MTUS1_PONAB
ID MTUS1_PONAB Reviewed; 1270 AA.
AC Q5R9I1;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 25-MAY-2022, entry version 63.
DE RecName: Full=Microtubule-associated tumor suppressor 1 homolog;
DE AltName: Full=Mitochondrial tumor suppressor 1 homolog;
GN Name=MTUS1;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Cooperates with AGTR2 to inhibit ERK2 activation and cell
CC proliferation. May be required for AGTR2 cell surface expression.
CC Together with PTPN6, induces UBE2V2 expression upon angiotensin-II
CC stimulation (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. Interacts with AGTR2. Interacts with PTPN6.
CC Associates with microtubules (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}. Golgi apparatus
CC {ECO:0000250}. Cell membrane {ECO:0000250}. Nucleus {ECO:0000250}.
CC Note=In neurons, translocates into the nucleus after treatment with
CC angiotensin-II. Localizes with the mitotic spindle during mitosis and
CC with the intercellular bridge during cytokinesis. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MTUS1 family. {ECO:0000305}.
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DR EMBL; CR859407; CAH91579.1; -; mRNA.
DR RefSeq; NP_001125928.1; NM_001132456.1.
DR AlphaFoldDB; Q5R9I1; -.
DR SMR; Q5R9I1; -.
DR STRING; 9601.ENSPPYP00000020603; -.
DR GeneID; 100172862; -.
DR KEGG; pon:100172862; -.
DR CTD; 57509; -.
DR eggNOG; ENOG502QPVG; Eukaryota.
DR InParanoid; Q5R9I1; -.
DR OrthoDB; 91479at2759; -.
DR Proteomes; UP000001595; Unplaced.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR InterPro; IPR029786; MTUS1.
DR PANTHER; PTHR24200:SF7; PTHR24200:SF7; 1.
PE 2: Evidence at transcript level;
KW Cell cycle; Cell membrane; Coiled coil; Golgi apparatus; Membrane;
KW Mitochondrion; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..1270
FT /note="Microtubule-associated tumor suppressor 1 homolog"
FT /id="PRO_0000305199"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 183..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 374..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 524..558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 592..622
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 701..816
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1237..1270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 940..1231
FT /evidence="ECO:0000255"
FT COMPBIAS 19..50
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 183..212
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..402
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 531..558
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 737..779
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 792..816
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1241..1270
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 186
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9ULD2"
FT MOD_RES 386
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5HZI1"
FT MOD_RES 399
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9ULD2"
FT MOD_RES 443
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9ULD2"
FT MOD_RES 629
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9ULD2"
FT MOD_RES 1203
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6IMY1"
FT MOD_RES 1224
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9ULD2"
FT MOD_RES 1245
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9ULD2"
FT MOD_RES 1255
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5HZI1"
FT MOD_RES 1259
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6IMY1"
FT MOD_RES 1261
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5HZI1"
FT MOD_RES 1264
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9ULD2"
FT MOD_RES 1268
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9ULD2"
SQ SEQUENCE 1270 AA; 141576 MW; 59CA71CCE6F4878F CRC64;
MTDDNSDDKI EDELQTFFTS DKDGNTHAYN PKSPPTQKSS ASSVNWNSAN PDDMVVDYET
DPAVVTGENI SLSLQGVEVF DHEKSSSDFT SKQVLDMHKD SICQSPALVG TEKPKYLQHS
CHSLEAVEVQ SVEPSLPFVW KPNDNLNCTG YSDALELNQT FDMTVDKVNC TFISHHAIRK
SQSFHTAGSL PPTGRRSGNT SSLSYSTWTS SHSDKMHARE TTYDRESFEN PQVTPSEAQD
TTYTAFSDVV MQSEVFVSDI GNQCPCSSGK VTSEYTDGSQ QRLVGEKETQ ALTPVSDGME
VPNDSALQEF FCLSHDESNS EPHSQSSYRH KEMGQNLRET VSYCLVDDER PLMVPAFDKS
EAQVLNPEHK VTETEDTQMV TKGKDSGTQN HTSELILSSP PGQKVGSSFG LTWDANDMVI
STDNTMCMST PVLEPTKVTF SVSPIEATEK CKKVEKGNRG LKNISNSKEA PVNLCKPSLG
KSTTKTNTPI GCKVRKTEII SYPRPNFRNV KAKVMSRPVL QSKDAALSKV TPRPQLTSAS
SPSSAISRQP TVLSRTPRSD LNADKKAEIL INKTHKQQFN KLITSQAVHV TTHSKNASHR
VPRTTSAVKS NQEDVDKASS SNSACETGSV SALFQKIKGI LPVKMESAEC LEMTYVPNID
RISPEKKGEK ENGTSMEKQE LKQEIMNETF EYGSLFLGSA SKTTTTSGRN ISKPDSCGLR
QIAAPKAKVG PPVSCLRRNS DNRNPSADRA VSPQRIRRVS SSGKPTSLKT AQSSWVNLPR
PLPKSKASLK SPALRRTGST PSIASTHSEL STYSNNSGNA TVIKYEEKPP KPAFQNGSSG
SFYLKPLVSR AHVHLLKTPP KGPSRKNLFT ALNAVEKSRQ KNPRSLCIQT QTAPDVLPPE
KTLELTQYKT KCENQSGFIL QLKQLLACGN TKSEALTVVI QHLLSEREEA LKQHKTLSQE
LVNLRGELVT ASTTCEKLEE ARNELQTAYE AFVQQHQAEK TERENRLKEF YTREYEKLRD
TYIEEAEKYK MQLQEQFDNL NAAHETSKLE IEASHSEKVE LLKKAYEASL SEIKKGHEME
KKSLEDLLSE KQESLEKQIS DLKSENDALN EKLKSEEQKR RAREKANLKN PQIMYLEQEL
ESLKAVLEIK NEKLHQQDIK LMKMEKLVDN NTALVDKLKR FQQENEELKA RMDKHMAISR
QLSTEQAVLQ ESLEKESKVN KRLSMENEEL LWKLHNGDLC SPKRSPTSSA IPFQSPRNSG
SFPSPSISPR
