ID   MTR_HAEIN               Reviewed;         418 AA.
AC   P44614;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Tryptophan-specific transport protein;
DE   AltName: Full=Tryptophan permease;
GN   Name=mtr; OrderedLocusNames=HI_0287;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Involved in transporting tryptophan across the cytoplasmic
CC       membrane. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC       Mtr/TnaB/TyrP permease subfamily. {ECO:0000305}.
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DR   EMBL; L42023; AAC21952.1; -; Genomic_DNA.
DR   PIR; F64059; F64059.
DR   RefSeq; NP_438454.1; NC_000907.1.
DR   RefSeq; WP_005694021.1; NC_000907.1.
DR   AlphaFoldDB; P44614; -.
DR   SMR; P44614; -.
DR   STRING; 71421.HI_0287; -.
DR   EnsemblBacteria; AAC21952; AAC21952; HI_0287.
DR   KEGG; hin:HI_0287; -.
DR   PATRIC; fig|71421.8.peg.303; -.
DR   eggNOG; COG0814; Bacteria.
DR   HOGENOM; CLU_038102_2_1_6; -.
DR   OMA; LVKYYDR; -.
DR   PhylomeDB; P44614; -.
DR   BioCyc; HINF71421:G1GJ1-305-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0015173; F:aromatic amino acid transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR018227; Amino_acid_transport_2.
DR   InterPro; IPR013061; Trp/try_permease_CS.
DR   InterPro; IPR013059; Trp_tyr_transpt.
DR   PANTHER; PTHR46997; PTHR46997; 1.
DR   Pfam; PF03222; Trp_Tyr_perm; 1.
DR   PRINTS; PR00166; AROAAPRMEASE.
DR   TIGRFAMs; TIGR00837; araaP; 1.
DR   PROSITE; PS00594; AROMATIC_AA_PERMEASE_1; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Cell inner membrane; Cell membrane; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..418
FT                   /note="Tryptophan-specific transport protein"
FT                   /id="PRO_0000093798"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        33..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        154..174
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        194..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        232..252
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        289..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        330..347
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        354..370
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        384..404
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   418 AA;  45018 MW;  B6DB96E6314A2A57 CRC64;
     MIQQKSPSLL GGAMIIAGTA IGAGMLANPT STAGVWFIGS ILALIYTWFC MTTSGLMILE
     ANLHYPTGSS FDTIVKDLLG KSWNTINGLS VAFVLYILTY AYITSGGGIT QNLLNQAFSS
     AESAVDIGRT SGSLIFCLIL AAFVWLSTKA VDRFTTVLIV GMVVAFFLST TGLLSSVKTA
     VLFNTVAESE QTYLPYLLTA LPVCLVSFGF HGNVPSLVKY YDRDGRRVMK SIFIGTGLAL
     VIYILWQLAV QGNLPRTEFA PVIEKGGDVS ALLEALHKYI EVEYLSVALN FFAYMAISTS
     FLGVTLGLFD YIADLFKFDD SLLGRTKTTL VTFLPPLLLS LQFPYGFVIA IGYAGLAATI
     WAAIVPALLA KASRQKFPQA SYKVYGGNFM IGFVILFGIL NIVAQIGANL GWFASFTG