ID   MTURN_RAT               Reviewed;         131 AA.
AC   Q5XI20;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Maturin;
DE   AltName: Full=Maturin neural progenitor differentiation regulator protein homolog;
GN   Name=Mturn;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Promotes megakaryocyte differentiation by enhancing ERK and
CC       JNK signaling as well as up-regulating RUNX1 and FLI1 expression (By
CC       similarity). Represses NF-kappa-B transcriptional activity by
CC       inhibiting phosphorylation of RELA at 'Ser- 536' (By similarity). May
CC       be involved in early neuronal development (By similarity).
CC       {ECO:0000250|UniProtKB:Q7ZX36, ECO:0000250|UniProtKB:Q8N3F0}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8N3F0}.
CC   -!- PTM: Phosphorylation at Tyr-34 is essential for its ability to promote
CC       megakaryocyte differentiation. {ECO:0000250|UniProtKB:Q8N3F0}.
CC   -!- SIMILARITY: Belongs to the MTURN family. {ECO:0000305}.
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DR   EMBL; BC083875; AAH83875.1; -; mRNA.
DR   RefSeq; NP_001007646.1; NM_001007645.1.
DR   AlphaFoldDB; Q5XI20; -.
DR   BioGRID; 255540; 1.
DR   STRING; 10116.ENSRNOP00000013620; -.
DR   iPTMnet; Q5XI20; -.
DR   PhosphoSitePlus; Q5XI20; -.
DR   PaxDb; Q5XI20; -.
DR   GeneID; 297109; -.
DR   KEGG; rno:297109; -.
DR   UCSC; RGD:1549700; rat.
DR   CTD; 222166; -.
DR   RGD; 1549700; Mturn.
DR   VEuPathDB; HostDB:ENSRNOG00000010205; -.
DR   eggNOG; ENOG502RXQA; Eukaryota.
DR   HOGENOM; CLU_163056_0_0_1; -.
DR   InParanoid; Q5XI20; -.
DR   OMA; YEQYHAD; -.
DR   OrthoDB; 1571561at2759; -.
DR   PRO; PR:Q5XI20; -.
DR   Proteomes; UP000002494; Chromosome 4.
DR   Bgee; ENSRNOG00000010205; Expressed in stomach and 17 other tissues.
DR   Genevisible; Q5XI20; RN.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISO:RGD.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISO:RGD.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; ISO:RGD.
DR   GO; GO:0045654; P:positive regulation of megakaryocyte differentiation; ISS:UniProtKB.
DR   GO; GO:0023051; P:regulation of signaling; IBA:GO_Central.
DR   InterPro; IPR027892; Maturin.
DR   PANTHER; PTHR32008; PTHR32008; 1.
DR   Pfam; PF15167; DUF4581; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; Phosphoprotein; Reference proteome.
FT   CHAIN           1..131
FT                   /note="Maturin"
FT                   /id="PRO_0000294235"
FT   REGION          107..131
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         34
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8N3F0"
SQ   SEQUENCE   131 AA;  14832 MW;  C4DFFAF54B06F0B1 CRC64;
     MDFQQLADVA EKWCSSTPFE LIAAEETERR MDFYADPGVS FYVLCPDNGC GDSFHVWSES
     EDCLPFLQLA QDYISSCGKK TLQEVLEKVF KSFRPLLGLP DADDDAFEEY SADVEEEEPE
     ADHPQMGVSQ Q