ID   MTURN_XENTR             Reviewed;         131 AA.
AC   Q66KJ5;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 2.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Maturin;
DE   AltName: Full=Maturin neural progenitor differentiation regulator protein;
GN   Name=mturn;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in early neuronal development; required for cell
CC       cycle exit and differentiation of primary neurons (By similarity).
CC       Cooperates synergistically with pak3 to promote primary neural
CC       differentiation within the neural plate (By similarity). May play a
CC       role in promoting megakaryocyte differentiation (By similarity).
CC       {ECO:0000250|UniProtKB:Q7ZX36, ECO:0000250|UniProtKB:Q8N3F0}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8N3F0}.
CC   -!- SIMILARITY: Belongs to the MTURN family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH80370.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC080370; AAH80370.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001007923.2; NM_001007922.2.
DR   AlphaFoldDB; Q66KJ5; -.
DR   STRING; 8364.ENSXETP00000047640; -.
DR   PaxDb; Q66KJ5; -.
DR   DNASU; 493304; -.
DR   GeneID; 493304; -.
DR   KEGG; xtr:493304; -.
DR   CTD; 222166; -.
DR   Xenbase; XB-GENE-945483; mturn.
DR   eggNOG; ENOG502RXQA; Eukaryota.
DR   HOGENOM; CLU_163056_0_0_1; -.
DR   InParanoid; Q66KJ5; -.
DR   OMA; QDYITSC; -.
DR   OrthoDB; 1571561at2759; -.
DR   PhylomeDB; Q66KJ5; -.
DR   TreeFam; TF332814; -.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   ExpressionAtlas; Q66KJ5; baseline.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0045654; P:positive regulation of megakaryocyte differentiation; ISS:UniProtKB.
DR   GO; GO:0023051; P:regulation of signaling; IBA:GO_Central.
DR   InterPro; IPR027892; Maturin.
DR   PANTHER; PTHR32008; PTHR32008; 1.
DR   Pfam; PF15167; DUF4581; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cytoplasm; Developmental protein; Differentiation;
KW   Growth arrest; Reference proteome.
FT   CHAIN           1..131
FT                   /note="Maturin"
FT                   /id="PRO_0000294237"
FT   REGION          107..131
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   131 AA;  15038 MW;  3490D10F9E109041 CRC64;
     MDFQQLADVA DKWCSNTPFD LIATEETERR MDFYADPGVS FYVLCPESGC GDHFHVWSES
     EDCLPFLQLA QDYISSCGKK TLHEILEKVF KSFRPLLGLP DVDDDTFEEY NADVEEEEPE
     ADHQQMGVSQ Q