MTUS2_HUMAN
ID MTUS2_HUMAN Reviewed; 1369 AA.
AC Q5JR59; A7E292; B4DF81; O94872; Q08E97; Q5JQR3; Q8N5E2;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 22-SEP-2009, sequence version 3.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Microtubule-associated tumor suppressor candidate 2;
DE AltName: Full=Cardiac zipper protein;
DE AltName: Full=Microtubule plus-end tracking protein TIP150;
DE Short=Tracking protein of 150 kDa;
GN Name=MTUS2; Synonyms=CAZIP, KIAA0774, TIP150;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=9872452; DOI=10.1093/dnares/5.5.277;
RA Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A.,
RA Kotani H., Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XI. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 5:277-286(1998).
RN [2]
RP SEQUENCE REVISION.
RA Ohara O., Suyama M., Nagase T., Ishikawa K., Kikuno R.;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057823; DOI=10.1038/nature02379;
RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA Rogers J., Ross M.T.;
RT "The DNA sequence and analysis of human chromosome 13.";
RL Nature 428:522-528(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC TISSUE=Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP TISSUE SPECIFICITY.
RX PubMed=19806667; DOI=10.1002/dvdy.22107;
RA Du Puy L., Beqqali A., Monshouwer-Kloots J., Haagsman H.P., Roelen B.A.,
RA Passier R.;
RT "CAZIP, a novel protein expressed in the developing heart and nervous
RT system.";
RL Dev. Dyn. 238:2903-2911(2009).
RN [7]
RP FUNCTION, INTERACTION WITH KIF2C AND MAPRE1, HOMODIMERIZATION, AND
RP SUBCELLULAR LOCATION.
RX PubMed=19543227; DOI=10.1038/embor.2009.94;
RA Jiang K., Wang J., Liu J., Ward T., Wordeman L., Davidson A., Wang F.,
RA Yao X.;
RT "TIP150 interacts with and targets MCAK at the microtubule plus ends.";
RL EMBO Rep. 10:857-865(2009).
CC -!- FUNCTION: Binds microtubules. Together with MAPRE1 may target the
CC microtubule depolymerase KIF2C to the plus-end of microtubules. May
CC regulate the dynamics of microtubules at their growing distal tip.
CC {ECO:0000269|PubMed:19543227}.
CC -!- SUBUNIT: Homodimer. Interacts with KIF2C and MAPRE1; the interaction is
CC direct and probably targets MTUS2 and KIF2C to microtubules.
CC {ECO:0000269|PubMed:19543227}.
CC -!- INTERACTION:
CC Q5JR59; Q8WTP8: AEN; NbExp=3; IntAct=EBI-742948, EBI-8637627;
CC Q5JR59; Q9UHB7: AFF4; NbExp=3; IntAct=EBI-742948, EBI-395282;
CC Q5JR59; Q9UHB7-2: AFF4; NbExp=3; IntAct=EBI-742948, EBI-10261324;
CC Q5JR59; P29972: AQP1; NbExp=3; IntAct=EBI-742948, EBI-745213;
CC Q5JR59; A8K571: BMP7; NbExp=3; IntAct=EBI-742948, EBI-10174327;
CC Q5JR59; Q13895: BYSL; NbExp=5; IntAct=EBI-742948, EBI-358049;
CC Q5JR59; Q9NX04: C1orf109; NbExp=3; IntAct=EBI-742948, EBI-8643161;
CC Q5JR59; Q8TAB5: C1orf216; NbExp=4; IntAct=EBI-742948, EBI-747505;
CC Q5JR59; Q0VAL7: C21orf58; NbExp=3; IntAct=EBI-742948, EBI-10226774;
CC Q5JR59; Q53TS8: C2CD6; NbExp=3; IntAct=EBI-742948, EBI-739879;
CC Q5JR59; Q7Z7H3: CATIP; NbExp=3; IntAct=EBI-742948, EBI-10258233;
CC Q5JR59; Q8NEC5: CATSPER1; NbExp=3; IntAct=EBI-742948, EBI-744545;
CC Q5JR59; Q9HC52: CBX8; NbExp=3; IntAct=EBI-742948, EBI-712912;
CC Q5JR59; Q8IYX3: CCDC116; NbExp=4; IntAct=EBI-742948, EBI-744311;
CC Q5JR59; Q8IYE0-2: CCDC146; NbExp=3; IntAct=EBI-742948, EBI-10247802;
CC Q5JR59; Q96LX7: CCDC17; NbExp=3; IntAct=EBI-742948, EBI-719840;
CC Q5JR59; Q9NVL8: CCDC198; NbExp=3; IntAct=EBI-742948, EBI-10238351;
CC Q5JR59; Q8IWA6: CCDC60; NbExp=4; IntAct=EBI-742948, EBI-10262147;
CC Q5JR59; Q8TD31-3: CCHCR1; NbExp=3; IntAct=EBI-742948, EBI-10175300;
CC Q5JR59; Q86Y33: CDC20B; NbExp=3; IntAct=EBI-742948, EBI-10260504;
CC Q5JR59; Q6P1J9: CDC73; NbExp=5; IntAct=EBI-742948, EBI-930143;
CC Q5JR59; Q07002: CDK18; NbExp=3; IntAct=EBI-742948, EBI-746238;
CC Q5JR59; Q15078: CDK5R1; NbExp=3; IntAct=EBI-742948, EBI-746189;
CC Q5JR59; Q8N619: CDK5R1; NbExp=3; IntAct=EBI-742948, EBI-10266998;
CC Q5JR59; Q8TAM4: CDK5R1; NbExp=3; IntAct=EBI-742948, EBI-10271838;
CC Q5JR59; Q8IVW4: CDKL3; NbExp=3; IntAct=EBI-742948, EBI-3919850;
CC Q5JR59; Q8IYX8: CEP57L1; NbExp=3; IntAct=EBI-742948, EBI-1104570;
CC Q5JR59; Q8IYX8-2: CEP57L1; NbExp=3; IntAct=EBI-742948, EBI-10181988;
CC Q5JR59; Q96GE4: CEP95; NbExp=3; IntAct=EBI-742948, EBI-372775;
CC Q5JR59; Q8TCT0: CERK; NbExp=3; IntAct=EBI-742948, EBI-10274247;
CC Q5JR59; Q14746-2: COG2; NbExp=3; IntAct=EBI-742948, EBI-10233912;
CC Q5JR59; Q02930-3: CREB5; NbExp=3; IntAct=EBI-742948, EBI-10192698;
CC Q5JR59; Q49AN0: CRY2; NbExp=3; IntAct=EBI-742948, EBI-2212355;
