ID   MTURN_DANRE             Reviewed;         133 AA.
AC   P0C8M4; B8JKY4;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-JAN-2009, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Maturin;
DE   AltName: Full=Maturin neural progenitor differentiation regulator protein homolog;
GN   Name=mturn; ORFNames=ch211-149a19.1;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   DEVELOPMENTAL STAGE.
RX   PubMed=24095902; DOI=10.1016/j.ydbio.2013.09.028;
RA   Martinez-De Luna R.I., Ku R.Y., Lyou Y., Zuber M.E.;
RT   "Maturin is a novel protein required for differentiation during primary
RT   neurogenesis.";
RL   Dev. Biol. 384:26-40(2013).
CC   -!- FUNCTION: May be involved in early neuronal development (By
CC       similarity). May play a role in promoting megakaryocyte differentiation
CC       (By similarity). {ECO:0000250|UniProtKB:Q7ZX36,
CC       ECO:0000250|UniProtKB:Q8N3F0}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8N3F0}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in embryo throughout the early nervous
CC       system. Strongly expressed in differentiating neurons in the brain,
CC       spinal cord and retina. Not detected in the lens at any developmental
CC       stage tested. {ECO:0000269|PubMed:24095902}.
CC   -!- SIMILARITY: Belongs to the MTURN family. {ECO:0000305}.
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DR   EMBL; CU424444; CAX13999.1; -; Genomic_DNA.
DR   RefSeq; NP_001138278.1; NM_001144806.1.
DR   AlphaFoldDB; P0C8M4; -.
DR   STRING; 7955.ENSDARP00000098753; -.
DR   PaxDb; P0C8M4; -.
DR   Ensembl; ENSDART00000108784; ENSDARP00000098753; ENSDARG00000074505.
DR   GeneID; 792465; -.
DR   KEGG; dre:792465; -.
DR   CTD; 222166; -.
DR   ZFIN; ZDB-GENE-081104-127; mturn.
DR   eggNOG; ENOG502RXQA; Eukaryota.
DR   GeneTree; ENSGT00500000045044; -.
DR   HOGENOM; CLU_163056_0_0_1; -.
DR   InParanoid; P0C8M4; -.
DR   OMA; YEQYHAD; -.
DR   OrthoDB; 1571561at2759; -.
DR   PhylomeDB; P0C8M4; -.
DR   TreeFam; TF332814; -.
DR   PRO; PR:P0C8M4; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 19.
DR   Bgee; ENSDARG00000074505; Expressed in retina and 5 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0045654; P:positive regulation of megakaryocyte differentiation; ISS:UniProtKB.
DR   GO; GO:0023051; P:regulation of signaling; IBA:GO_Central.
DR   InterPro; IPR027892; Maturin.
DR   PANTHER; PTHR32008; PTHR32008; 1.
DR   Pfam; PF15167; DUF4581; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; Reference proteome.
FT   CHAIN           1..133
FT                   /note="Maturin"
FT                   /id="PRO_0000359897"
SQ   SEQUENCE   133 AA;  15289 MW;  26BF254C616B5B13 CRC64;
     MEFKELVDAA EKWCTGNPFD LIFAEDVDER RLDFYAEPGI SFYVLCPDNL TGGTDNFHVW
     SESEDCLPFL QLAQDYISSC GKKTLLEVLD KVFRSFRPLL GLPDIDDDTF DQYHADVEEE
     PEPDHQQMGV SQQ