ID   MTSB_STRGN              Reviewed;         278 AA.
AC   P42361;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Manganese import system permease protein ScaB {ECO:0000305};
DE   AltName: Full=ORF2 {ECO:0000303|PubMed:7927711};
GN   Name=scaB {ECO:0000303|PubMed:9440518};
OS   Streptococcus gordonii.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=1302;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 51656 / PK488;
RX   PubMed=7927711; DOI=10.1128/iai.62.10.4469-4480.1994;
RA   Kolenbrander P.E., Andersen R.N., Ganeshkumar N.;
RT   "Nucleotide sequence of the Streptococcus gordonii PK488 coaggregation
RT   adhesin gene, scaA, and ATP-binding cassette.";
RL   Infect. Immun. 62:4469-4480(1994).
RN   [2]
RP   FUNCTION.
RC   STRAIN=ATCC 51656 / PK488, and
RC   Challis / ATCC 35105 / BCRC 15272 / CH1 / DL1 / V288;
RX   PubMed=9440518; DOI=10.1128/jb.180.2.290-295.1998;
RA   Kolenbrander P.E., Andersen R.N., Baker R.A., Jenkinson H.F.;
RT   "The adhesion-associated sca operon in Streptococcus gordonii encodes an
RT   inducible high-affinity ABC transporter for Mn2+ uptake.";
RL   J. Bacteriol. 180:290-295(1998).
CC   -!- FUNCTION: Part of the high-affinity ABC transporter complex ScaABC
CC       involved in manganese import. Probably responsible for the
CC       translocation of the substrate across the membrane. Essential for
CC       growth under Mn(2+)-limiting conditions. {ECO:0000269|PubMed:9440518}.
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (ScaC),
CC       two transmembrane proteins (ScaB) and a solute-binding protein (ScaA).
CC       {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the ABC-3 integral membrane protein family.
CC       {ECO:0000305}.
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DR   EMBL; L11577; AAA71946.1; -; Genomic_DNA.
DR   PIR; T11550; T11550.
DR   RefSeq; WP_045504337.1; NZ_KQ759749.1.
DR   AlphaFoldDB; P42361; -.
DR   SMR; P42361; -.
DR   TCDB; 3.A.1.15.2; the atp-binding cassette (abc) superfamily.
DR   GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   Gene3D; 1.10.3470.10; -; 1.
DR   InterPro; IPR037294; ABC_BtuC-like.
DR   InterPro; IPR001626; ABC_TroCD.
DR   PANTHER; PTHR30477; PTHR30477; 1.
DR   Pfam; PF00950; ABC-3; 1.
DR   SUPFAM; SSF81345; SSF81345; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Manganese; Membrane; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..278
FT                   /note="Manganese import system permease protein ScaB"
FT                   /id="PRO_0000171176"
FT   TRANSMEM        18..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        61..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        94..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        134..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        174..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        222..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        246..266
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   278 AA;  29705 MW;  47C1117C97DE084C CRC64;
     MIQEFIQGLH DFHFLQNALI TAIVIGVVAG AVGCFIILRG MSLMGDAISH AVLPGVALSF
     ILGINFFIGA ITFGLLASII ITYIKGNSII KSDTAIGITF SSFLALGIIL ISVAKSSTDL
     FHILFGNILA VQDLDMWISI GVGILVLLVI SIFFKQLLLT SFDPLLAQAM GMKVNFYHYL
     LMILLTLVSV TAMQSVGTIL IVAMLITPAA TAYLYAKSLK TMILLSSALG AGASVLGLFI
     GYSFNVAAGS SIVLTSALIF LVSFFIAPKQ RYLKRKVK