MTR_PSEAB
ID MTR_PSEAB Reviewed; 417 AA.
AC Q02DS7;
DT 26-NOV-2014, integrated into UniProtKB/Swiss-Prot.
DT 14-NOV-2006, sequence version 1.
DT 03-AUG-2022, entry version 67.
DE RecName: Full=Tryptophan-specific transport protein;
DE AltName: Full=Tryptophan permease;
GN Name=mtr; OrderedLocusNames=PA14_71710;
OS Pseudomonas aeruginosa (strain UCBPP-PA14).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208963;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UCBPP-PA14;
RX PubMed=17038190; DOI=10.1186/gb-2006-7-10-r90;
RA Lee D.G., Urbach J.M., Wu G., Liberati N.T., Feinbaum R.L., Miyata S.,
RA Diggins L.T., He J., Saucier M., Deziel E., Friedman L., Li L., Grills G.,
RA Montgomery K., Kucherlapati R., Rahme L.G., Ausubel F.M.;
RT "Genomic analysis reveals that Pseudomonas aeruginosa virulence is
RT combinatorial.";
RL Genome Biol. 7:R90.1-R90.14(2006).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION, AND
RP PHOSPHORYLATION AT THR-8.
RC STRAIN=UCBPP-PA14;
RX PubMed=24965220; DOI=10.1002/pmic.201400190;
RA Ouidir T., Jarnier F., Cosette P., Jouenne T., Hardouin J.;
RT "Extracellular Ser/Thr/Tyr phosphorylated proteins of Pseudomonas
RT aeruginosa PA14 strain.";
RL Proteomics 14:2017-2030(2014).
CC -!- FUNCTION: Involved in transporting tryptophan across the cytoplasmic
CC membrane. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC Secreted {ECO:0000269|PubMed:24965220}. Note=Could be present
CC extracellularly due to cell lysis. {ECO:0000305}.
CC -!- INDUCTION: By phenylalanine under the control of regulatory protein
CC TyrR. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC Mtr/TnaB/TyrP permease subfamily. {ECO:0000305}.
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DR EMBL; CP000438; ABJ14818.1; -; Genomic_DNA.
DR RefSeq; WP_003096841.1; NZ_CP034244.1.
DR AlphaFoldDB; Q02DS7; -.
DR iPTMnet; Q02DS7; -.
DR EnsemblBacteria; ABJ14818; ABJ14818; PA14_71710.
DR KEGG; pau:PA14_71710; -.
DR HOGENOM; CLU_038102_2_1_6; -.
DR OMA; LVKYYDR; -.
DR BioCyc; PAER208963:G1G74-6036-MON; -.
DR Proteomes; UP000000653; Chromosome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR GO; GO:0015173; F:aromatic amino acid transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR018227; Amino_acid_transport_2.
DR InterPro; IPR013059; Trp_tyr_transpt.
DR PANTHER; PTHR46997; PTHR46997; 1.
DR Pfam; PF03222; Trp_Tyr_perm; 1.
DR PRINTS; PR00166; AROAAPRMEASE.
DR TIGRFAMs; TIGR00837; araaP; 1.
PE 1: Evidence at protein level;
KW Amino-acid transport; Cell inner membrane; Cell membrane; Membrane;
KW Phosphoprotein; Secreted; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..417
FT /note="Tryptophan-specific transport protein"
FT /id="PRO_0000431334"
FT TRANSMEM 16..36
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 40..60
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..117
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..146
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 232..252
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TRANSMEM 295..315
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TRANSMEM 326..346
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TRANSMEM 347..367
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TRANSMEM 390..410
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT MOD_RES 8
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:24965220"
SQ SEQUENCE 417 AA; 44742 MW; A11F8DBB3D371C73 CRC64;
MSSSPAQTPS RRPSLLGGSM IIAGTAVGAG MFSLPIAMSG IWFGWSVAVF LLTWFCMLLS
GMMILEANLN YPVGSSFSTI TRDLLGQGWN VVNGLSIAFV LYILTYAYIS GGGSIIGYTL
SSGLGVTLPE KLAGLLFALA VALVVWWSTR AVDRITTLML GGMIITFGLS ISGLLGRIQP
AILFNSGEPD AVYWPYLLAT LPFCLTSFGY HGNVPSLMKY YGKDPQRISR SLWIGTLIAL
AIYLLWQAST LGTIPREQFK GIIAGGSNVG TLVEYLHRIT ASDSLNALLT TFSNLAVASS
FLGVTLGLFD YLADLCRFDD SHFGRFKTAL LTFVPPTIGG LLFPNGFIYA IGFAGLAAAF
WAVIVPALMA RASRKRFGSP LFRAWGGTPA IVLVLLFGVA NAVAHILASL HWLPEYR