CC Q5JR59; Q9UBR2: CTSZ; NbExp=3; IntAct=EBI-742948, EBI-8636823;
CC Q5JR59; Q2TBE0: CWF19L2; NbExp=3; IntAct=EBI-742948, EBI-5453285;
CC Q5JR59; O14625: CXCL11; NbExp=3; IntAct=EBI-742948, EBI-2871971;
CC Q5JR59; A2VCK2: DCDC2B; NbExp=3; IntAct=EBI-742948, EBI-10173222;
CC Q5JR59; Q9UJW0: DCTN4; NbExp=4; IntAct=EBI-742948, EBI-2134033;
CC Q5JR59; Q15398: DLGAP5; NbExp=3; IntAct=EBI-742948, EBI-748280;
CC Q5JR59; Q9NQL9: DMRT3; NbExp=3; IntAct=EBI-742948, EBI-9679045;
CC Q5JR59; Q92608: DOCK2; NbExp=3; IntAct=EBI-742948, EBI-448771;
CC Q5JR59; O60941: DTNB; NbExp=3; IntAct=EBI-742948, EBI-740402;
CC Q5JR59; Q8NE31: FAM13C; NbExp=3; IntAct=EBI-742948, EBI-751248;
CC Q5JR59; Q3B820: FAM161A; NbExp=3; IntAct=EBI-742948, EBI-719941;
CC Q5JR59; Q5TZK3: FAM74A6; NbExp=3; IntAct=EBI-742948, EBI-10247271;
CC Q5JR59; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-742948, EBI-6658203;
CC Q5JR59; Q96D16: FBXL18; NbExp=3; IntAct=EBI-742948, EBI-744419;
CC Q5JR59; Q9NWN3: FBXO34; NbExp=3; IntAct=EBI-742948, EBI-719816;
CC Q5JR59; O94868: FCHSD2; NbExp=4; IntAct=EBI-742948, EBI-1215612;
CC Q5JR59; Q9BVV2: FNDC11; NbExp=3; IntAct=EBI-742948, EBI-744935;
CC Q5JR59; Q9H3Q3: GAL3ST2; NbExp=3; IntAct=EBI-742948, EBI-10306373;
CC Q5JR59; A4D1E9: GTPBP10; NbExp=3; IntAct=EBI-742948, EBI-5453796;
CC Q5JR59; Q96CS2: HAUS1; NbExp=3; IntAct=EBI-742948, EBI-2514791;
CC Q5JR59; P08631: HCK; NbExp=3; IntAct=EBI-742948, EBI-346340;
CC Q5JR59; P56524: HDAC4; NbExp=3; IntAct=EBI-742948, EBI-308629;
CC Q5JR59; Q03933-2: HSF2; NbExp=3; IntAct=EBI-742948, EBI-10223348;
CC Q5JR59; L7RT22: ITGB5; NbExp=3; IntAct=EBI-742948, EBI-10178729;
CC Q5JR59; Q92993: KAT5; NbExp=3; IntAct=EBI-742948, EBI-399080;
CC Q5JR59; Q99661: KIF2C; NbExp=4; IntAct=EBI-742948, EBI-1642317;
CC Q5JR59; Q96BZ8: LENG1; NbExp=3; IntAct=EBI-742948, EBI-726510;
CC Q5JR59; Q7Z4I7-5: LIMS2; NbExp=3; IntAct=EBI-742948, EBI-10257651;
CC Q5JR59; P25791: LMO2; NbExp=3; IntAct=EBI-742948, EBI-739696;
CC Q5JR59; Q8TBB1: LNX1; NbExp=4; IntAct=EBI-742948, EBI-739832;
CC Q5JR59; Q96L50: LRR1; NbExp=3; IntAct=EBI-742948, EBI-2510106;
CC Q5JR59; Q96S90: LYSMD1; NbExp=3; IntAct=EBI-742948, EBI-10293291;
CC Q5JR59; P43361: MAGEA8; NbExp=3; IntAct=EBI-742948, EBI-10182930;
CC Q5JR59; Q15691: MAPRE1; NbExp=7; IntAct=EBI-742948, EBI-1004115;
CC Q5JR59; Q6IPE9: MARK4; NbExp=3; IntAct=EBI-742948, EBI-10250211;
CC Q5JR59; P55081: MFAP1; NbExp=3; IntAct=EBI-742948, EBI-1048159;
CC Q5JR59; Q9Y217: MTMR6; NbExp=3; IntAct=EBI-742948, EBI-766064;
CC Q5JR59; Q9GZM8: NDEL1; NbExp=3; IntAct=EBI-742948, EBI-928842;
CC Q5JR59; Q9UHB4: NDOR1; NbExp=4; IntAct=EBI-742948, EBI-10249760;
CC Q5JR59; P18615: NELFE; NbExp=3; IntAct=EBI-742948, EBI-348444;
CC Q5JR59; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-742948, EBI-741158;
CC Q5JR59; Q8NFP7: NUDT10; NbExp=3; IntAct=EBI-742948, EBI-726826;
CC Q5JR59; Q14990: ODF1; NbExp=4; IntAct=EBI-742948, EBI-10234557;
CC Q5JR59; Q5VU43: PDE4DIP; NbExp=3; IntAct=EBI-742948, EBI-1105124;
CC Q5JR59; Q13526: PIN1; NbExp=3; IntAct=EBI-742948, EBI-714158;
CC Q5JR59; Q99959: PKP2; NbExp=5; IntAct=EBI-742948, EBI-702235;
CC Q5JR59; Q9NRQ2: PLSCR4; NbExp=5; IntAct=EBI-742948, EBI-769257;
CC Q5JR59; Q9Y2S7: POLDIP2; NbExp=3; IntAct=EBI-742948, EBI-713000;
CC Q5JR59; Q8WUT1: POLDIP3; NbExp=3; IntAct=EBI-742948, EBI-10276663;
CC Q5JR59; Q8NEY8: PPHLN1; NbExp=3; IntAct=EBI-742948, EBI-474076;
CC Q5JR59; Q6NYC8: PPP1R18; NbExp=3; IntAct=EBI-742948, EBI-2557469;
CC Q5JR59; Q13131: PRKAA1; NbExp=3; IntAct=EBI-742948, EBI-1181405;
CC Q5JR59; Q8WWY3: PRPF31; NbExp=3; IntAct=EBI-742948, EBI-1567797;
CC Q5JR59; P25786: PSMA1; NbExp=6; IntAct=EBI-742948, EBI-359352;
CC Q5JR59; Q8WUK0: PTPMT1; NbExp=3; IntAct=EBI-742948, EBI-7199479;
CC Q5JR59; Q8TBN0: RAB3IL1; NbExp=3; IntAct=EBI-742948, EBI-743796;
CC Q5JR59; P41220: RGS2; NbExp=3; IntAct=EBI-742948, EBI-712388;
CC Q5JR59; Q8TCX5: RHPN1; NbExp=4; IntAct=EBI-742948, EBI-746325;
CC Q5JR59; Q96HH0: ROBO3; NbExp=3; IntAct=EBI-742948, EBI-10288358;
CC Q5JR59; P27694: RPA1; NbExp=3; IntAct=EBI-742948, EBI-621389;
CC Q5JR59; P32969: RPL9P9; NbExp=3; IntAct=EBI-742948, EBI-358122;
CC Q5JR59; Q14D33: RTP5; NbExp=3; IntAct=EBI-742948, EBI-10217913;
CC Q5JR59; O95171: SCEL; NbExp=3; IntAct=EBI-742948, EBI-7543896;
CC Q5JR59; O00560: SDCBP; NbExp=3; IntAct=EBI-742948, EBI-727004;
CC Q5JR59; Q8WWX9: SELENOM; NbExp=3; IntAct=EBI-742948, EBI-10277687;
CC Q5JR59; Q9C0A6-2: SETD5; NbExp=3; IntAct=EBI-742948, EBI-10303449;
