1.
DR AlphaFoldDB; Q797A7; -.
DR SMR; Q797A7; -.
DR STRING; 224308.BSU07340; -.
DR PaxDb; Q797A7; -.
DR PRIDE; Q797A7; -.
DR EnsemblBacteria; CAB12553; CAB12553; BSU_07340.
DR GeneID; 936098; -.
DR KEGG; bsu:BSU07340; -.
DR PATRIC; fig|224308.179.peg.796; -.
DR eggNOG; COG0531; Bacteria.
DR InParanoid; Q797A7; -.
DR OMA; WFAKTHP; -.
DR PhylomeDB; Q797A7; -.
DR BioCyc; BSUB:BSU07340-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015171; F:amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006865; P:amino acid transport; IBA:GO_Central.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR InterPro; IPR002293; AA/rel_permease1.
DR Pfam; PF13520; AA_permease_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Reference proteome; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..461
FT /note="Methylthioribose transporter"
FT /id="PRO_0000360829"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..172
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 213..233
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 254..274
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..321
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 355..375
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 376..396
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 409..429
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 432..452
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 461 AA; 48905 MW; 804576AE3809E6C2 CRC64;
MSSLFRKKPL ETLSAQSKSK SLARTLSAFD LTLLGIGCVI GTGIFVITGT VAATGAGPAL
IISFILAGLA CALAAFCYAE FSSSIPISGS VYSYSYVTLG ELLAFLIGWD LMLEYVIALS
AVATGWSSYF QSLLAGFNLH IPAALTGAPG SMAGAVFNLP AAVIILLITA IVSRGVKEST
RFNNVIVLMK IAIILLFIIV GIGYVKPDNW SPFMPFGMKG VILSAATVFF AYLGFDAVSN
ASEEVKNPQK NMPVGIISAL AVCTVLYIAV SLVLTGMMPY AKLNVGDPVS FALKFVGQDA
VAGIISVGAI IGITTVMLAL LYAQVRLTFA MSRDGLLPGL FAKVHPSFKT PFRNTWLTGI
VAAGIAGFIN LGTLAHLVNM GTLAAFTVIS IAVIVLRKKH PEIKASFRVP FVPVVPIISA
GICLWFMYSL PGVTWLSFVI WIAVGTLVYF LYSRKHSLLN K
