ID   MTRX_AMPV1              Reviewed;         254 AA.
AC   Q2Y2M4;
DT   15-DEC-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   23-FEB-2022, entry version 41.
DE   RecName: Full=Matrix protein;
GN   Name=M;
OS   Avian metapneumovirus (isolate Canada goose/Minnesota/15a/2001) (AMPV).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Pneumoviridae; Metapneumovirus.
OX   NCBI_TaxID=652954;
OH   NCBI_TaxID=8847; Anser sp. (goose).
OH   NCBI_TaxID=9103; Meleagris gallopavo (Wild turkey).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=15666873; DOI=10.1637/7208-051804r;
RA   Bennett R.S., Nezworski J., Velayudhan B.T., Nagaraja K.V., Zeman D.H.,
RA   Dyer N., Graham T., Lauer D.C., Njenga M.K., Halvorson D.A.;
RT   "Evidence of avian pneumovirus spread beyond Minnesota among wild and
RT   domestic birds in central North America.";
RL   Avian Dis. 48:902-908(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=16282483; DOI=10.1128/jvi.79.23.14834-14842.2005;
RA   Bennett R.S., LaRue R., Shaw D., Yu Q., Nagaraja K.V., Halvorson D.A.,
RA   Njenga M.K.;
RT   "A wild goose metapneumovirus containing a large attachment glycoprotein is
RT   avirulent but immunoprotective in domestic turkeys.";
RL   J. Virol. 79:14834-14842(2005).
CC   -!- FUNCTION: Has a crucial role in virus assembly and budding. The matrix
CC       interacts with the RNP complex and this association serves two
CC       functions: facilitate virion assembly and inhibit the viral
CC       transcriptase activity. Early in infection, M is localized to the
CC       nucleus and may inhibit host cell transcription. Later on, M can
CC       associate with lipid rafts supposely by interacting with the
CC       cytoskeleton and with the cytoplasmic tail of glycoprotein G. The
CC       binding of M to host membrane is stabilized by the surface expression
CC       of the viral glycoproteins. These interactions may allow virus
CC       formation by mediating association of the nucleocapsid with the nascent
CC       envelope (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with glycoprotein G (via N-terminus), and protein N.
CC       Interacts with protein M2-1; this interaction mediates the association
CC       between proteins M and N (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Host cytoplasm
CC       {ECO:0000250}. Host nucleus {ECO:0000250}. Host cell membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC       side {ECO:0000250}. Note=During bud formation, associates at the inner
CC       side of the plasma membrane of infected cells. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the paramyxoviruses M protein family.
CC       {ECO:0000305}.
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DR   EMBL; DQ009484; AAY81656.1; -; Viral_cRNA.
DR   RefSeq; YP_443839.1; NC_007652.1.
DR   SMR; Q2Y2M4; -.
DR   PRIDE; Q2Y2M4; -.
DR   Proteomes; UP000002471; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:InterPro.
DR   GO; GO:0039660; F:structural constituent of virion; IEA:UniProtKB-KW.
DR   GO; GO:0019068; P:virion assembly; IEA:InterPro.
DR   Gene3D; 2.70.20.30; -; 1.
DR   InterPro; IPR005056; Pneu_matrix.
DR   InterPro; IPR043062; Pneu_matrix_N.
DR   Pfam; PF03393; Pneumo_matrix; 1.
PE   3: Inferred from homology;
KW   Host cell membrane; Host cytoplasm; Host membrane; Host nucleus;
KW   Host-virus interaction; Membrane; Reference proteome; Viral matrix protein;
KW   Virion.
FT   CHAIN           1..254
FT                   /note="Matrix protein"
FT                   /id="PRO_0000390369"
SQ   SEQUENCE   254 AA;  27622 MW;  73DACAB5E03304A4 CRC64;
     MESYLVDTYQ GVPYTAAVQT DLVEKDQLPA RLTVWFPLFQ TNTPPTVLLE QLKTLTITTL
     YTASQNGPIL KVNASAQGAA MSALPKSFDV SASVALDDYS KLEFDKLTVC ELKAVYLTTM
     KPYGMVSKFV NSAKAVGKKT HDLIALCDFL DLEKGVPVTI PAYIKSVSIK ESESATVEAA
     IGGEADQAIT QARIAPYAGL IMIMTMNNPK GIFKKLGAGV QVIVELGAYV QAESISRICR
     NWSHQGTRYV LKSR