CC Q5JR59; Q9H788: SH2D4A; NbExp=3; IntAct=EBI-742948, EBI-747035;
CC Q5JR59; Q9H788-2: SH2D4A; NbExp=3; IntAct=EBI-742948, EBI-10308083;
CC Q5JR59; Q08AM8: SH3RF2; NbExp=3; IntAct=EBI-742948, EBI-10225873;
CC Q5JR59; Q9NUL5: SHFL; NbExp=3; IntAct=EBI-742948, EBI-10313866;
CC Q5JR59; Q9UHI7: SLC23A1; NbExp=3; IntAct=EBI-742948, EBI-1759386;
CC Q5JR59; P12236: SLC25A6; NbExp=4; IntAct=EBI-742948, EBI-356254;
CC Q5JR59; Q9GZT3: SLIRP; NbExp=3; IntAct=EBI-742948, EBI-1050793;
CC Q5JR59; Q969G3: SMARCE1; NbExp=3; IntAct=EBI-742948, EBI-455078;
CC Q5JR59; O95863: SNAI1; NbExp=3; IntAct=EBI-742948, EBI-1045459;
CC Q5JR59; P09012: SNRPA; NbExp=3; IntAct=EBI-742948, EBI-607085;
CC Q5JR59; P08579: SNRPB2; NbExp=3; IntAct=EBI-742948, EBI-1053651;
CC Q5JR59; Q13573: SNW1; NbExp=3; IntAct=EBI-742948, EBI-632715;
CC Q5JR59; Q6RVD6: SPATA8; NbExp=3; IntAct=EBI-742948, EBI-8635958;
CC Q5JR59; Q9UQ90: SPG7; NbExp=4; IntAct=EBI-742948, EBI-717201;
CC Q5JR59; O75716: STK16; NbExp=3; IntAct=EBI-742948, EBI-749295;
CC Q5JR59; Q5T7P8-2: SYT6; NbExp=3; IntAct=EBI-742948, EBI-10246152;
CC Q5JR59; Q15543: TAF13; NbExp=3; IntAct=EBI-742948, EBI-1026992;
CC Q5JR59; Q9BT49: THAP7; NbExp=3; IntAct=EBI-742948, EBI-741350;
CC Q5JR59; Q08117: TLE5; NbExp=3; IntAct=EBI-742948, EBI-717810;
CC Q5JR59; Q96S44: TP53RK; NbExp=3; IntAct=EBI-742948, EBI-739588;
CC Q5JR59; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-742948, EBI-5235829;
CC Q5JR59; Q3SY00: TSGA10IP; NbExp=4; IntAct=EBI-742948, EBI-10241197;
CC Q5JR59; Q63HK5: TSHZ3; NbExp=3; IntAct=EBI-742948, EBI-9053916;
CC Q5JR59; Q99757: TXN2; NbExp=3; IntAct=EBI-742948, EBI-2932492;
CC Q5JR59; O75604: USP2; NbExp=3; IntAct=EBI-742948, EBI-743272;
CC Q5JR59; Q9BTA9: WAC; NbExp=3; IntAct=EBI-742948, EBI-749118;
CC Q5JR59; Q9BTA9-2: WAC; NbExp=3; IntAct=EBI-742948, EBI-10298216;
CC Q5JR59; Q53FD0: ZC2HC1C; NbExp=4; IntAct=EBI-742948, EBI-740767;
CC Q5JR59; G3V1X1: ZFC3H1; NbExp=3; IntAct=EBI-742948, EBI-6448783;
CC Q5JR59; Q6ZN57: ZFP2; NbExp=3; IntAct=EBI-742948, EBI-7236323;
CC Q5JR59; Q9BQ24: ZFYVE21; NbExp=3; IntAct=EBI-742948, EBI-2849569;
CC Q5JR59; Q96NC0: ZMAT2; NbExp=3; IntAct=EBI-742948, EBI-2682299;
CC Q5JR59; P52737: ZNF136; NbExp=4; IntAct=EBI-742948, EBI-749129;
CC Q5JR59; P17024: ZNF20; NbExp=3; IntAct=EBI-742948, EBI-717634;
CC Q5JR59; Q9UNY5: ZNF232; NbExp=3; IntAct=EBI-742948, EBI-749023;
CC Q5JR59; P15622-3: ZNF250; NbExp=3; IntAct=EBI-742948, EBI-10177272;
CC Q5JR59; P17036: ZNF3; NbExp=3; IntAct=EBI-742948, EBI-1640965;
CC Q5JR59; Q86U76: ZNF3; NbExp=3; IntAct=EBI-742948, EBI-10258769;
CC Q5JR59; Q86UD4: ZNF329; NbExp=3; IntAct=EBI-742948, EBI-7233259;
CC Q5JR59; Q9Y3M9: ZNF337; NbExp=3; IntAct=EBI-742948, EBI-714987;
CC Q5JR59; Q86VK4: ZNF410; NbExp=3; IntAct=EBI-742948, EBI-720304;
CC Q5JR59; Q09FC8: ZNF415; NbExp=3; IntAct=EBI-742948, EBI-10226171;
CC Q5JR59; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-742948, EBI-740727;
CC Q5JR59; Q9BUY5: ZNF426; NbExp=3; IntAct=EBI-742948, EBI-743265;
CC Q5JR59; Q8NDP4: ZNF439; NbExp=4; IntAct=EBI-742948, EBI-747580;
CC Q5JR59; Q8IYI8: ZNF440; NbExp=3; IntAct=EBI-742948, EBI-726439;
CC Q5JR59; Q9ULM2: ZNF490; NbExp=5; IntAct=EBI-742948, EBI-1105370;
CC Q5JR59; Q7Z3I7: ZNF572; NbExp=6; IntAct=EBI-742948, EBI-10172590;
CC Q5JR59; Q9P0T4: ZNF581; NbExp=4; IntAct=EBI-742948, EBI-745520;
CC Q5JR59; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-742948, EBI-6427977;
CC Q5JR59; Q96NL3: ZNF599; NbExp=3; IntAct=EBI-742948, EBI-8653994;
CC Q5JR59; Q96SK3: ZNF607; NbExp=3; IntAct=EBI-742948, EBI-747175;
CC Q5JR59; Q9P2J8: ZNF624; NbExp=3; IntAct=EBI-742948, EBI-9116427;
CC Q5JR59; Q9BS34: ZNF670; NbExp=3; IntAct=EBI-742948, EBI-745276;
CC Q5JR59; A8K8V0: ZNF785; NbExp=4; IntAct=EBI-742948, EBI-3925400;
CC Q5JR59; Q08AG5: ZNF844; NbExp=3; IntAct=EBI-742948, EBI-10225757;
CC Q5JR59; O43309: ZSCAN12; NbExp=3; IntAct=EBI-742948, EBI-1210440;
CC Q5JR59; Q16670: ZSCAN26; NbExp=3; IntAct=EBI-742948, EBI-3920053;
CC Q5JR59; A8K8Y5; NbExp=3; IntAct=EBI-742948, EBI-10174635;
CC Q5JR59; Q6ZVW3; NbExp=3; IntAct=EBI-742948, EBI-10255586;
CC Q5JR59; Q9H6F0; NbExp=3; IntAct=EBI-742948, EBI-10307481;
CC Q5JR59; PRO_0000449631 [P0DTD1]: rep; Xeno; NbExp=3; IntAct=EBI-742948, EBI-25475920;
CC Q5JR59; PRO_0000449633 [P0DTD1]: rep; Xeno; NbExp=3; IntAct=EBI-742948, EBI-25492395;
CC Q5JR59-3; Q6UXT9: ABHD15; NbExp=3; IntAct=EBI-11522433, EBI-2824666;
CC Q5JR59-3; Q08AH1: ACSM1; NbExp=3; IntAct=EBI-11522433, EBI-2818055;
CC Q5JR59-3; A0A0S2Z3D6: AKT1; NbExp=3; IntAct=EBI-11522433, EBI-16430470;
