ID   MTURN_BOVIN             Reviewed;         131 AA.
AC   A7MBJ1;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Maturin;
DE   AltName: Full=Maturin neural progenitor differentiation regulator protein homolog;
GN   Name=MTURN;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Promotes megakaryocyte differentiation by enhancing ERK and
CC       JNK signaling as well as up-regulating RUNX1 and FLI1 expression (By
CC       similarity). Represses NF-kappa-B transcriptional activity by
CC       inhibiting phosphorylation of RELA at 'Ser- 536' (By similarity). May
CC       be involved in early neuronal development (By similarity).
CC       {ECO:0000250|UniProtKB:Q7ZX36, ECO:0000250|UniProtKB:Q8N3F0}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8N3F0}.
CC   -!- PTM: Phosphorylation at Tyr-34 is essential for its ability to promote
CC       megakaryocyte differentiation. {ECO:0000250|UniProtKB:Q8N3F0}.
CC   -!- SIMILARITY: Belongs to the MTURN family. {ECO:0000305}.
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DR   EMBL; BC151589; AAI51590.1; -; mRNA.
DR   RefSeq; NP_001094716.1; NM_001101246.1.
DR   AlphaFoldDB; A7MBJ1; -.
DR   STRING; 9913.ENSBTAP00000049943; -.
DR   PaxDb; A7MBJ1; -.
DR   PRIDE; A7MBJ1; -.
DR   GeneID; 615685; -.
DR   KEGG; bta:615685; -.
DR   CTD; 222166; -.
DR   eggNOG; ENOG502RXQA; Eukaryota.
DR   HOGENOM; CLU_163056_0_0_1; -.
DR   InParanoid; A7MBJ1; -.
DR   OrthoDB; 1571561at2759; -.
DR   TreeFam; TF332814; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0045654; P:positive regulation of megakaryocyte differentiation; ISS:UniProtKB.
DR   InterPro; IPR027892; Maturin.
DR   PANTHER; PTHR32008; PTHR32008; 1.
DR   Pfam; PF15167; DUF4581; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; Phosphoprotein; Reference proteome.
FT   CHAIN           1..131
FT                   /note="Maturin"
FT                   /id="PRO_0000359896"
FT   REGION          107..131
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         34
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8N3F0"
SQ   SEQUENCE   131 AA;  14925 MW;  BD60297F085B5C59 CRC64;
     MDFQQLADVA EKWCSNTPFE LIATEETERR MDFYADPGVS FYVLCPDNGC GDNFHVWSES
     EDCLPFLQLA QDYISSCGKK TLHEVLEKVF KSFRPLLGLP DADDDAFEEY SADVEEEEPE
     ADHPQMGVSQ Q