MTX1_BOVIN
ID MTX1_BOVIN Reviewed; 317 AA.
AC Q2TBS1;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 1.
DT 25-MAY-2022, entry version 90.
DE RecName: Full=Metaxin-1;
DE AltName: Full=Mitochondrial outer membrane import complex protein 1;
GN Name=MTX1;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in transport of proteins into the mitochondrion.
CC Essential for embryonic development (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with MTX2/metaxin-2 (By similarity). Associates with
CC the mitochondrial contact site and cristae organizing system (MICOS)
CC complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19,
CC CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13
CC (By similarity). This complex was also known under the names MINOS or
CC MitOS complex (By similarity). The MICOS complex associates with
CC mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together
CC described as components of the mitochondrial outer membrane sorting
CC assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner
CC membrane protein TMEM11 and with HSPA9 (By similarity). The MICOS and
CC SAM complexes together with DNAJC11 are part of a large protein complex
CC spanning both membranes termed the mitochondrial intermembrane space
CC bridging (MIB) complex (By similarity). Interacts with ARMC1 (By
CC similarity). {ECO:0000250|UniProtKB:Q13505}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250}.
CC -!- PTM: Ubiquitinated by PRKN during mitophagy, leading to its degradation
CC and enhancement of mitophagy. Deubiquitinated by USP30.
CC {ECO:0000250|UniProtKB:Q13505}.
CC -!- SIMILARITY: Belongs to the metaxin family. {ECO:0000305}.
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DR EMBL; BC109736; AAI09737.1; -; mRNA.
DR RefSeq; NP_001035698.1; NM_001040608.2.
DR AlphaFoldDB; Q2TBS1; -.
DR SMR; Q2TBS1; -.
DR STRING; 9913.ENSBTAP00000019763; -.
DR PaxDb; Q2TBS1; -.
DR GeneID; 664655; -.
DR KEGG; bta:664655; -.
DR CTD; 4580; -.
DR eggNOG; KOG3028; Eukaryota.
DR InParanoid; Q2TBS1; -.
DR OrthoDB; 1472286at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0001401; C:SAM complex; IBA:GO_Central.
DR GO; GO:0007005; P:mitochondrion organization; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR040079; Glutathione_S-Trfase.
DR InterPro; IPR017410; Metaxin1/3.
DR InterPro; IPR033468; Metaxin_GST.
DR InterPro; IPR019564; Sam37/metaxin_N.
DR Pfam; PF17171; GST_C_6; 1.
DR Pfam; PF10568; Tom37; 1.
DR PIRSF; PIRSF038150; Metaxin; 1.
DR SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR SUPFAM; SSF47616; SSF47616; 1.
PE 2: Evidence at transcript level;
KW Isopeptide bond; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW Protein transport; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport; Ubl conjugation.
FT CHAIN 1..317
FT /note="Metaxin-1"
FT /id="PRO_0000320055"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CROSSLNK 38
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in ubiquitin)"
FT /evidence="ECO:0000250|UniProtKB:Q13505"
FT CROSSLNK 41
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in ubiquitin)"
FT /evidence="ECO:0000250|UniProtKB:Q13505"
FT CROSSLNK 78
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in ubiquitin)"
FT /evidence="ECO:0000250|UniProtKB:Q13505"
SQ SEQUENCE 317 AA; 35674 MW; 2B9F26D21559047E CRC64;
MAAPMELFCW SGGWGLPSVD LDSLAVLTYA RFTGAPLKVH KITNPWRSPS GTLPALRTSH
GEVISVPHRI ITHLRKEKYN ADYDLSARQG ADTLAFMSLL EEKLLPVLKH TFWIDAKNYV
EVTRKWYAEA MPFPLNFFLP GRMQRQYMER LQLLCGEHRP EDEEELEKEL YQEAQECLTL
LSQRLGSQKF FFGDAPASLD AFVFSYLALL QQAKLPSGKL QAHLRGLHNL CAYCAHILSL
YFPWEGAKAP PPRQTPANPE TEEEPYRRRN QILTVLAGLA AMAGYALLSG IVSIQRAPSA
RAPGTQALGM AEEDEEE