CC Q5JR59-3; X5D778: ANKRD11; NbExp=3; IntAct=EBI-11522433, EBI-17183751;
CC Q5JR59-3; Q49AR9: ANKS1A; NbExp=3; IntAct=EBI-11522433, EBI-11954519;
CC Q5JR59-3; P29972: AQP1; NbExp=3; IntAct=EBI-11522433, EBI-745213;
CC Q5JR59-3; P40617: ARL4A; NbExp=3; IntAct=EBI-11522433, EBI-2875746;
CC Q5JR59-3; A0A0S2Z4M1: AXIN1; NbExp=3; IntAct=EBI-11522433, EBI-16429430;
CC Q5JR59-3; O15169: AXIN1; NbExp=3; IntAct=EBI-11522433, EBI-710484;
CC Q5JR59-3; Q9H503-2: BANF2; NbExp=3; IntAct=EBI-11522433, EBI-11977289;
CC Q5JR59-3; Q99728: BARD1; NbExp=3; IntAct=EBI-11522433, EBI-473181;
CC Q5JR59-3; Q9BXY8: BEX2; NbExp=3; IntAct=EBI-11522433, EBI-745073;
CC Q5JR59-3; Q13895: BYSL; NbExp=3; IntAct=EBI-11522433, EBI-358049;
CC Q5JR59-3; Q9H6X5-2: C19orf44; NbExp=3; IntAct=EBI-11522433, EBI-12061599;
CC Q5JR59-3; Q8TAB5: C1orf216; NbExp=3; IntAct=EBI-11522433, EBI-747505;
CC Q5JR59-3; Q0VAL7: C21orf58; NbExp=3; IntAct=EBI-11522433, EBI-10226774;
CC Q5JR59-3; P54284: CACNB3; NbExp=3; IntAct=EBI-11522433, EBI-1184651;
CC Q5JR59-3; Q9HC52: CBX8; NbExp=3; IntAct=EBI-11522433, EBI-712912;
CC Q5JR59-3; Q8IX12: CCAR1; NbExp=3; IntAct=EBI-11522433, EBI-356265;
CC Q5JR59-3; Q8IYX3: CCDC116; NbExp=3; IntAct=EBI-11522433, EBI-744311;
CC Q5JR59-3; Q96HB5: CCDC120; NbExp=3; IntAct=EBI-11522433, EBI-744556;
CC Q5JR59-3; Q8IYE0: CCDC146; NbExp=3; IntAct=EBI-11522433, EBI-10749669;
CC Q5JR59-3; Q8N715: CCDC185; NbExp=3; IntAct=EBI-11522433, EBI-740814;
CC Q5JR59-3; E9PSE9: CCDC198; NbExp=3; IntAct=EBI-11522433, EBI-11748295;
CC Q5JR59-3; Q16204: CCDC6; NbExp=4; IntAct=EBI-11522433, EBI-1045350;
CC Q5JR59-3; Q8TD31-3: CCHCR1; NbExp=3; IntAct=EBI-11522433, EBI-10175300;
CC Q5JR59-3; Q99459: CDC5L; NbExp=3; IntAct=EBI-11522433, EBI-374880;
CC Q5JR59-3; O00311: CDC7; NbExp=3; IntAct=EBI-11522433, EBI-374980;
CC Q5JR59-3; Q6P1J9: CDC73; NbExp=6; IntAct=EBI-11522433, EBI-930143;
CC Q5JR59-3; Q07002: CDK18; NbExp=3; IntAct=EBI-11522433, EBI-746238;
CC Q5JR59-3; Q8IVW4: CDKL3; NbExp=4; IntAct=EBI-11522433, EBI-3919850;
CC Q5JR59-3; P38936: CDKN1A; NbExp=3; IntAct=EBI-11522433, EBI-375077;
CC Q5JR59-3; P46527: CDKN1B; NbExp=3; IntAct=EBI-11522433, EBI-519280;
CC Q5JR59-3; Q96GE4: CEP95; NbExp=4; IntAct=EBI-11522433, EBI-372775;
CC Q5JR59-3; Q9UKJ5: CHIC2; NbExp=3; IntAct=EBI-11522433, EBI-741528;
CC Q5JR59-3; Q8NE01: CNNM3; NbExp=3; IntAct=EBI-11522433, EBI-741032;
CC Q5JR59-3; Q14746: COG2; NbExp=4; IntAct=EBI-11522433, EBI-389449;
CC Q5JR59-3; Q49AN0: CRY2; NbExp=5; IntAct=EBI-11522433, EBI-2212355;
CC Q5JR59-3; P09603: CSF1; NbExp=3; IntAct=EBI-11522433, EBI-2872294;
CC Q5JR59-3; Q2TBE0: CWF19L2; NbExp=3; IntAct=EBI-11522433, EBI-5453285;
CC Q5JR59-3; Q9NS75: CYSLTR2; NbExp=3; IntAct=EBI-11522433, EBI-3843579;
CC Q5JR59-3; O43602-2: DCX; NbExp=4; IntAct=EBI-11522433, EBI-14148644;
CC Q5JR59-3; P26196: DDX6; NbExp=4; IntAct=EBI-11522433, EBI-351257;
CC Q5JR59-3; Q96LJ7: DHRS1; NbExp=3; IntAct=EBI-11522433, EBI-746300;
CC Q5JR59-3; Q9Y2H0-1: DLGAP4; NbExp=3; IntAct=EBI-11522433, EBI-12000556;
CC Q5JR59-3; Q9NQL9: DMRT3; NbExp=3; IntAct=EBI-11522433, EBI-9679045;
CC Q5JR59-3; Q92608: DOCK2; NbExp=3; IntAct=EBI-11522433, EBI-448771;
CC Q5JR59-3; O60941-5: DTNB; NbExp=3; IntAct=EBI-11522433, EBI-11984733;
CC Q5JR59-3; Q08426: EHHADH; NbExp=3; IntAct=EBI-11522433, EBI-2339219;
CC Q5JR59-3; O15371: EIF3D; NbExp=3; IntAct=EBI-11522433, EBI-353818;
CC Q5JR59-3; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-11522433, EBI-744099;
CC Q5JR59-3; Q6UWV6: ENPP7; NbExp=3; IntAct=EBI-11522433, EBI-12047821;
CC Q5JR59-3; Q8IYI6: EXOC8; NbExp=3; IntAct=EBI-11522433, EBI-742102;
CC Q5JR59-3; O95990-4: FAM107A; NbExp=3; IntAct=EBI-11522433, EBI-11977223;
CC Q5JR59-3; Q9BQ89: FAM110A; NbExp=4; IntAct=EBI-11522433, EBI-1752811;
CC Q5JR59-3; Q9H5Z6-2: FAM124B; NbExp=4; IntAct=EBI-11522433, EBI-11986315;
CC Q5JR59-3; Q3B820: FAM161A; NbExp=5; IntAct=EBI-11522433, EBI-719941;
CC Q5JR59-3; Q96MY7: FAM161B; NbExp=3; IntAct=EBI-11522433, EBI-7225287;
CC Q5JR59-3; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-11522433, EBI-6658203;
CC Q5JR59-3; Q9NWN3: FBXO34; NbExp=4; IntAct=EBI-11522433, EBI-719816;
CC Q5JR59-3; Q969U6: FBXW5; NbExp=3; IntAct=EBI-11522433, EBI-741068;
CC Q5JR59-3; Q4VC44: FLYWCH1; NbExp=3; IntAct=EBI-11522433, EBI-719415;
CC Q5JR59-3; Q8TAE8: GADD45GIP1; NbExp=3; IntAct=EBI-11522433, EBI-372506;
CC Q5JR59-3; Q8NHY3: GAS2L2; NbExp=3; IntAct=EBI-11522433, EBI-7960826;
CC Q5JR59-3; P55040: GEM; NbExp=6; IntAct=EBI-11522433, EBI-744104;
