ID   MTURN_MOUSE             Reviewed;         131 AA.
AC   Q8CGA4;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Maturin;
DE   AltName: Full=Maturin neural progenitor differentiation regulator protein homolog;
GN   Name=Mturn;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J, and FVB/N; TISSUE=Brain, and Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, and Kidney;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [3]
RP   DEVELOPMENTAL STAGE.
RX   PubMed=24095902; DOI=10.1016/j.ydbio.2013.09.028;
RA   Martinez-De Luna R.I., Ku R.Y., Lyou Y., Zuber M.E.;
RT   "Maturin is a novel protein required for differentiation during primary
RT   neurogenesis.";
RL   Dev. Biol. 384:26-40(2013).
RN   [4]
RP   FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=24681962; DOI=10.1038/bcj.2014.18;
RA   Sun X., Lu B., Hu B., Xiao W., Li W., Huang Z.;
RT   "Novel function of the chromosome 7 open reading frame 41 gene to promote
RT   leukemic megakaryocyte differentiation by modulating TPA-induced
RT   signaling.";
RL   Blood Cancer J. 4:E198-E198(2014).
CC   -!- FUNCTION: Promotes megakaryocyte differentiation by enhancing ERK and
CC       JNK signaling as well as up-regulating RUNX1 and FLI1 expression
CC       (PubMed:24681962). Represses NF-kappa-B transcriptional activity by
CC       inhibiting phosphorylation of RELA at 'Ser- 536' (By similarity). May
CC       be involved in early neuronal development (By similarity).
CC       {ECO:0000250|UniProtKB:Q7ZX36, ECO:0000269|PubMed:24681962}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8N3F0}.
CC   -!- TISSUE SPECIFICITY: Expressed in the thymus, bone marrow and spleen.
CC       {ECO:0000269|PubMed:24681962}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in embryo throughout the early nervous
CC       system. Strongly expressed in differentiating neurons in the brain,
CC       spinal cord and retina. Not detected in the lens at any developmental
CC       stage tested. {ECO:0000269|PubMed:24095902}.
CC   -!- PTM: Phosphorylation at Tyr-34 is essential for its ability to promote
CC       megakaryocyte differentiation. {ECO:0000250|UniProtKB:Q8N3F0}.
CC   -!- SIMILARITY: Belongs to the MTURN family. {ECO:0000305}.
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DR   EMBL; BC042507; AAH42507.1; -; mRNA.
DR   EMBL; BC052467; AAH52467.1; -; mRNA.
DR   CCDS; CCDS20158.2; -.
DR   RefSeq; NP_001276669.1; NM_001289740.1.
DR   RefSeq; NP_001276670.1; NM_001289741.1.
DR   AlphaFoldDB; Q8CGA4; -.
DR   STRING; 10090.ENSMUSP00000140358; -.
DR   iPTMnet; Q8CGA4; -.
DR   PhosphoSitePlus; Q8CGA4; -.
DR   MaxQB; Q8CGA4; -.
DR   PRIDE; Q8CGA4; -.
DR   ProteomicsDB; 287639; -.
DR   Antibodypedia; 35235; 8 antibodies from 7 providers.
DR   Ensembl; ENSMUST00000190641; ENSMUSP00000140586; ENSMUSG00000038065.
DR   GeneID; 68235; -.
DR   KEGG; mmu:68235; -.
DR   UCSC; uc009cad.2; mouse.
DR   CTD; 222166; -.
DR   MGI; MGI:1915485; Mturn.
DR   VEuPathDB; HostDB:ENSMUSG00000038065; -.
DR   eggNOG; ENOG502RXQA; Eukaryota.
DR   GeneTree; ENSGT00500000045044; -.
DR   HOGENOM; CLU_163056_0_0_1; -.
DR   InParanoid; Q8CGA4; -.
DR   OrthoDB; 1571561at2759; -.
DR   BioGRID-ORCS; 68235; 0 hits in 57 CRISPR screens.
DR   ChiTaRS; Mturn; mouse.
DR   PRO; PR:Q8CGA4; -.
DR   Proteomes; UP000000589; Chromosome 6.
DR   RNAct; Q8CGA4; protein.
DR   Bgee; ENSMUSG00000038065; Expressed in cortical plate and 216 other tissues.
DR   ExpressionAtlas; Q8CGA4; baseline and differential.
DR   Genevisible; Q8CGA4; MM.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0048666; P:neuron development; ISS:MGI.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; ISS:UniProtKB.
DR   GO; GO:0045654; P:positive regulation of megakaryocyte differentiation; IMP:UniProtKB.
DR   GO; GO:0023051; P:regulation of signaling; IBA:GO_Central.
DR   InterPro; IPR027892; Maturin.
DR   PANTHER; PTHR32008; PTHR32008; 1.
DR   Pfam; PF15167; DUF4581; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Developmental protein; Phosphoprotein; Reference proteome.
FT   CHAIN           1..131
FT                   /note="Maturin"
FT                   /id="PRO_0000294234"
FT   REGION          107..131
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         34
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8N3F0"
SQ   SEQUENCE   131 AA;  14841 MW;  D7424C3DBB06F0B1 CRC64;
     MDFQQLADVA EKWCSSTPFE LIAAEETERR MDFYADPGVS FYVLCPDNGC GDSFHVWSES
     EDCLPFLQLA QDYISSCGKK TLHEVLEKVF KSFRPLLGLP DADDDAFEEY SADVEEEEPE
     ADHPQMGVSQ Q