ID   MTTB_METBF              Reviewed;         495 AA.
AC   P0C0W7;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 3.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Trimethylamine methyltransferase MttB;
DE            Short=TMA methyltransferase;
DE            EC=2.1.1.250;
DE   AltName: Full=Trimethylamine--corrinoid protein methyltransferase;
GN   Name=mttB; OrderedLocusNames=Mbar_A1502;
OS   Methanosarcina barkeri (strain Fusaro / DSM 804).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=269797;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Fusaro / DSM 804;
RX   PubMed=16980466; DOI=10.1128/jb.00810-06;
RA   Maeder D.L., Anderson I., Brettin T.S., Bruce D.C., Gilna P., Han C.S.,
RA   Lapidus A., Metcalf W.W., Saunders E., Tapia R., Sowers K.R.;
RT   "The Methanosarcina barkeri genome: comparative analysis with
RT   Methanosarcina acetivorans and Methanosarcina mazei reveals extensive
RT   rearrangement within methanosarcinal genomes.";
RL   J. Bacteriol. 188:7922-7931(2006).
CC   -!- FUNCTION: Catalyzes the transfer of a methyl group from trimethylamine
CC       to the corrinoid cofactor of MttC. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Co(I)-[trimethylamine-specific corrinoid protein] + H(+) +
CC         trimethylamine = dimethylamine + methyl-Co(III)-[trimethylamine-
CC         specific corrinoid protein]; Xref=Rhea:RHEA:39287, Rhea:RHEA-
CC         COMP:11124, Rhea:RHEA-COMP:11126, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:58040, ChEBI:CHEBI:58389, ChEBI:CHEBI:85033,
CC         ChEBI:CHEBI:85035; EC=2.1.1.250;
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from trimethylamine.
CC   -!- SIMILARITY: Belongs to the trimethylamine methyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; CP000099; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PRIDE; P0C0W7; -.
DR   UniPathway; UPA00645; -.
DR   GO; GO:0043834; F:trimethylamine methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0015948; P:methanogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.480; -; 1.
DR   InterPro; IPR038601; MttB-like_sf.
DR   InterPro; IPR012740; MttB_Methanosar.
DR   InterPro; IPR010426; MTTB_MeTrfase.
DR   Pfam; PF06253; MTTB; 1.
DR   PIRSF; PIRSF037567; MTTB_MeTrfase; 1.
DR   TIGRFAMs; TIGR02369; trimeth_pyl; 1.
PE   3: Inferred from homology;
KW   Methanogenesis; Methyltransferase; Pyrrolysine; Transferase.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..495
FT                   /note="Trimethylamine methyltransferase MttB"
FT                   /id="PRO_0000216570"
FT   NON_STD         334
FT                   /note="Pyrrolysine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   495 AA;  53900 MW;  C88B17FC30BD9E50 CRC64;
     MAKNNAVAGF NALNGVELNL FTTDELKAIH YATMEVLMDP GIQVSDPEAR QIFKENGCEV
     DEKTNVVKIP EYLVRKALQL APSRFILWGR DKKFNTVQEC GGKVHWTCFG TGVKMCKYQD
     GKYVTVDSVE KDIADIAKLC DWAENIDYFS LPVSARDIAG QGAQDVHETL TPIANTAKHF
     HHIDPVGENV EYYRDIVKAY YGGDEEEARK KPIFSMLLCP TSPLELSVNA CQVIIKGARY
     GIPVNVLSMA MSGGSSPVYL AGTLVTHNAE VLSGIVLAQL TVPGAKVWYG SSTTTFDLKK
     GTAPVGSPEL GLISAAVAKL AQFYGLPSYV AGSOSDAKVP DDQAGHEKTM TTLLPALSGA
     NTIYGAGMLE LGMTFSMEQL VIDNDIFSMV KKAMKGIPVS EETLAVESIQ KVGIGNNFLA
     LKQTRQLVDY PSNPMLLDRH MFGDWAAAGS KDLATVAHEK VEDVLKNHQV TPIDADILKD
     MQAIVDKADK AFRGM