CC Q5JR59-3; Q86UU5: GGN; NbExp=3; IntAct=EBI-11522433, EBI-10259069;
CC Q5JR59-3; Q9NVN8: GNL3L; NbExp=3; IntAct=EBI-11522433, EBI-746682;
CC Q5JR59-3; Q92917: GPKOW; NbExp=3; IntAct=EBI-11522433, EBI-746309;
CC Q5JR59-3; P09211: GSTP1; NbExp=3; IntAct=EBI-11522433, EBI-353467;
CC Q5JR59-3; Q9GZV7: HAPLN2; NbExp=3; IntAct=EBI-11522433, EBI-11956675;
CC Q5JR59-3; P02008: HBZ; NbExp=3; IntAct=EBI-11522433, EBI-719843;
CC Q5JR59-3; A0A024R8L2: hCG_1987119; NbExp=3; IntAct=EBI-11522433, EBI-14103818;
CC Q5JR59-3; P08631-2: HCK; NbExp=3; IntAct=EBI-11522433, EBI-9834454;
CC Q5JR59-3; P56524-2: HDAC4; NbExp=3; IntAct=EBI-11522433, EBI-11953488;
CC Q5JR59-3; P09067: HOXB5; NbExp=3; IntAct=EBI-11522433, EBI-3893317;
CC Q5JR59-3; P17482: HOXB9; NbExp=3; IntAct=EBI-11522433, EBI-745290;
CC Q5JR59-3; Q03933: HSF2; NbExp=3; IntAct=EBI-11522433, EBI-2556750;
CC Q5JR59-3; Q14773-3: ICAM4; NbExp=3; IntAct=EBI-11522433, EBI-10233928;
CC Q5JR59-3; Q14005-2: IL16; NbExp=3; IntAct=EBI-11522433, EBI-17178971;
CC Q5JR59-3; Q9C086: INO80B; NbExp=3; IntAct=EBI-11522433, EBI-715611;
CC Q5JR59-3; P16144-2: ITGB4; NbExp=3; IntAct=EBI-11522433, EBI-11051601;
CC Q5JR59-3; P18084: ITGB5; NbExp=3; IntAct=EBI-11522433, EBI-1223434;
CC Q5JR59-3; Q8N9B5-2: JMY; NbExp=3; IntAct=EBI-11522433, EBI-10268138;
CC Q5JR59-3; Q15040: JOSD1; NbExp=3; IntAct=EBI-11522433, EBI-2510602;
CC Q5JR59-3; O75564-2: JRK; NbExp=3; IntAct=EBI-11522433, EBI-17181882;
CC Q5JR59-3; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-11522433, EBI-2556193;
CC Q5JR59-3; Q92993: KAT5; NbExp=4; IntAct=EBI-11522433, EBI-399080;
CC Q5JR59-3; Q9BVG8-5: KIFC3; NbExp=5; IntAct=EBI-11522433, EBI-14069005;
CC Q5JR59-3; O95678: KRT75; NbExp=3; IntAct=EBI-11522433, EBI-2949715;
CC Q5JR59-3; Q01546: KRT76; NbExp=3; IntAct=EBI-11522433, EBI-2952745;
CC Q5JR59-3; Q96BZ8: LENG1; NbExp=3; IntAct=EBI-11522433, EBI-726510;
CC Q5JR59-3; Q8TAP4-4: LMO3; NbExp=3; IntAct=EBI-11522433, EBI-11742507;
CC Q5JR59-3; P61968: LMO4; NbExp=4; IntAct=EBI-11522433, EBI-2798728;
CC Q5JR59-3; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-11522433, EBI-739832;
CC Q5JR59-3; O95983-2: MBD3; NbExp=3; IntAct=EBI-11522433, EBI-11978579;
CC Q5JR59-3; Q9H7H0-2: METTL17; NbExp=3; IntAct=EBI-11522433, EBI-11098807;
CC Q5JR59-3; Q8IVT4: MGC50722; NbExp=3; IntAct=EBI-11522433, EBI-14086479;
CC Q5JR59-3; Q9BU76: MMTAG2; NbExp=3; IntAct=EBI-11522433, EBI-742459;
CC Q5JR59-3; P00540: MOS; NbExp=4; IntAct=EBI-11522433, EBI-1757866;
CC Q5JR59-3; Q9Y3B7: MRPL11; NbExp=5; IntAct=EBI-11522433, EBI-5453723;
CC Q5JR59-3; P52179-2: MYOM1; NbExp=3; IntAct=EBI-11522433, EBI-12010196;
CC Q5JR59-3; Q86VE0: MYPOP; NbExp=5; IntAct=EBI-11522433, EBI-2858213;
CC Q5JR59-3; Q9UHB4: NDOR1; NbExp=3; IntAct=EBI-11522433, EBI-10249760;
CC Q5JR59-3; I6L9F6: NEFL; NbExp=3; IntAct=EBI-11522433, EBI-10178578;
CC Q5JR59-3; Q5HYW2: NHSL2; NbExp=3; IntAct=EBI-11522433, EBI-2859639;
CC Q5JR59-3; Q96HA8: NTAQ1; NbExp=5; IntAct=EBI-11522433, EBI-741158;
CC Q5JR59-3; Q9UBU9: NXF1; NbExp=3; IntAct=EBI-11522433, EBI-398874;
CC Q5JR59-3; A5D8V7: ODAD3; NbExp=3; IntAct=EBI-11522433, EBI-8466445;
CC Q5JR59-3; Q9Y5E9: PCDHB14; NbExp=3; IntAct=EBI-11522433, EBI-10329013;
CC Q5JR59-3; Q17RL8: PDZD4; NbExp=3; IntAct=EBI-11522433, EBI-10239064;
CC Q5JR59-3; Q4G0R1: PIBF1; NbExp=3; IntAct=EBI-11522433, EBI-14066006;
CC Q5JR59-3; Q13526: PIN1; NbExp=3; IntAct=EBI-11522433, EBI-714158;
CC Q5JR59-3; Q16512: PKN1; NbExp=3; IntAct=EBI-11522433, EBI-602382;
CC Q5JR59-3; Q6P5Z2: PKN3; NbExp=3; IntAct=EBI-11522433, EBI-1384335;
CC Q5JR59-3; Q99959-2: PKP2; NbExp=6; IntAct=EBI-11522433, EBI-10987518;
CC Q5JR59-3; Q494U1-3: PLEKHN1; NbExp=3; IntAct=EBI-11522433, EBI-12014286;
CC Q5JR59-3; Q8WUT1: POLDIP3; NbExp=3; IntAct=EBI-11522433, EBI-10276663;
CC Q5JR59-3; Q6NYC8: PPP1R18; NbExp=3; IntAct=EBI-11522433, EBI-2557469;
CC Q5JR59-3; P54646: PRKAA2; NbExp=4; IntAct=EBI-11522433, EBI-1383852;
CC Q5JR59-3; Q99633: PRPF18; NbExp=3; IntAct=EBI-11522433, EBI-2798416;
CC Q5JR59-3; Q8WWY3: PRPF31; NbExp=6; IntAct=EBI-11522433, EBI-1567797;
CC Q5JR59-3; P0CG20: PRR35; NbExp=3; IntAct=EBI-11522433, EBI-11986293;
CC Q5JR59-3; P25786: PSMA1; NbExp=3; IntAct=EBI-11522433, EBI-359352;
CC Q5JR59-3; P20618: PSMB1; NbExp=3; IntAct=EBI-11522433, EBI-372273;
CC Q5JR59-3; O75127: PTCD1; NbExp=3; IntAct=EBI-11522433, EBI-2560233;
CC Q5JR59-3; Q13308: PTK7; NbExp=3; IntAct=EBI-11522433, EBI-2803245;
CC Q5JR59-3; Q8TBN0: RAB3IL1; NbExp=4; IntAct=EBI-11522433, EBI-743796;
