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MTX1_CAEEL
ID   MTX1_CAEEL              Reviewed;         312 AA.
AC   O45503;
DT   21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 147.
DE   RecName: Full=Metaxin-1 homolog;
DE   AltName: Full=Mitochondrial outer membrane import complex protein 1;
GN   Name=mtx-1; ORFNames=F39B2.11;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Involved in transport of proteins into the mitochondrion.
CC       Essential for embryonic development (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Associates with the mitochondrial contact site and cristae
CC       organizing system (MICOS) complex (also known as MINOS or MitOS
CC       complex). {ECO:0000250|UniProtKB:Q13505}.
CC   -!- INTERACTION:
CC       O45503; Q21746: sgt-1; NbExp=3; IntAct=EBI-317069, EBI-312019;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the metaxin family. {ECO:0000305}.
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DR   EMBL; Z92834; CAB07391.1; -; Genomic_DNA.
DR   PIR; T21992; T21992.
DR   RefSeq; NP_493569.1; NM_061168.5.
DR   AlphaFoldDB; O45503; -.
DR   SMR; O45503; -.
DR   BioGRID; 38725; 4.
DR   DIP; DIP-24341N; -.
DR   IntAct; O45503; 1.
DR   STRING; 6239.F39B2.11; -.
DR   EPD; O45503; -.
DR   PaxDb; O45503; -.
DR   PeptideAtlas; O45503; -.
DR   EnsemblMetazoa; F39B2.11.1; F39B2.11.1; WBGene00009559.
DR   GeneID; 173340; -.
DR   KEGG; cel:CELE_F39B2.11; -.
DR   CTD; 173340; -.
DR   WormBase; F39B2.11; CE16016; WBGene00009559; mtx-1.
DR   eggNOG; KOG3028; Eukaryota.
DR   GeneTree; ENSGT00950000182919; -.
DR   HOGENOM; CLU_044137_5_0_1; -.
DR   InParanoid; O45503; -.
DR   OMA; IWPSDFG; -.
DR   OrthoDB; 1472286at2759; -.
DR   PhylomeDB; O45503; -.
DR   PRO; PR:O45503; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00009559; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0001401; C:SAM complex; IBA:GO_Central.
DR   GO; GO:0007005; P:mitochondrion organization; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR   InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR   InterPro; IPR017410; Metaxin1/3.
DR   InterPro; IPR033468; Metaxin_GST.
DR   InterPro; IPR019564; Sam37/metaxin_N.
DR   Pfam; PF17171; GST_C_6; 1.
DR   Pfam; PF10568; Tom37; 1.
DR   PIRSF; PIRSF038150; Metaxin; 1.
DR   SUPFAM; SSF47616; SSF47616; 1.
PE   1: Evidence at protein level;
KW   Membrane; Mitochondrion; Mitochondrion outer membrane; Protein transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..312
FT                   /note="Metaxin-1 homolog"
FT                   /id="PRO_0000220993"
FT   TRANSMEM        282..302
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   312 AA;  35320 MW;  C870D8BCE4CB7EB3 CRC64;
     MELHIWPSDF GLPTIDVVSL QFLACSKMCA SPVRVIQSTR PWRSPSGELP MVAQTEGEAK
     PVTDFEKFVD ILKKCGQDVV IDADLTTIEK AQLDAFSCYL HHNLYPAVMH TFWTDELNYN
     TVTQYWYASH LHFPYNLYYL EKRRKKALRL LAGKNDTEIL KEAFMALNTL STKLGDNKFF
     CGNKPTSLDA LVFGYLAPLL RVPLPNDRLQ VQLSACPNLV RFVETVSSIY LPLGEDELKR
     QQANRKMWQS RISKAKADKE AAKTTEEASE SLPEEPPMRD AILFTLGALT LSLVFAIHTG
     LIQVSVEEEI SE
 
 
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