MTX1_CAEBR
ID MTX1_CAEBR Reviewed; 312 AA.
AC A8XWD1;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 1.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Metaxin-1 homolog {ECO:0000250|UniProtKB:O45503};
DE AltName: Full=Mitochondrial outer membrane import complex protein 1;
GN Name=mtx-1 {ECO:0000312|EMBL:CAP36950.1}; ORFNames=CBG19767;
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238;
RN [1] {ECO:0000312|EMBL:CAP36950.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16 {ECO:0000312|EMBL:CAP36950.1};
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R.M., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- FUNCTION: Involved in transport of proteins into the mitochondrion.
CC Essential for embryonic development (By similarity).
CC {ECO:0000250|UniProtKB:P47802}.
CC -!- SUBUNIT: Associates with the mitochondrial contact site and cristae
CC organizing system (MICOS) complex (also known as MINOS or MitOS
CC complex). {ECO:0000250|UniProtKB:Q13505}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC {ECO:0000250|UniProtKB:P47802}.
CC -!- SIMILARITY: Belongs to the metaxin family. {ECO:0000255}.
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DR EMBL; HE601474; CAP36950.1; -; Genomic_DNA.
DR RefSeq; XP_002640701.1; XM_002640655.1.
DR AlphaFoldDB; A8XWD1; -.
DR SMR; A8XWD1; -.
DR STRING; 6238.CBG19767; -.
DR EnsemblMetazoa; CBG19767.1; CBG19767.1; WBGene00038933.
DR GeneID; 8582696; -.
DR KEGG; cbr:CBG_19767; -.
DR CTD; 8582696; -.
DR WormBase; CBG19767; CBP04636; WBGene00038933; Cbr-mtx-1.
DR eggNOG; KOG3028; Eukaryota.
DR HOGENOM; CLU_044137_5_0_1; -.
DR InParanoid; A8XWD1; -.
DR OMA; IWPSDFG; -.
DR OrthoDB; 1472286at2759; -.
DR Proteomes; UP000008549; Chromosome I.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0001401; C:SAM complex; IBA:GO_Central.
DR GO; GO:0007005; P:mitochondrion organization; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR017410; Metaxin1/3.
DR InterPro; IPR033468; Metaxin_GST.
DR InterPro; IPR019564; Sam37/metaxin_N.
DR Pfam; PF17171; GST_C_6; 1.
DR Pfam; PF10568; Tom37; 1.
DR PIRSF; PIRSF038150; Metaxin; 1.
DR SUPFAM; SSF47616; SSF47616; 1.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion outer membrane; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..312
FT /note="Metaxin-1 homolog"
FT /id="PRO_0000367042"
FT TRANSMEM 282..302
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 312 AA; 35141 MW; 7F60C3B048FCFFE3 CRC64;
MELHIWPSDF GLPTIDVSSL QFLACSKMCA SPVRVVQSAR PWRSPNGELP MVAQIDGNAK
PVTDFEKFVD ILKKCGQDVV IDADLTTIER AQLDAFSCYL HHNLYPAVLH TFWADDLNYN
TVTQYWYASH LHFPYNLYYL EKRKKKALRM LGGKNDTEIL KDAFMALNTL STKLGDNKFF
CGNKPTSLDA LVFGYLAPLL RVPLPNDRLQ VQLSACPNLV RFVETVSSIY LPLSEDELKR
QQSNRKMWQS RISKAKADKE AAKTTEEAAE AIPDEPPMRD AILFTIGALV LSVAFAIHTG
LIQVSVEEEI AE