CC Q5JR59-3; Q53GL6: RALY; NbExp=3; IntAct=EBI-11522433, EBI-9512693;
CC Q5JR59-3; Q86VV4: RANBP3L; NbExp=3; IntAct=EBI-11522433, EBI-12028066;
CC Q5JR59-3; P61224: RAP1B; NbExp=3; IntAct=EBI-11522433, EBI-358143;
CC Q5JR59-3; Q86YV0: RASAL3; NbExp=3; IntAct=EBI-11522433, EBI-3437896;
CC Q5JR59-3; Q9Y272: RASD1; NbExp=3; IntAct=EBI-11522433, EBI-740818;
CC Q5JR59-3; Q96IZ5: RBM41; NbExp=3; IntAct=EBI-11522433, EBI-740773;
CC Q5JR59-3; Q9P2K3-2: RCOR3; NbExp=4; IntAct=EBI-11522433, EBI-1504830;
CC Q5JR59-3; P41220: RGS2; NbExp=3; IntAct=EBI-11522433, EBI-712388;
CC Q5JR59-3; A0A0S2Z4G9: RNF6; NbExp=4; IntAct=EBI-11522433, EBI-16428950;
CC Q5JR59-3; P27694: RPA1; NbExp=3; IntAct=EBI-11522433, EBI-621389;
CC Q5JR59-3; Q86WX3: RPS19BP1; NbExp=3; IntAct=EBI-11522433, EBI-4479407;
CC Q5JR59-3; Q14D33: RTP5; NbExp=3; IntAct=EBI-11522433, EBI-10217913;
CC Q5JR59-3; Q9UPU9-3: SAMD4A; NbExp=3; IntAct=EBI-11522433, EBI-11986417;
CC Q5JR59-3; Q9BWG6: SCNM1; NbExp=7; IntAct=EBI-11522433, EBI-748391;
CC Q5JR59-3; O00560: SDCBP; NbExp=3; IntAct=EBI-11522433, EBI-727004;
CC Q5JR59-3; Q9H788: SH2D4A; NbExp=5; IntAct=EBI-11522433, EBI-747035;
CC Q5JR59-3; Q8TEC5: SH3RF2; NbExp=4; IntAct=EBI-11522433, EBI-2130111;
CC Q5JR59-3; Q9NUL5-4: SHFL; NbExp=3; IntAct=EBI-11522433, EBI-11955083;
CC Q5JR59-3; O76082: SLC22A5; NbExp=3; IntAct=EBI-11522433, EBI-9846338;
CC Q5JR59-3; Q86VD7: SLC25A42; NbExp=3; IntAct=EBI-11522433, EBI-6598313;
CC Q5JR59-3; Q6ZT89-3: SLC25A48; NbExp=3; IntAct=EBI-11522433, EBI-12065614;
CC Q5JR59-3; Q96GM5: SMARCD1; NbExp=3; IntAct=EBI-11522433, EBI-358489;
CC Q5JR59-3; Q969G3: SMARCE1; NbExp=3; IntAct=EBI-11522433, EBI-455078;
CC Q5JR59-3; Q9H0W8: SMG9; NbExp=3; IntAct=EBI-11522433, EBI-2872322;
CC Q5JR59-3; Q13573: SNW1; NbExp=3; IntAct=EBI-11522433, EBI-632715;
CC Q5JR59-3; Q6RVD6: SPATA8; NbExp=3; IntAct=EBI-11522433, EBI-8635958;
CC Q5JR59-3; Q9H0A9-2: SPATC1L; NbExp=3; IntAct=EBI-11522433, EBI-11995806;
CC Q5JR59-3; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-11522433, EBI-742688;
CC Q5JR59-3; Q9BSH4: TACO1; NbExp=3; IntAct=EBI-11522433, EBI-747797;
CC Q5JR59-3; Q15543: TAF13; NbExp=4; IntAct=EBI-11522433, EBI-1026992;
CC Q5JR59-3; Q9NU19: TBC1D22B; NbExp=4; IntAct=EBI-11522433, EBI-8787464;
CC Q5JR59-3; Q15560: TCEA2; NbExp=3; IntAct=EBI-11522433, EBI-710310;
CC Q5JR59-3; Q8N8B7-2: TCEANC; NbExp=3; IntAct=EBI-11522433, EBI-11955057;
CC Q5JR59-3; Q9BT92: TCHP; NbExp=3; IntAct=EBI-11522433, EBI-740781;
CC Q5JR59-3; A0A0S2Z4F2: TEAD4; NbExp=3; IntAct=EBI-11522433, EBI-16429215;
CC Q5JR59-3; Q15561: TEAD4; NbExp=6; IntAct=EBI-11522433, EBI-747736;
CC Q5JR59-3; Q96N21: TEPSIN; NbExp=3; IntAct=EBI-11522433, EBI-11139477;
CC Q5JR59-3; Q9BT49: THAP7; NbExp=6; IntAct=EBI-11522433, EBI-741350;
CC Q5JR59-3; Q08117-2: TLE5; NbExp=6; IntAct=EBI-11522433, EBI-11741437;
CC Q5JR59-3; Q96KP6: TNIP3; NbExp=3; IntAct=EBI-11522433, EBI-2509913;
CC Q5JR59-3; P19237: TNNI1; NbExp=3; IntAct=EBI-11522433, EBI-746692;
CC Q5JR59-3; Q14134: TRIM29; NbExp=3; IntAct=EBI-11522433, EBI-702370;
CC Q5JR59-3; Q3SY00: TSGA10IP; NbExp=4; IntAct=EBI-11522433, EBI-10241197;
CC Q5JR59-3; Q63HK5: TSHZ3; NbExp=3; IntAct=EBI-11522433, EBI-9053916;
CC Q5JR59-3; Q5W5X9-3: TTC23; NbExp=4; IntAct=EBI-11522433, EBI-9090990;
CC Q5JR59-3; Q6ZVT0-3: TTLL10; NbExp=3; IntAct=EBI-11522433, EBI-11979997;
CC Q5JR59-3; Q99757: TXN2; NbExp=3; IntAct=EBI-11522433, EBI-2932492;
CC Q5JR59-3; P0CB47: UBTFL1; NbExp=3; IntAct=EBI-11522433, EBI-17208936;
CC Q5JR59-3; O75604: USP2; NbExp=3; IntAct=EBI-11522433, EBI-743272;
CC Q5JR59-3; Q9UPT9-2: USP22; NbExp=3; IntAct=EBI-11522433, EBI-12074414;
CC Q5JR59-3; Q5TAP6: UTP14C; NbExp=3; IntAct=EBI-11522433, EBI-11737646;
CC Q5JR59-3; Q6EMK4: VASN; NbExp=3; IntAct=EBI-11522433, EBI-10249550;
CC Q5JR59-3; Q05516: ZBTB16; NbExp=3; IntAct=EBI-11522433, EBI-711925;
CC Q5JR59-3; Q9UFB7: ZBTB47; NbExp=3; IntAct=EBI-11522433, EBI-7781767;
CC Q5JR59-3; Q15911-2: ZFHX3; NbExp=3; IntAct=EBI-11522433, EBI-10237226;
CC Q5JR59-3; Q6P2D0: ZFP1; NbExp=3; IntAct=EBI-11522433, EBI-2555749;
CC Q5JR59-3; Q96NC0: ZMAT2; NbExp=3; IntAct=EBI-11522433, EBI-2682299;
CC Q5JR59-3; O75800: ZMYND10; NbExp=3; IntAct=EBI-11522433, EBI-747061;
CC Q5JR59-3; Q15973: ZNF124; NbExp=3; IntAct=EBI-11522433, EBI-2555767;
CC Q5JR59-3; P52737: ZNF136; NbExp=4; IntAct=EBI-11522433, EBI-749129;
CC Q5JR59-3; P17021: ZNF17; NbExp=3; IntAct=EBI-11522433, EBI-1105334;
CC Q5JR59-3; P17024: ZNF20; NbExp=3; IntAct=EBI-11522433, EBI-717634;
CC Q5JR59-3; P17027: ZNF23; NbExp=3; IntAct=EBI-11522433, EBI-5657766;
