MTSH_DROME
ID MTSH_DROME Reviewed; 649 AA.
AC Q9VLP4;
DT 11-MAY-2016, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 2.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Protein mitoshell {ECO:0000312|FlyBase:FBgn0262598};
GN Name=mtsh {ECO:0000312|FlyBase:FBgn0262598};
GN ORFNames=CG7795 {ECO:0000312|FlyBase:FBgn0262598};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000312|Proteomes:UP000000803};
RN [1] {ECO:0000312|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000312|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000305}
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=20491580; DOI=10.1089/dna.2009.0989;
RA Bergner L.M., Hickman F.E., Wood K.H., Wakeman C.M., Stone H.H.,
RA Campbell T.J., Lightcap S.B., Favors S.M., Aldridge A.C., Hales K.G.;
RT "A novel predicted bromodomain-related protein affects coordination between
RT meiosis and spermiogenesis in Drosophila and is required for male meiotic
RT cytokinesis.";
RL DNA Cell Biol. 29:487-498(2010).
CC -!- FUNCTION: Required for male meiotic cytokinesis through its involvement
CC in the regulation of mitochondrial aggregation and fusion, astral
CC spindle assembly and contractile ring formation.
CC {ECO:0000269|PubMed:20491580}.
CC -!- DISRUPTION PHENOTYPE: Mutants are viable and females are fully fertile.
CC Males show premature mitochondrial aggregation and fusion in
CC spermatocytes and spermatids, leading to an aberrant mitochondrial
CC shell around premeiotic nuclei. Improper mitochondrial localization
CC occurs in the testis associated with defective central astral spindles
CC and a lack of contractile rings which leads to meiotic cytokinesis
CC failure. {ECO:0000269|PubMed:20491580}.
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DR EMBL; AE014134; AAF52640.2; -; Genomic_DNA.
DR RefSeq; NP_609208.2; NM_135364.3.
DR AlphaFoldDB; Q9VLP4; -.
DR SMR; Q9VLP4; -.
DR IntAct; Q9VLP4; 2.
DR STRING; 7227.FBpp0290393; -.
DR PaxDb; Q9VLP4; -.
DR PRIDE; Q9VLP4; -.
DR DNASU; 34141; -.
DR EnsemblMetazoa; FBtr0301170; FBpp0290393; FBgn0262598.
DR GeneID; 34141; -.
DR KEGG; dme:Dmel_CG7795; -.
DR UCSC; CG7795-RA; d. melanogaster.
DR CTD; 34141; -.
DR FlyBase; FBgn0262598; mtsh.
DR VEuPathDB; VectorBase:FBgn0262598; -.
DR eggNOG; ENOG502SCTB; Eukaryota.
DR HOGENOM; CLU_374803_0_0_1; -.
DR InParanoid; Q9VLP4; -.
DR OMA; DHIMGRP; -.
DR PhylomeDB; Q9VLP4; -.
DR BioGRID-ORCS; 34141; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 34141; -.
DR PRO; PR:Q9VLP4; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0262598; Expressed in testis and 10 other tissues.
DR ExpressionAtlas; Q9VLP4; baseline and differential.
DR GO; GO:0055050; P:astral spindle assembly involved in male meiosis; IMP:FlyBase.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007112; P:male meiosis cytokinesis; IMP:FlyBase.
DR GO; GO:0010635; P:regulation of mitochondrial fusion; IMP:FlyBase.
DR GO; GO:0007283; P:spermatogenesis; IMP:FlyBase.
PE 4: Predicted;
KW Cell cycle; Cell division; Differentiation; Meiosis; Reference proteome;
KW Spermatogenesis.
FT CHAIN 1..649
FT /note="Protein mitoshell"
FT /evidence="ECO:0000305"
FT /id="PRO_0000436180"
FT REGION 167..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 485..512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 485..510
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 649 AA; 73680 MW; F37C496196FB4A34 CRC64;
MNIPIYQVPS VTMQSLHQQS LYQQTYLDRN RMVTDVFVQE HVSQSSWSMA GSSAVFIPGP
IITGSAHGHC HHTATVSTVS PQLATFMPFP GMQYYAASSA TMNAYGHNQM YSTRASASVG
FYLPQYHASC SHEQPKKTFC AAQTQTQQTA KTSCDVGTQV DLDAEELRSE ARKPRPESVV
PEESSISSLE SGAGDGFRVQ KKLRNSEVKL LDQRLHDITR VSLHGSEIAE RLANAHRNRP
CFKKIDTLCA RLKQDLLRPD GVLPNINSQG IAWAVKDFIF VFTRIVNAWV ILKGYVYNTP
DALNKIKDEL PSGFMASFDS WQISTLSIVK MIVKSFVNLD ELLQKQKNSF SGKDGAPINQ
SNSISLRSFI DSNDSSGLAQ KYLGMTTGHG PSAFSTPNNQ IRNNAASKGQ EPTSSALYKP
KCALNLNYLY TMIEDSEETQ RHVDANGTYL KTGTYQPLQK ESMQLEMPPA KPNDHYVERN
ANQQALPSQE IPNAPTPKSS PQSDRPRDVR SYTNPFSAIG KEVTRQLYEF SDRVMELKNL
ERFFKKQFTR NYYPNFYQHC QDDFIDVRAI ILRCENSSYH HIYQAIHDLR RIIFTVRCYL
QMYTDENLLY YIDLYERSVN DMLSKPPHYP NQFDHIMGRP GEKLFNYEI
