MTX1_CAEEL
ID MTX1_CAEEL Reviewed; 312 AA.
AC O45503;
DT 21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Metaxin-1 homolog;
DE AltName: Full=Mitochondrial outer membrane import complex protein 1;
GN Name=mtx-1; ORFNames=F39B2.11;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Involved in transport of proteins into the mitochondrion.
CC Essential for embryonic development (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Associates with the mitochondrial contact site and cristae
CC organizing system (MICOS) complex (also known as MINOS or MitOS
CC complex). {ECO:0000250|UniProtKB:Q13505}.
CC -!- INTERACTION:
CC O45503; Q21746: sgt-1; NbExp=3; IntAct=EBI-317069, EBI-312019;
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the metaxin family. {ECO:0000305}.
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DR EMBL; Z92834; CAB07391.1; -; Genomic_DNA.
DR PIR; T21992; T21992.
DR RefSeq; NP_493569.1; NM_061168.5.
DR AlphaFoldDB; O45503; -.
DR SMR; O45503; -.
DR BioGRID; 38725; 4.
DR DIP; DIP-24341N; -.
DR IntAct; O45503; 1.
DR STRING; 6239.F39B2.11; -.
DR EPD; O45503; -.
DR PaxDb; O45503; -.
DR PeptideAtlas; O45503; -.
DR EnsemblMetazoa; F39B2.11.1; F39B2.11.1; WBGene00009559.
DR GeneID; 173340; -.
DR KEGG; cel:CELE_F39B2.11; -.
DR CTD; 173340; -.
DR WormBase; F39B2.11; CE16016; WBGene00009559; mtx-1.
DR eggNOG; KOG3028; Eukaryota.
DR GeneTree; ENSGT00950000182919; -.
DR HOGENOM; CLU_044137_5_0_1; -.
DR InParanoid; O45503; -.
DR OMA; IWPSDFG; -.
DR OrthoDB; 1472286at2759; -.
DR PhylomeDB; O45503; -.
DR PRO; PR:O45503; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00009559; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0001401; C:SAM complex; IBA:GO_Central.
DR GO; GO:0007005; P:mitochondrion organization; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR017410; Metaxin1/3.
DR InterPro; IPR033468; Metaxin_GST.
DR InterPro; IPR019564; Sam37/metaxin_N.
DR Pfam; PF17171; GST_C_6; 1.
DR Pfam; PF10568; Tom37; 1.
DR PIRSF; PIRSF038150; Metaxin; 1.
DR SUPFAM; SSF47616; SSF47616; 1.
PE 1: Evidence at protein level;
KW Membrane; Mitochondrion; Mitochondrion outer membrane; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..312
FT /note="Metaxin-1 homolog"
FT /id="PRO_0000220993"
FT TRANSMEM 282..302
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 312 AA; 35320 MW; C870D8BCE4CB7EB3 CRC64;
MELHIWPSDF GLPTIDVVSL QFLACSKMCA SPVRVIQSTR PWRSPSGELP MVAQTEGEAK
PVTDFEKFVD ILKKCGQDVV IDADLTTIEK AQLDAFSCYL HHNLYPAVMH TFWTDELNYN
TVTQYWYASH LHFPYNLYYL EKRRKKALRL LAGKNDTEIL KEAFMALNTL STKLGDNKFF
CGNKPTSLDA LVFGYLAPLL RVPLPNDRLQ VQLSACPNLV RFVETVSSIY LPLGEDELKR
QQANRKMWQS RISKAKADKE AAKTTEEASE SLPEEPPMRD AILFTLGALT LSLVFAIHTG
LIQVSVEEEI SE