CC Q5JR59-3; Q9UIE0: ZNF230; NbExp=3; IntAct=EBI-11522433, EBI-1105361;
CC Q5JR59-3; Q9UNY5: ZNF232; NbExp=3; IntAct=EBI-11522433, EBI-749023;
CC Q5JR59-3; Q16600: ZNF239; NbExp=3; IntAct=EBI-11522433, EBI-8787052;
CC Q5JR59-3; Q14584: ZNF266; NbExp=4; IntAct=EBI-11522433, EBI-7115319;
CC Q5JR59-3; Q86UD4: ZNF329; NbExp=4; IntAct=EBI-11522433, EBI-7233259;
CC Q5JR59-3; P13682: ZNF35; NbExp=3; IntAct=EBI-11522433, EBI-11041653;
CC Q5JR59-3; Q9H9D4: ZNF408; NbExp=3; IntAct=EBI-11522433, EBI-347633;
CC Q5JR59-3; Q96IQ9: ZNF414; NbExp=3; IntAct=EBI-11522433, EBI-744257;
CC Q5JR59-3; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-11522433, EBI-740727;
CC Q5JR59-3; Q7Z4V0: ZNF438; NbExp=3; IntAct=EBI-11522433, EBI-11962468;
CC Q5JR59-3; Q8NDP4: ZNF439; NbExp=3; IntAct=EBI-11522433, EBI-747580;
CC Q5JR59-3; Q8IYI8: ZNF440; NbExp=3; IntAct=EBI-11522433, EBI-726439;
CC Q5JR59-3; Q96MX3: ZNF48; NbExp=3; IntAct=EBI-11522433, EBI-12006434;
CC Q5JR59-3; Q9ULM2: ZNF490; NbExp=3; IntAct=EBI-11522433, EBI-1105370;
CC Q5JR59-3; Q6ZNH5: ZNF497; NbExp=3; IntAct=EBI-11522433, EBI-10486136;
CC Q5JR59-3; Q96KM6: ZNF512B; NbExp=3; IntAct=EBI-11522433, EBI-1049952;
CC Q5JR59-3; Q8N988-2: ZNF557; NbExp=3; IntAct=EBI-11522433, EBI-10699005;
CC Q5JR59-3; Q8TBZ8: ZNF564; NbExp=4; IntAct=EBI-11522433, EBI-10273713;
CC Q5JR59-3; Q7Z3I7: ZNF572; NbExp=3; IntAct=EBI-11522433, EBI-10172590;
CC Q5JR59-3; Q9UK33: ZNF580; NbExp=3; IntAct=EBI-11522433, EBI-746277;
CC Q5JR59-3; Q96SQ5: ZNF587; NbExp=5; IntAct=EBI-11522433, EBI-6427977;
CC Q5JR59-3; Q6PF04: ZNF613; NbExp=3; IntAct=EBI-11522433, EBI-12062855;
CC Q5JR59-3; Q9P2J8: ZNF624; NbExp=6; IntAct=EBI-11522433, EBI-9116427;
CC Q5JR59-3; Q5T619: ZNF648; NbExp=3; IntAct=EBI-11522433, EBI-11985915;
CC Q5JR59-3; Q96BR6: ZNF669; NbExp=3; IntAct=EBI-11522433, EBI-12006574;
CC Q5JR59-3; Q9H7X3: ZNF696; NbExp=3; IntAct=EBI-11522433, EBI-11090299;
CC Q5JR59-3; P36508: ZNF76; NbExp=3; IntAct=EBI-11522433, EBI-7254550;
CC Q5JR59-3; Q96H86: ZNF764; NbExp=3; IntAct=EBI-11522433, EBI-745775;
CC Q5JR59-3; Q6NX45: ZNF774; NbExp=3; IntAct=EBI-11522433, EBI-10251462;
CC Q5JR59-3; Q96BV0: ZNF775; NbExp=3; IntAct=EBI-11522433, EBI-7149881;
CC Q5JR59-3; A8K8V0: ZNF785; NbExp=3; IntAct=EBI-11522433, EBI-3925400;
CC Q5JR59-3; Q3KQV3: ZNF792; NbExp=3; IntAct=EBI-11522433, EBI-10240849;
CC Q5JR59-3; Q96EG3: ZNF837; NbExp=3; IntAct=EBI-11522433, EBI-11962574;
CC Q5JR59-3; Q16670: ZSCAN26; NbExp=3; IntAct=EBI-11522433, EBI-3920053;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000269|PubMed:19543227}. Note=Associated with the microtubule
CC network at the growing distal tip (the plus-end) of microtubules.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q5JR59-2; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5JR59-3; Sequence=VSP_023541, VSP_023543;
CC Name=3;
CC IsoId=Q5JR59-4; Sequence=VSP_023540;
CC -!- TISSUE SPECIFICITY: Detected in embryonic stem cells differentiating to
CC cardiomyocytes. {ECO:0000269|PubMed:19806667}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the MTUS1 family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI50246.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAA34494.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB018317; BAA34494.2; ALT_INIT; mRNA.
DR EMBL; AK293970; BAG57342.1; -; mRNA.
DR EMBL; AL160255; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL596092; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL596114; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL607144; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC032481; AAH32481.1; -; mRNA.
DR EMBL; BC119654; AAI19655.1; -; mRNA.
DR EMBL; BC119655; AAI19656.1; -; mRNA.
DR EMBL; BC129985; AAI29986.1; -; mRNA.
DR EMBL; BC150245; AAI50246.1; ALT_INIT; mRNA.
DR CCDS; CCDS41874.1; -. [Q5JR59-3]
DR CCDS; CCDS45022.1; -. [Q5JR59-2]
DR RefSeq; NP_001028774.2; NM_001033602.2. [Q5JR59-2]
DR RefSeq; NP_056048.1; NM_015233.5. [Q5JR59-3]
DR AlphaFoldDB; Q5JR59; -.
DR SMR; Q5JR59; -.
DR BioGRID; 116880; 389.
DR IntAct; Q5JR59; 370.
DR MINT; Q5JR59; -.
DR STRING; 9606.ENSP00000483729; -.
DR iPTMnet; Q5JR59; -.
DR PhosphoSitePlus; Q5JR59; -.
DR BioMuta; MTUS2; -.
DR DMDM; 259016371; -.
DR EPD; Q5JR59; -.
DR MassIVE; Q5JR59; -.
DR MaxQB; Q5JR59; -.
DR PaxDb; Q5JR59; -.
DR PeptideAtlas; Q5JR59; -.
DR PRIDE; Q5JR59; -.
DR ProteomicsDB; 63070; -. [Q5JR59-2]
DR ProteomicsDB; 63071; -. [Q5JR59-3]
DR ProteomicsDB; 63072; -. [Q5JR59-4]
DR Antibodypedia; 22727; 93 antibodies from 24 providers.
