MTR_NEUCR
ID MTR_NEUCR Reviewed; 470 AA.
AC P38680; Q7RVG6;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=N amino acid transport system protein;
DE AltName: Full=Methyltryptophan resistance protein;
GN Name=mtr; ORFNames=NCU06619;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Oak Ridge;
RX PubMed=8001794; DOI=10.1093/genetics/138.1.61;
RA Dillon D., Stadler D.;
RT "Spontaneous mutation at the mtr locus in neurospora: the molecular
RT spectrum in wild-type and a mutator strain.";
RL Genetics 138:61-74(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 210-470.
RX PubMed=1838345; DOI=10.1139/g91-098;
RA Koo K., Stuart W.D.;
RT "Sequence and structure of mtr, an amino acid transport gene of Neurospora
RT crassa.";
RL Genome 34:644-651(1991).
CC -!- FUNCTION: Required for the transport of neutral aliphatic and aromatic
CC amino acids via the N system.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC {ECO:0000305}.
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DR EMBL; L34605; AAA33600.1; -; Genomic_DNA.
DR EMBL; CM002239; EAA33125.1; -; Genomic_DNA.
DR EMBL; S81767; AAB21410.1; -; Genomic_DNA.
DR PIR; S47892; S47892.
DR RefSeq; XP_962361.1; XM_957268.2.
DR AlphaFoldDB; P38680; -.
DR SMR; P38680; -.
DR STRING; 5141.EFNCRP00000006372; -.
DR TCDB; 2.A.18.4.1; the amino acid/auxin permease (aaap) family.
DR EnsemblFungi; EAA33125; EAA33125; NCU06619.
DR GeneID; 3878509; -.
DR KEGG; ncr:NCU06619; -.
DR VEuPathDB; FungiDB:NCU06619; -.
DR HOGENOM; CLU_027816_4_0_1; -.
DR InParanoid; P38680; -.
DR OMA; DAGRLMF; -.
DR Proteomes; UP000001805; Chromosome 4, Linkage Group IV.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015179; F:L-amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0003333; P:amino acid transmembrane transport; IBA:GO_Central.
DR InterPro; IPR013057; AA_transpt_TM.
DR Pfam; PF01490; Aa_trans; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..470
FT /note="N amino acid transport system protein"
FT /id="PRO_0000093819"
FT TOPO_DOM 1..56
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 99..131
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..152
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 153..168
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 212..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..275
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..296
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 297..316
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 317..337
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 338..357
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 358..378
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 379..386
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 387..407
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 408..427
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 428..448
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 449..470
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 470 AA; 51162 MW; E8132D1A62373300 CRC64;
MDSQYETKKN DPNAIMPYPE SNDEHVGEVR GLGGGIMDKE PEAQEGHAKF HRLGWKRLTV
VLIVEAIALG SLSLPGAFAT LGMVPGVILS VGMGLICIYT AHVIGQTKLK HPEIAHYADV
GRVMFGRWGY EIISFMFVLQ LIFIVGSHVL TGTIMWGTIT DNGNGTCSLV FGIVSAIILF
LLAIPPSFAE VAILGYIDFV SICAAILITM IATGIRSSHQ EGGLAAVPWS CWPKEDLSLA
EGFIAVSNIV FAYSFAMCQF SFMDEMHTPS DYKKSIVALG LIEIFIYTVT GGVVYAFVGP
EVQSPALLSA GPLLAKVAFG IALPVIFISG SINTVVVSRY LIERIWPNNV IRYVNTPAGW
MVWLGFDFGI TLIAWVIAEA IPFFSDLLAI CSALFISGFS FYFPALMYFK ITRNDAKSQG
KKYFLDALNM LCFVIGMGIL GIGTYAAIQD IMDRYDHGKV SKPYSCAPLA
