ID   MTURN_XENLA             Reviewed;         131 AA.
AC   Q7ZX36; Q6GQZ4;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 45.
DE   RecName: Full=Maturin;
DE   AltName: Full=Maturin neural progenitor differentiation regulator protein;
GN   Name=mturn; Synonyms=C7orf41;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION, INDUCTION, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX   PubMed=24095902; DOI=10.1016/j.ydbio.2013.09.028;
RA   Martinez-De Luna R.I., Ku R.Y., Lyou Y., Zuber M.E.;
RT   "Maturin is a novel protein required for differentiation during primary
RT   neurogenesis.";
RL   Dev. Biol. 384:26-40(2013).
CC   -!- FUNCTION: Involved in early neuronal development; required for cell
CC       cycle exit and differentiation of primary neurons (By similarity).
CC       Cooperates synergistically with pak3 to promote primary neural
CC       differentiation within the neural plate (PubMed:24095902). May play a
CC       role in promoting megakaryocyte differentiation (By similarity).
CC       {ECO:0000250|UniProtKB:Q8N3F0, ECO:0000269|PubMed:24095902}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8N3F0}.
CC   -!- DEVELOPMENTAL STAGE: Maternally expressed. Expressed at the animal half
CC       during the blastula stage. Expressed in the central, posterior and
CC       anterior neural plate regions, including the eye field at stage 12.5.
CC       Expressed in the posterior neural plate at stage 15. Later on,
CC       expressed in the developing nervous system. Expressed through the eye
CC       vesicle at stage 20. Strongly expressed in differentiating primary
CC       neurons in the brain, spinal cord and retina from stages 24 to 31. Not
CC       detected in the lens at any developmental stages.
CC       {ECO:0000269|PubMed:24095902}.
CC   -!- INDUCTION: Up-regulated by the proneural transcription factors Neurog2,
CC       Neurod1 and Ebf3. {ECO:0000269|PubMed:24095902}.
CC   -!- DISRUPTION PHENOTYPE: Morpholino knockdown of the protein causes an
CC       accumulation of neuronal progenitor cells resulting in the neural plate
CC       expansion. {ECO:0000269|PubMed:24095902}.
CC   -!- SIMILARITY: Belongs to the MTURN family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC045253; AAH45253.1; -; mRNA.
DR   EMBL; BC071157; AAH71157.1; -; mRNA.
DR   RefSeq; NP_001079626.1; NM_001086157.1.
DR   RefSeq; NP_001085379.1; NM_001091910.1.
DR   AlphaFoldDB; Q7ZX36; -.
DR   DNASU; 379313; -.
DR   GeneID; 379313; -.
DR   GeneID; 443805; -.
DR   KEGG; xla:379313; -.
DR   CTD; 379313; -.
DR   Xenbase; XB-GENE-945490; mturn.S.
DR   OrthoDB; 1571561at2759; -.
DR   Proteomes; UP000186698; Chromosome 6S.
DR   Bgee; 379313; Expressed in brain and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0007406; P:negative regulation of neuroblast proliferation; IMP:UniProtKB.
DR   GO; GO:0021990; P:neural plate formation; IMP:UniProtKB.
DR   GO; GO:0048666; P:neuron development; IDA:MGI.
DR   GO; GO:0045654; P:positive regulation of megakaryocyte differentiation; ISS:UniProtKB.
DR   GO; GO:0045666; P:positive regulation of neuron differentiation; IDA:UniProtKB.
DR   InterPro; IPR027892; Maturin.
DR   PANTHER; PTHR32008; PTHR32008; 1.
DR   Pfam; PF15167; DUF4581; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cytoplasm; Developmental protein; Differentiation;
KW   Growth arrest; Reference proteome.
FT   CHAIN           1..131
FT                   /note="Maturin"
FT                   /id="PRO_0000294236"
FT   REGION          107..131
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        83
FT                   /note="H -> N (in Ref. 1; AAH71157)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   131 AA;  15038 MW;  3490D10F9E109041 CRC64;
     MDFQQLADVA DKWCSNTPFD LIATEETERR MDFYADPGVS FYVLCPESGC GDHFHVWSES
     EDCLPFLQLA QDYISSCGKK TLHEILEKVF KSFRPLLGLP DVDDDTFEEY NADVEEEEPE
     ADHQQMGVSQ Q