DR DNASU; 23281; -.
DR Ensembl; ENST00000380808.6; ENSP00000370186.2; ENSG00000132938.22. [Q5JR59-3]
DR Ensembl; ENST00000542829.1; ENSP00000445403.1; ENSG00000132938.22. [Q5JR59-4]
DR Ensembl; ENST00000612955.6; ENSP00000483729.2; ENSG00000132938.22. [Q5JR59-2]
DR GeneID; 23281; -.
DR KEGG; hsa:23281; -.
DR MANE-Select; ENST00000612955.6; ENSP00000483729.2; NM_001033602.4; NP_001028774.3.
DR UCSC; uc001usm.5; human. [Q5JR59-2]
DR CTD; 23281; -.
DR DisGeNET; 23281; -.
DR GeneCards; MTUS2; -.
DR HGNC; HGNC:20595; MTUS2.
DR HPA; ENSG00000132938; Tissue enriched (heart).
DR MIM; 619358; gene.
DR neXtProt; NX_Q5JR59; -.
DR OpenTargets; ENSG00000132938; -.
DR PharmGKB; PA165505194; -.
DR VEuPathDB; HostDB:ENSG00000132938; -.
DR eggNOG; ENOG502QQFP; Eukaryota.
DR GeneTree; ENSGT00950000183026; -.
DR HOGENOM; CLU_029786_0_0_1; -.
DR InParanoid; Q5JR59; -.
DR OMA; NTCQQKI; -.
DR OrthoDB; 818881at2759; -.
DR PhylomeDB; Q5JR59; -.
DR PathwayCommons; Q5JR59; -.
DR SignaLink; Q5JR59; -.
DR BioGRID-ORCS; 23281; 8 hits in 1067 CRISPR screens.
DR ChiTaRS; MTUS2; human.
DR GenomeRNAi; 23281; -.
DR Pharos; Q5JR59; Tbio.
DR PRO; PR:Q5JR59; -.
DR Proteomes; UP000005640; Chromosome 13.
DR RNAct; Q5JR59; protein.
DR Bgee; ENSG00000132938; Expressed in heart right ventricle and 139 other tissues.
DR Genevisible; Q5JR59; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0045171; C:intercellular bridge; IDA:HPA.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0015630; C:microtubule cytoskeleton; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IDA:CACAO.
DR GO; GO:0008017; F:microtubule binding; IDA:UniProtKB.
DR GO; GO:0042803; F:protein homodimerization activity; IPI:UniProtKB.
DR InterPro; IPR033339; MTUS2.
DR PANTHER; PTHR24200:SF14; PTHR24200:SF14; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Cytoplasm; Cytoskeleton; Microtubule;
KW Reference proteome.
FT CHAIN 1..1369
FT /note="Microtubule-associated tumor suppressor candidate 2"
FT /id="PRO_0000280111"
FT REGION 180..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 374..442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 477..509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 582..627
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 641..980
FT /note="Mediates interaction with MAPRE1"
FT /evidence="ECO:0000269|PubMed:19543227"
FT REGION 791..839
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 801..1150
FT /note="Localization to the growing distal tip of
FT microtubules"
FT REGION 801..890
FT /note="Sufficient for interaction with KIF2C"
FT /evidence="ECO:0000269|PubMed:19543227"
FT REGION 861..992
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1331..1369
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 991..1335
FT /evidence="ECO:0000255"
FT COMPBIAS 182..198
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 247..262
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 388..409
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 422..442
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 791..831
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 861..890
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 916..938
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 947..969
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..1111
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_023540"
FT VAR_SEQ 1..1021
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_023541"
FT VAR_SEQ 1022..1039
FT /note="AICGFDALAVATQHFFRK -> MGHCCCKPYNCLQCLDKT (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_023543"
FT VARIANT 955
FT /note="P -> H (in dbSNP:rs12874207)"
FT /id="VAR_055941"
FT VARIANT 1071
FT /note="L -> Q (in dbSNP:rs17073511)"
FT /id="VAR_058831"
FT CONFLICT 942
FT /note="Q -> P (in Ref. 1; BAA34494 and 5; AAI50246)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1369 AA; 150195 MW; 4BF7A754AB1ED7CF CRC64;
MSVPVAPKKS CYTQLRDNRN AARNNNESIL SLGDTNANQI MLEVSSSHDE SKTCDLGDEI
GNTNSSEPEN RTHFHKEFHQ LQGFGKGSQA GSASLKDFRL SSTIQRELNE EHTVERGTDS
LQTTRSIQGP SLSSWRNVMS EASLDVLAKR DAEIPRHVPK DKLAKTLDNE ELRRHSLERA
SSSVAAVGSL TPQHPQPLSL DSREARGQIP GGGEGPQKTL PDHAVPAAFP ATDSTSEGKS
VRHPKPSTSE SKQSTPSETQ TVGAHVLQVC SEHTSHSAHP EPALNLTLAS KEIPSKLEAQ
LGQGKGEAKL DLKYVPPRRV EQEGKAAQEG YLGCHKEENL SALEGRDPCG EAHPEATDAL
GHLLNSDLHH LGVGRGNCEE KRGVNPGEQD SLHTTPKQGS ASLGGADNQP TGKISPCAGE
KLGERTSSSF SPGDSHVAFI PNNLTDSKPL DVIEEERRLG SGNKDSVMVL VFNPSVGENK
TEVPEPLDPQ SGRSEARESK EVTTSVAENR NLLENADKIE STSARADSVL NIPAPLHPET
TVNMTYQPTT PSSSFQDVSV FGMDAGSPLV VPPPTDSARL LNTSPKVPDK NTCPSGIPKP
VFTHSKDTPS SQEGMENYQV EKTEERTETK PIIMPKPKHV RPKIITYIRR NPQALGQVDA
SLVPVGLPYA PPTCTMPLPH EEKAAGGDLK PSANLYEKFK PDLQKPRVFS SGLMVSGIKP
PGHPFSQMSE KFLQEVTDHP GKEEFCSPPY AHYEVPPTFY RSAMLLKPQL GLGAMSRLPS
AKSRILIASQ RSSASAIHPP GPITTATSLY SSDPSADLKK ASSSNAAKSN LPKSGLRPPG
YSRLPAAKLA AFGFVRSSSV SSVSSTQSGD SAQPEQGRPA TRSTFGNEEQ PVLKASLPSK
DTPKGAGRVA PPASSSVTAP RRSLLPAPKS TSTPAGTKKD AQKDQDTNKP AVSSPKRVAA
STTKLHSPGY PKQRTAAARN GFPPKPDPQA REAERQLVLR LKERCEQQTR QLGVAQGELK
RAICGFDALA VATQHFFRKN ESALVKEKEL SIELANIRDE VAFHTAKCEK LQKEKEELER
RFEDEVKRLG WQQQAELQEL EERLQLQFEA EMARLQEEHG DQLLSIRCQH QEQVEDLTAS
HDAALLEMEN NHTVAITILQ DDHDHKVQEL MSTHELEKKE LEENFEKLRL SLQDQVDTLT
FQSQSLRDRA RRFEEALRKN TEEQLEIALA PYQHLEEDMK SLKQVLEMKN QQIHEQEKKI
LELEKLAEKN IILEEKIQVL QQQNEDLKAR IDQNTVVTRQ LSEENANLQE YVEKETQEKK
RLSRTNEELL WKLQTGDPTS PIKLSPTSPV YRGSSSGPSS PARVSTTPR
